The action of cobra venom phospholipase A2 isoenzymes towards intact human erythrocytes.
Biochim Biophys Acta
; 600(3): 1012-7, 1980 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-7407131
ABSTRACT
1. Cobra venom phospholipase A2 from three different sources has been fractionated into different isoenzymes by DEAE ion-exchange chromatography. 2. Treatment of intact human erythrocytes with the various isoenzymes revealed significant differences in the degree of phospatidylcholine hydrolysis in those cells. 3. It is argued that the plateaus observed in dose-response curves for such treatments may be caused by an increase in lateral surface presure within the outer half of the membrane due to the production of free fatty acids and lyso-compounds.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Fosfolipasas
/
Fosfolipasas A
/
Venenos Elapídicos
/
Membrana Eritrocítica
/
Eritrocitos
/
Lípidos de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1980
Tipo del documento:
Article