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Rethinking the role of trazodone in the different depressive dimensions.
Berardelli, Isabella; Amerio, Andrea; Bartoli, Francesco; Cuomo, Alessandro; Deste, Giacomo; Orsolini, Laura; Sampogna, Gaia; Pompili, Maurizio.
Afiliación
  • Berardelli I; Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Centre, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Amerio A; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy.
  • Bartoli F; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Cuomo A; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
  • Deste G; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
  • Orsolini L; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Sampogna G; Department of Mental Health and Addiction Services, ASST Valcamonica, Esine, Italy.
  • Pompili M; Unit of Clinical Psychiatry, Department of Neurosciences/DIMSC, Polytechnic University of Marche, Ancona, Italy.
Expert Rev Neurother ; 24(7): 619-632, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38881379
ABSTRACT

INTRODUCTION:

The efficacy of trazodone for several psychopathologic dimensions of depression has been shown in the literature. Trazodone has been widely used in some clinical contexts (e.g. for insomnia and depression in the elderly). However, the role of trazodone in several aspects of depression is not well known. AREA COVERED Eight experts from academic and medical centers across Italy met to identify the difficulties and barriers faced in daily clinical practice in the assessment and management of major depressive disorder and how the use of trazodone could address some unmet needs. The objective of the expert meetings and the present document was to increase knowledge of particular areas of treatment with trazodone. EXPERT OPINION Evidence of the role of trazodone in patients affected by major depressive disorder with anxiety symptoms, insomnia, agitation, cognitive deficits, alcohol use disorders, physical comorbidities, and suicide risk has been identified, showing the effectiveness of trazodone in different presentations of major depressive disorder. The main characteristics of patients with depression for whom trazodone seems to be most effective have been identified, providing clinicians with information on possible uses of this drug in such population of patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trazodona / Antidepresivos de Segunda Generación / Trastorno Depresivo Mayor Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Expert Rev Neurother Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trazodona / Antidepresivos de Segunda Generación / Trastorno Depresivo Mayor Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Expert Rev Neurother Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Italia