Susceptibility to penicillins and cephalosporins in beta-lactamase producing strains of E. coli and relative amount of beta-lactamase produced from these strains.
Scand J Infect Dis Suppl
; suppl 25: 23-9, 1980.
Article
en En
| MEDLINE
| ID: mdl-7010537
ABSTRACT
The genetic and physiological mechanisms for affecting the amount of chromosomally mediated beta-lactamase of Escherichia coli K 12 was reviewed. The presence of clinical E. coli isolates with elevated beta-lactamase production was assessed. Among cephalothin resistant isolates from patients with urinary tract infections, six E. coli strains were found to produce elevated amounts of a beta-lactamase indistinguishable from that coded by the ampC gene of E. coli K 12. The resistance levels displayed by these isolates towards a number of beta-lactams was very high as compared to E. coli strains being wild type for chromosomal beta-lactamase production. Cefuroxime and to lesser extent cefamandole were stable to hydrolysis by E. coli chromosomal beta-lactamase but acted as inhibitors of the enzyme. Nevertheless increased beta-lactamase production mediated an increased resistance towards these drugs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
/
Escherichia coli
Idioma:
En
Revista:
Scand J Infect Dis Suppl
Año:
1980
Tipo del documento:
Article