Can placebo-controlled phase 2 disease-modifying therapy trials in MS still be justified?

Giovannoni, Gavin; Hawkes, Christopher H; Lechner-Scott, Jeannette; Levy, Michael; Yeh, E Ann; Pepper, George; Schmierer, Klaus

Giovannoni, Gavin; Hawkes, Christopher H; Lechner-Scott, Jeannette; Levy, Michael; Yeh, E Ann; Pepper, George; Schmierer, Klaus.

Afiliación

Giovannoni G; The Blizard Institute, Centre for Neuroscience, Surgery & Trauma, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; Clinical Board Medicine (Neuroscience), The Royal London Hospital, Barts Health NHS Trust, London, UK. Electronic address: g.giovannoni@qmul.ac.uk.
Hawkes CH; The Blizard Institute, Centre for Neuroscience, Surgery & Trauma, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lechner-Scott J; The University of Newcastle, Australia.
Levy M; Massachusetts General Hospital and Harvard Medical School, Massachusetts, USA.
Yeh EA; Department of Paediatrics, Dalla Lana School of Public Health, University of Toronto.
Pepper G; Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom.
Schmierer K; The Blizard Institute, Centre for Neuroscience, Surgery & Trauma, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; Clinical Board Medicine (Neuroscience), The Royal London Hospital, Barts Health NHS Trust, London, UK.

Mult Scler Relat Disord ; 87: 105698, 2024 Jul.

Article en En | MEDLINE | ID: mdl-38850685

Asunto(s)

Ensayos Clínicos Fase II como Asunto; Esclerosis Múltiple; Humanos; Esclerosis Múltiple/tratamiento farmacológico; Esclerosis Múltiple/terapia; Factores Inmunológicos/uso terapéutico

Palabras clave

Ethics; Phase 2 clinical trials; Placebo-controlled

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ensayos Clínicos Fase II como Asunto / Esclerosis Múltiple Límite: Humans Idioma: En Revista: Mult Scler Relat Disord / Multiple sclerosis and related disorders / Multiple sclerosis and related disorders (Online) Año: 2024 Tipo del documento: Article

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