Binding of transferrin-iron by adriamycin at acidic pH.
FEBS Lett
; 196(2): 321-4, 1986 Feb 17.
Article
en En
| MEDLINE
| ID: mdl-3949004
ABSTRACT
It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1. The kinetics of iron transfer to free adriamycin and to adriamycin covalently attached to the transferrin has been determined. The results show that adriamycin, if introduced into intracellular acidic compartments, could function as acceptor for transferrin-iron.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transferrina
/
Doxorrubicina
/
Hierro
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1986
Tipo del documento:
Article