Thyroid xanthine oxidase and its role in thyroid iodine metabolism in the rat: difference between effects of allopurinol and tungstate.
J Endocrinol
; 95(1): 117-24, 1982 Oct.
Article
en En
| MEDLINE
| ID: mdl-6957531
ABSTRACT
The role of xanthine oxidase in thyroid function was studied in the rat in vivo by different approaches. Allopurinol, an inhibitor of xanthine oxidase, was administered by mixing it with a powdered diet (16 mg/100 g body wt per day for 10 days). This treatment significantly reduced the total uptake of iodide and inhibited the organification of iodide in the rat thyroid gland. Thyroid xanthine oxidase and dehydrogenase were almost completely inactivated by tungstate, which was given to rats (100 p.p.m./animal per day in drinking water for 10 days) maintained on a purified diet containing low levels of molybdenum. Under these conditions, no inhibitory effect was observed on synthesis of thyroid hormones. It therefore seemed reasonable to assume that the suppressive effect of allopurinol on the biosynthesis of thyroid hormones is not mediated by xanthine oxidase.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
/
Xantina Oxidasa
/
Compuestos de Tungsteno
/
Yodo
Límite:
Animals
Idioma:
En
Revista:
J Endocrinol
Año:
1982
Tipo del documento:
Article