Comparison of serum bilirubin levels in humans and two monogastric animal species after a single administration of sulfisoxazole.
J Pharm Sci
; 71(1): 70-3, 1982 Jan.
Article
en En
| MEDLINE
| ID: mdl-7057385
ABSTRACT
Administration of sulfonamides during periods of hepatobiliary failure or hepatic immaturity increases the toxic potential of unconjugated or indirect bilirubin. A small but statistically significant increase of indirect, or unconjugated bilirubin was noted in dogs after oral administration of sulfisoxazole (100 mg/kg). A similar increase was not observed in swine after oral or intravenous administration of sulfisoxazole (100 mg/kg) or in humans (approximately 28 mg/kg) after oral administration or in dogs (100 mg/kg) after intravenous administration. Total and conjugated bilirubin showed small but statistically significant increases and were significantly correlated in dogs after oral and intravenous administration of sulfisoxazole (100 mg/kg) and in swine after oral administration of sulfisoxazole (100 mg/kg). There was a significant negative correlation between conjugated and indirect bilirubin, while total bilirubin increased in dogs after oral and intravenous administration of sulfisoxazole. These data illustrate a difference in species and administration route when attempting to assess the potential toxicity of bilirubin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulfisoxazol
/
Bilirrubina
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Pharm Sci
Año:
1982
Tipo del documento:
Article