Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice.
Neurosci Lett
; 836: 137897, 2024 Jul 27.
Article
en En
| MEDLINE
| ID: mdl-39004114
ABSTRACT
The efficacy of vitamin C in age-related hearing loss, i.e., presbycusis, remains debatable. On a separate note, inflammation induced by the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is involved in the progression of presbycusis. In this study, we investigated the effect of vitamin C on male C57BL/6 mice's presbycusis and NLRP3 inflammasome. The results showed that vitamin C treatment improved hearing, reduced the production of inflammatory factors, inhibited NLRP3 inflammasome activation, and decreased cytosolic mitochondrial DNA (mtDNA) in the C57BL/6 mouse cochlea, inferior colliculus, and auditory cortex. According to this study, vitamin C protects auditory function in male C57BL/6 presbycusis mice through reducing mtDNA release, inhibiting the NLRP3 inflammasome activation in the auditory pathway. Our study provides a theoretical basis for applying vitamin C to treat presbycusis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Presbiacusia
/
Ácido Ascórbico
/
ADN Mitocondrial
/
Inflamasomas
/
Proteína con Dominio Pirina 3 de la Familia NLR
/
Ratones Endogámicos C57BL
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2024
Tipo del documento:
Article
País de afiliación:
China