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Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
Kloske, Courtney M; Belloy, Michael E; Blue, Elizabeth E; Bowman, Gregory R; Carrillo, Maria C; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A; Paolo, Gilbert Di; Garretti, Francesca; Gate, David; Golden, Lesley R; Heinecke, Jay W; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A; Kanekiyo, Takahisa; Karch, Celeste M; Khvorova, Anastasia; Koppes-den Hertog, Sascha J; Lamb, Bruce T; Lawler, Paige E; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M; Miller, Justin J; Morganti, Josh M; Narayan, Priyanka S; Naslavsky, Michel S; Oosthoek, Marlies; Ramachandran, Kapil V; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N M; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J; Soranno, Andrea; Strickland, Michael R; Tcw, Julia; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A.
Afiliación
  • Kloske CM; Alzheimer's Association, Chicago, Illinois, USA.
  • Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, Palo Alto, California, USA.
  • Blue EE; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Bowman GR; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.
  • Carrillo MC; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Chen X; Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA.
  • Chiba-Falek O; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Davis AA; Alzheimer's Association, Chicago, Illinois, USA.
  • Paolo GD; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Garretti F; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.
  • Gate D; Department of Neurology Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, Missouri, USA.
  • Golden LR; Denali Therapeutics Inc., San Francisco, California, USA.
  • Heinecke JW; Ronald M. Loeb Center for Alzheimer's Disease, New York, New York, USA.
  • Herz J; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Huang Y; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Iadecola C; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
  • Johnson LA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
  • Kanekiyo T; Department of Medicine, University of Washington, UV Medicine, Seattle, Washington, USA.
  • Karch CM; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Khvorova A; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.
  • Koppes-den Hertog SJ; Department of Neurology, University of California, San Francisco, California, USA.
  • Lamb BT; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
  • Lawler PE; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
  • Guen YL; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
  • Litvinchuk A; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
  • Liu CC; Department of Psychiatry, Washington University in St Louis, St. Louis, Missouri, USA.
  • Mahinrad S; RNA Therapeutic Institute, UMass Chan Medical School, Worcester, Massachusetts, USA.
  • Marcora E; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.
  • Marino C; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA.
  • Michaelson DM; Stark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Miller JJ; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.
  • Morganti JM; The Tracy Family SILQ Center, Washington University School of Medicine, Indianapolis, Indiana, USA.
  • Narayan PS; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
  • Naslavsky MS; Institut du Cerveau-Paris Brain Institute-ICM, Paris, France.
  • Oosthoek M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Ramachandran KV; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
  • Ramakrishnan A; Alzheimer's Association, Chicago, Illinois, USA.
  • Raulin AC; Department of Genetics and Genomic Sciences, Nash Family Department of Neuroscience, Icahn Genomics Institute; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Robert A; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA.
  • Saleh RNM; Sagol School of Neuroscience Tel Aviv University, Tel Aviv, Israel.
  • Sexton C; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Shah N; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Shue F; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
  • Sible IJ; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
  • Soranno A; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, Center for Alzheimer's and Related Dementias (CARD), National Institutes of Health, Maryland, USA.
  • Strickland MR; Human Genome and Stem-cell Research Center, Biosciences Institute, University of São Paulo, Rua do Matao, São Paulo, Brazil.
  • Tcw J; Hospital Israelita Albert Einstein, Avenida Albert Einstein, São Paulo, Brazil.
  • Thierry M; Neurochemistry Laboratory, Department of Laboratory Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
  • Tsai LH; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
  • Tuckey RA; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Alzheimers Dement ; 2024 Jul 19.
Article en En | MEDLINE | ID: mdl-39031528
ABSTRACT

INTRODUCTION:

The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.

METHODS:

In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.

RESULTS:

This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.

DISCUSSION:

Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine. HIGHLIGHTS APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements APOE conference encouraged discussions and collaborations on understanding the role of APOE.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos