Living Self-Assembly of Monodisperse Micron-Sized Polymer Vesicles.
Angew Chem Int Ed Engl
; 63(27): e202404589, 2024 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-38654509
ABSTRACT
Artificial vesicles are recognized as powerful platforms for a large body of research across the disciplines of chemistry, physics and biology. Despite the great progress, control of the size distribution to make uniform vesicles remains fundamentally difficult due to the highly uncontrollable growth kinetics, especially for micron-sized vesicles. Here we report a template-free living self-assembly method to prepare monodisperse vesicles around 1â
µm from an alternating copolymer. The polymer forms nanodisks (ca. 9â
nm) in N,N-dimethylformamide (DMF), acting as seeds for subsequent growth. By adding water, the nanodisks gradually grow into larger circular bilayer nanosheets, which bend to crowns and continue to grow into uniform micron-sized vesicles. The first-order growth kinetics as well as the small size polydispersity index (<0.1) suggests the living self-assembly characteristics. This work paves a new way in both living self-assembly and monodisperse polymer vesicles.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2024
Tipo del documento:
Article