METTL1-mediated tRNA m<sup>7</sup>G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade.

Du, Dan; Zhou, Mingxia; Ju, Chenxi; Yin, Jie; Wang, Chang; Xu, Xinyu; Yang, Yunqing; Li, Yun; Cui, Le; Wang, Zhengyang; Lei, Yuqing; Li, Hongle; He, Fucheng; He, Jing

METTL1-mediated tRNA m⁷G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade.

Du, Dan; Zhou, Mingxia; Ju, Chenxi; Yin, Jie; Wang, Chang; Xu, Xinyu; Yang, Yunqing; Li, Yun; Cui, Le; Wang, Zhengyang; Lei, Yuqing; Li, Hongle; He, Fucheng; He, Jing.

Afiliación

Du D; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhou M; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Ju C; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yin J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wang C; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Xu X; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yang Y; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Li Y; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Cui L; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wang Z; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Lei Y; Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China.
Li H; Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. llhl73@163.com.
He F; Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hefucheng@zzu.edu.cn.
He J; Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hejing921@zzu.edu.cn.

J Exp Clin Cancer Res ; 43(1): 154, 2024 May 31.

Article en En | MEDLINE | ID: mdl-38822363

Asunto(s)

Neoplasias de la Mama; Metiltransferasas; ARN de Transferencia; Humanos; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Femenino; Ratones; Animales; Metiltransferasas/metabolismo; Metiltransferasas/genética; ARN de Transferencia/genética; ARN de Transferencia/metabolismo; Metilación; Línea Celular Tumoral; Proliferación Celular; Carcinogénesis/genética; Puntos de Control del Ciclo Celular; Biosíntesis de Proteínas; Ensayos Antitumor por Modelo de Xenoinjerto; Ratones Desnudos

Palabras clave

Breast cancer; CDK4/6; Cell cycle; GADD45A; METTL1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / ARN de Transferencia / Metiltransferasas Límite: Animals / Female / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2024 Tipo del documento: Article País de afiliación: China

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