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Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors.
Postovalova, Alisa S; Tishchenko, Yulia A; Istomina, Maria S; Karpov, Timofey E; Shipilovskikh, Sergei A; Akhmetova, Daria; Rogova, Anna; Gavrilova, Nina V; Timin, Alexander S.
Afiliación
  • Postovalova AS; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia; ITMO University, Kronverksky Prospekt 49, bldg. A, St. Petersburg 191002, Russia.
  • Tishchenko YA; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia; St. Petersburg Academic University, St. Petersburg, Russia.
  • Istomina MS; Federal State Budgetary Institution "V.A. Almazov National Medical Research Center" of the Ministry of Health of the Russian Federation, St. Petersburg, Russia; St. Petersburg State Electrotechnical University "LETI" named after V.I. Ulyanov (Lenin), St. Petersburg, Russia.
  • Karpov TE; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia.
  • Shipilovskikh SA; ITMO University, Kronverksky Prospekt 49, bldg. A, St. Petersburg 191002, Russia.
  • Akhmetova D; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia; ITMO University, Kronverksky Prospekt 49, bldg. A, St. Petersburg 191002, Russia.
  • Rogova A; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia.
  • Gavrilova NV; Labratory of Intracellular Signaling and Transport, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg 197376, Russia; Research Complex "Immunobiotechnology and Gene Therapy", Peter the Great St. Petersburg Polytechnic University, Saint-Petersb
  • Timin AS; Laboratory of Nano- and Microencapsulation of Biologically Active Substances, Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg 195251, Russia. Electronic address: timin_as@spbstu.ru.
Nanomedicine ; 59: 102753, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38734039
ABSTRACT
In this study, we have considered four types of nanoparticles (NPs) polylactic acid (PLA), gold (Au), calcium carbonate (CaCO3), and silica (SiO2) with similar sizes (TEM 50-110 nm and DLS 110-140 nm) to examine their passive accumulation in three different tumors colon (CT26), melanoma (B16-F10), and breast (4T1) cancers. Our results demonstrate that each tumor model showed a different accumulation of NPs, in the following order CT26 > B16-F10 > 4T1. The Au and PLA NPs were evidently characterized by a higher delivery efficiency in case of CT26 tumors compared to CaCO3 and SiO2 NPs. The Au NPs demonstrated the highest accumulation in B16-F10 cells compared to other NPs. These results were verified using SPECT, ex vivo fluorescence bioimaging, direct radiometry and histological analysis. Thus, this work contributes to new knowledge in passive tumor targeting of NPs and can be used for the development of new strategies for delivery of bioactive compounds.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas / Oro Límite: Animals / Female / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Nanopartículas / Oro Límite: Animals / Female / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Rusia