Plasma pentraxin-3 levels and its role in childhood obesity-Is it anti-inflammatory? A matched group study.
Clin Endocrinol (Oxf)
; 101(1): 13-22, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38691652
ABSTRACT
OBJECTIVE:
Obesity has been associated with chronic low-grade systemic inflammation. This study aimed to investigate the relationship of pentraxin-3 (PTX-3) with anthropometric measurements, dietary content and physical activity level in children.DESIGN:
A matched group study. PATIENTS This study was conducted with 91 children aged 6-17 years, divided into two groups "non-obese group" (Body Mass Index Standard Deviation Score [BMI SDS] <95th percentile) and "obese group" (BMI SDS ≥95th percentile). MEASUREMENTS Plasma PTX-3 levels.RESULTS:
The mean age of 91 children included in the study was 12.34 ± 2.86 years. Plasma PTX-3 levels were significantly higher in obese children (p = .028). No significant correlation was found between BMI SDS and plasma PTX-3 values, but a weak positive correlation was found when physical activity level was controlled (r = .176, p = .049). In addition, it was found that fat mass was a partial mediator of plasma PTX-3 level, and an increase in the amount of subcutaneous adipose tissue negatively affected plasma PTX-3 level. Plasma PTX-3 level showed a weak positive correlation (r = .223, p = .017) with physical activity score and dietary polyunsaturated fatty acid intake, while a weak negative correlation with neutrophil-to-lymphocyte ratio. One unit increase in physical activity score or polyunsaturated fatty acid level caused 0.730 and 2.061 unit increases in plasma PTX-3 level, respectively; while one unit increase in dietary fat intake caused 0.413-unit decrease.CONCLUSION:
There was an indirect relationship between the amount of subcutaneous adipose tissue and PTX-3 level. The results of our study suggested that plasma PTX-3 was associated with lower levels of inflammation in children.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteína C-Reactiva
/
Componente Amiloide P Sérico
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Obesidad Infantil
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía