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Protective role of macrophages from maternal-fetal interface in unvaccinated coronavirus disease 2019 pregnant women.
Gay, Laetitia; Madariaga Zarza, Sandra; Abou Atmeh, Perla; Rouvière, Marie-Sarah; Andrieu, Jonatane; Richaud, Manon; Boumaza, Asma; Miquel, Laura; Diallo, Aïssatou Bailo; Bechah, Yassina; Otmani Idrissi, Myriem; La Scola, Bernard; Olive, Daniel; Resseguier, Noémie; Bretelle, Florence; Mezouar, Soraya; Mege, Jean-Louis.
Afiliación
  • Gay L; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Madariaga Zarza S; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Abou Atmeh P; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Rouvière MS; Institut Paoli-Calmettes, UM105, Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
  • Andrieu J; Centre National de la Recherche Scientifique, Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé, Aix-Marseille University, Marseille, France.
  • Richaud M; Institut Paoli-Calmettes, UM105, Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
  • Boumaza A; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Miquel L; Department of Gynaecology-Obstetrics, La Conception Hospital, Marseille, France.
  • Diallo AB; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Bechah Y; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Otmani Idrissi M; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • La Scola B; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Olive D; Institut Paoli-Calmettes, UM105, Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
  • Resseguier N; Assistance Publique-Hôpitaux de Marseille, La Timone Hospital, Department of Epidemiology and Health Economics, Clinical Research Unit, Direction of Health Research, Aix Marseille University, Marseille, France.
  • Bretelle F; Institut Recherche Développement, Assistance Publique-Hôpitaux de Marseille, Microbe, Evolution, Phylogeny and Infection, Aix-Marseille University, Marseille, France.
  • Mezouar S; Department of Gynaecology-Obstetrics, La Conception Hospital, Marseille, France.
  • Mege JL; Centre National de la Recherche Scientifique, Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé, Aix-Marseille University, Marseille, France.
J Med Virol ; 96(7): e29819, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39030992
ABSTRACT
Pregnant women represent a high-risk population for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. The presence of SARS-CoV-2 has been reported in placenta from infected pregnant women, but whether the virus influences placenta immune response remains unclear. We investigated the properties of maternal-fetal interface macrophages (MFMs) in a cohort of unvaccinated women who contracted coronavirus disease 2019 (COVID-19) during their pregnancy. We reported an infiltration of CD163+ macrophages in placenta from COVID-19 women 19 whereas lymphoid compartment was not affected. Isolated MFMs exhibited nonpolarized activated signature (NOS2, IDO1, IFNG, TNF, TGFB) mainly in women infected during the second trimester of pregnancy. COVID-19 during pregnancy primed MFM to produce type I and III interferon response to SARS-CoV-2 (Wuhan and δ strains), that were unable to elicit this in MFMs from healthy pregnant women. COVID-19 also primed SARS-CoV-2 internalization by MFM in an angiotensin-converting enzyme 2-dependent manner. Activation and recall responses of MFMs were influenced by fetal sex. Collectively, these findings support a role for MFMs in the local immune response to SARS-CoV-2 infection, provide a basis for protective placental immunity in COVID-19, and highlight the interest of vaccination in pregnant women.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Complicaciones Infecciosas del Embarazo / SARS-CoV-2 / COVID-19 / Macrófagos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Med Virol Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Complicaciones Infecciosas del Embarazo / SARS-CoV-2 / COVID-19 / Macrófagos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Med Virol Año: 2024 Tipo del documento: Article País de afiliación: Francia