Synergistic effect of AMP and fructose 2,6-bisphosphate on the protection of fructose 1,6-bisphosphatase against inactivation by trypsin.
Experientia
; 39(11): 1305-7, 1983 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-6315478
ABSTRACT
The rate of inactivation of chicken liver fructose 1,6-bisphosphatase by trypsin is reduced if the digestive reaction is conducted in the presence of AMP or fructose 2,6-bisphosphate. The effects of these 2 compounds are synergistic. Although fructose 1,6-bisphosphate does not protect the enzyme against tryptic inactivation, it can enhance the effect of AMP. Selective modification of the AMP allosteric site of fructose 1,6-bisphosphatase with pyridoxal-P and NaBH4 renders the enzyme more resistant to tryptic inactivation, but the modified enzyme is no longer responsive to the protective effect of AMP.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tripsina
/
Adenosina Monofosfato
/
Fructosa-Bifosfatasa
/
Fructosadifosfatos
/
Hexosadifosfatos
Límite:
Animals
Idioma:
En
Revista:
Experientia
Año:
1983
Tipo del documento:
Article