Comparison of the effects of norepinephrine and phenylephrine on shivering and hypothermia in patients undergoing caesarean section under spinal anaesthesia at a tertiary hospital in Chinaï¼a randomised, double-blind, controlled trial protocol.
BMJ Open
; 14(7): e083202, 2024 Jul 11.
Article
en En
| MEDLINE
| ID: mdl-38991676
ABSTRACT
INTRODUCTION:
Peripheral vasodilation causes a redistribution of body temperature from the core to the periphery, resulting in shivering and hypothermia. These are normal pathological and physiological processes during spinal anaesthesia. Two drugs, norepinephrine and phenylephrine, have peripheral vasoconstrictive effects. It is unclear the effects of norepinephrine and phenylephrine on shivering and hypothermia in patients undergoing caesarean section under spinal anaesthesia. METHODSANALYSIS:
240 eligible parturients will be recruited for this randomised, double-blind, controlled trial and randomly assigned to either the norepinephrine or phenylephrine groups. The primary outcome will be the incidence of shivering while secondary outcomes will include the severity of shivering, rectal temperature, incidence of hypothermia and umbilical artery blood pH value. ETHICS AND DISSEMINATION The Institutional Ethics Committee of The Second People's Hospital of Hefei approved the trial protocol (ID 2023-093). The results will be published in a compliant journal. The original data will be released in December 2029 on the ResMan original data-sharing platform of the China Clinical Trial Registry (http//www.medresman.org.cn). TRIAL REGISTRATION NUMBER ChiCTR2300077164.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenilefrina
/
Tiritona
/
Norepinefrina
/
Cesárea
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Centros de Atención Terciaria
/
Hipotermia
/
Anestesia Raquidea
Límite:
Adult
/
Female
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Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
BMJ Open
Año:
2024
Tipo del documento:
Article
País de afiliación:
China