Endoscopic Ultrasound-based Shear Wave Elastography for Detection of Advanced Liver Disease.
J Clin Gastroenterol
; 2024 Apr 23.
Article
en En
| MEDLINE
| ID: mdl-38648501
ABSTRACT
BACKGROUND AND AIMS:
Endoscopic ultrasound shear wave elastography (EUS-SWE) is a novel modality for liver stiffness measurement. The aims of this study are to evaluate the performance and reliability of EUS-SWE for detecting advanced liver disease in a prospective cohort.METHODS:
EUS-SWE measurements were prospectively obtained from patients undergoing EUS between August 2020 and March 2023. Liver stiffness measurements were compared between patients with and without advanced liver disease (ALD), defined as stage ≥3, to determine diagnostic accuracy for advanced fibrosis and portal hypertension. Logistic regression was performed to identify variables that impact the reliability of EUS-SWE readings. Select patients underwent paired magnetic resonance elastography (MRE) for liver fibrosis correlation.RESULTS:
Patients with ALD demonstrated higher liver stiffness compared to healthy controls (left lobe 17.6 vs. 12.7 kPa, P<0.001; median right lobe 24.8 vs. 11.0 kPa, P<0.001). The area under the receiver operator characteristic (AUROC) for the detection of ALD was 0.73 and 0.80 for left and right lobe measurements, respectively. General anesthesia was associated with reliable EUS-SWE liver readings (odds ratio 2.73, 95% CI 1.07-7.39, P=0.040). Left lobe measurements correlated significantly with MRE with an increase of 0.11 kPa (95% CI 0.05-0.17 kPA) for every 1 kPa increase on EUS-SWE. D.CONCLUSIONS:
SWE is a promising technology that can readily be incorporated into standard EUS examinations for the assessment of ALD.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Clin Gastroenterol
/
J. clin. gastroenterol
/
Journal of clinical gastroenterology
Año:
2024
Tipo del documento:
Article