In Vitro Human Endometrial Cells and In Vivo Rat Model Studies Suggest That Ulipristal Acetate Impacts Endometrial Compatibility for Embryo Implantation.
Arch Med Res
; 55(8): 103026, 2024 Jun 19.
Article
en En
| MEDLINE
| ID: mdl-38897915
ABSTRACT
BACKGROUND:
Ulipristal acetate (UPA) and levonorgestrel are used as emergency hormonal contraceptives. Although both are highly effective in preventing pregnancy, UPA shows efficacy even when taken up to 120 h after unprotected sexual intercourse.AIMS:
To investigate whether the mechanism of UPA's contraceptive action involves post-fertilization effects.METHODS:
In vitro and in vivo studies using cultured human endometrial cells and a pre-clinical rat model.RESULTS:
Endometrial cells treated with UPA showed changes in the expression of receptivity gene markers and a significant decrease in trophoblast spheroids attached to the cultured cells. In addition, administration of UPA to female unmated rats decreased the expression of implantation-related genes in the endometrium and inhibited the number of implantation sites in the mated group compared to the non-treated group.CONCLUSIONS:
These results support that UPA as an emergency contraceptive might have post-fertilization effects that may affect embryo implantation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Arch Med Res
Asunto de la revista:
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
México