Your browser doesn't support javascript.
loading
Three New Polyprenylated Benzophenone Derivatives Isolated from Clusia burle-marxii.
C Silva, Maria do Carmo; V Carvalho, Fernanda; G Ferreira, Antonio; Venâncio, Tiago; G F da Silva, Maria Fátima; A Silva, Victor Diogenes; L Costa, Silvia; G Ferraz, Caline G; Ribeiro, Paulo Roberto.
Afiliación
  • C Silva MDC; Federal University of Bahia, Quimica Orgânica, Rua Barão de Jeremoabo, Salvador, BRAZIL.
  • V Carvalho F; Federal University of Bahia, Quimica Orgânica, Rua Barão de Jeremoabo, Salvador, BRAZIL.
  • G Ferreira A; Federal University of Sao Carlos, Química, Rodovia Washington Luis, São Carlos, BRAZIL.
  • Venâncio T; Federal University of Sao Carlos, Organic Chemistry, Rodovia Washington Luis, São Carlos, BRAZIL.
  • G F da Silva MF; Federal University of Sao Carlos, Química, Rodovia Washington Luis, São Carlos, BRAZIL.
  • A Silva VD; Federal University of Bahia, Bioquimica, Rua Barão de Jeremoabo, Salvador, BRAZIL.
  • L Costa S; Federal University of Bahia, Bioquimica, Rua Barão de Jeremoabo, Salvador, BRAZIL.
  • G Ferraz CG; Federal University of Bahia, Quimica Orgânica, Rua Barão de Jeremoabo, Salvador, BRAZIL.
  • Ribeiro PR; Universidade Federal da Bahia, Química Orgânica, Rua Professor Sabino silva 356 Ed Saint Paul, ap 502, 40155250, Salvador, BRAZIL.
Chem Biodivers ; : e202401450, 2024 Jul 21.
Article en En | MEDLINE | ID: mdl-39034294
ABSTRACT
Three new polyprenylated benzophenone derivatives named burlemarxione G-I (1-3) were isolated from C. burle-marxii trunks (compound 1) and leaves (compounds 2 and 3), along with the known compound burlemarxione F. Burlemarxione G (1) was isolated after methylation with diazomethane and it is the keto-enol tautomeric pair of burlemarxione F. Burlemarxione H (2) derives from burlemarxiones F and G, but it has additional rings due to cyclization of the prenyl group attached to C-5 that establishes new single bonds between C-1 and C-23, as well as, between C-24 and C-29. Burlemarxione I (3) has two additional cyclizations the first encompasses the cyclization of the former isopentenyl group into an 11,11-dimethyl-six-membered ring, whereas the second produces additional rings due to the cyclization of the prenyl group attached to C-5 that establishes new single bonds between C-1 and C-23, as well as, between C-24 and C-29. All three compounds showed moderate anti-glioma activity. These results show that C. burle-marxii is an important source of sophisticated polyprenylated benzophenone derivatives.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil