DR-70 (fibrinogen-fibrin degradation products) as a prognostic biomarker in dogs with neoplasms.
Vet Q
; 44(1): 1-10, 2024 Dec.
Article
en En
| MEDLINE
| ID: mdl-39028259
ABSTRACT
Fibrinogen-fibrin degradation products (DR-70) are derived from tumor cells or metastases. Our previous study reported the diagnostic values in dogs with tumors, but no research has yet to be conducted to establish DR-70 as a prognostic marker. Herein, we investigated changes in DR-70 concentrations and disease courses in dogs with tumors. Overall survival time (OST) analysis was performed in 195 dogs with tumors, stratified with a recommended cut-off (1.514 µg/mL). Continual DR-70 measurements were performed during the medical interventions of 27 dogs with neoplasms. Clinical conditions and medical records were retrospectively reviewed. According to a cut-off value, dogs with plasma DR-70 concentrations above 1.514 µg/mL had shorter survival rates than those with concentrations below this threshold. In cases with complete or partial remission in response to treatment, the DR-70 concentration was decreased compared with that at the first visit, whereas it was increased in patients with disease progression. Our study suggested that changes in DR-70 concentration can be used as a prognostic biomarker for canine neoplasms. Furthermore, increased plasma DR-70 levels might be associated with shorter survival, and DR-70 concentrations may reflect responses to medical intervention.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Productos de Degradación de Fibrina-Fibrinógeno
/
Biomarcadores de Tumor
/
Enfermedades de los Perros
/
Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Vet Q
Año:
2024
Tipo del documento:
Article
País de afiliación:
Taiwán