Oral cavity squamous cell carcinomas in zoo-managed Goeldi's monkeys (Callimico goeldii).
J Med Primatol
; 53(3): e12717, 2024 Jun.
Article
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| MEDLINE
| ID: mdl-38853391
ABSTRACT
BACKGROUND:
Oral cavity squamous cell carcinomas (OCSCCs) are relatively common in multiple non-human primate species but are poorly documented in Goeldi's monkeys.METHODS:
Four Goeldi's monkeys with OCSCC, from three zoological collections, underwent necropsy with cytology, histopathology, immunohistochemistry, and pan-herpesvirus PCR analysis.RESULTS:
All animals were euthanised and exhibited poor-to-emaciated body condition. Three OCSCCs arose from the maxillary oral mucosa and a single OCSCC was primarily mandibular, with bone invasion evident in three cases. Histologically, one OCSCC in situ was diagnosed, whilst the rest were typically invasive OCSCCs. Neoplastic cells were immunopositive for pancytokeratin and E-cadherin. All examined cases were negative for regional lymph node (RLN) and/or distant metastases, cyclooxygenase-2 (COX-2) immunoexpression, and panherpesvirus PCR expression.CONCLUSIONS:
OCSCCs in Goeldi's monkeys may be deeply invasive, but not readily metastatic. No herpesvirus-association or COX-2 expression was evident; the latter suggesting that NSAIDs are unlikely to be a viable chemotherapeutic treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Animales de Zoológico
/
Enfermedades de los Monos
Límite:
Animals
Idioma:
En
Revista:
J Med Primatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido