From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish.
Trends Genet
; 40(1): 24-38, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38707509
ABSTRACT
How genotype determines phenotype is a well-explored question, but genotype-environment interactions and their heritable impact on phenotype over the course of evolution are not as thoroughly investigated. The fish Astyanax mexicanus, consisting of surface and cave ecotypes, is an ideal emerging model to study the genetic basis of adaptation to new environments. This model has permitted quantitative trait locus mapping and whole-genome comparisons to identify the genetic bases of traits such as albinism and insulin resistance and has helped to better understand fundamental evolutionary mechanisms. In this review, we summarize recent advances in A. mexicanus genetics and discuss their broader impact on the fields of adaptation and evolutionary genetics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sitios de Carácter Cuantitativo
/
Characidae
/
Cuevas
Límite:
Animals
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos