Effects of vasectomy on the epididymis.
Microsc Res Tech
; 30(1): 82-100, 1995 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-7711322
ABSTRACT
PIP: The changes in the epididymal epithelium, luminal contents, inflammation in the epididymal interstitial tissue, and gross epididymal alterations after vasectomy are described. Studies of vasectomy and its reversal by vasovasostomy in the rat as a model system conducted over the decade prior to 1993 were reviewed. Common principles can be discerned in the response of the epididymis to vasectomy, despite species differences (rat, rabbit, guinea pig, and hamster). Increases in the size and number of lysosomes are the most frequent changes in the epididymal epithelium. The presence or absence of additional alterations such as changes in the height of the epithelium may be related to variations in distensibility of the vas deferens and epididymis. In the guinea pig and hamster the intratubular hydrostatic pressure in the seminiferous tubule was significantly lower (p 0.001) than in the caput epididymis. Direct measurements by micropuncture of epididymal and seminiferous tubule hydrostatic pressure indicate that, contrary to dogma, increased pressure in the distal epididymis after vasectomy is not generally transmitted to the seminiferous tubules. The epididymal interstitium shows microscopic changes indicative of chronic inflammation, with infiltration of macrophages, lymphocytes, and plasma cells, and rats with these lesions have higher antisperm antibody levels than animals lacking epididymal changes. Cyst-like spermatic granulomas occur in virtually all species where the epididymis or vas deferens ruptures with escape of spermatozoa. The sites and timing of granuloma formation may depend on the mechanical properties of the tract in different species, and they are probably important in the immune response to vasectomy. Postvasectomy sera in Lewis rats recognize a consensus repertoire of dominant autoantigens that closely resembles the antigens bound by sera from rats immunized with isologous spermatozoa. There are multiple routes for disposal of the sperm that continue to be produced after vasectomy.
Palabras clave
Antibodies; Biology; Contraception; Contraceptive Agents; Diseases; Epididymis; Family Planning; Genitalia; Genitalia, Male; Granulomas; Immunity; Immunologic Factors; Literature Review; Male Sterilization; Physiology; Signs And Symptoms; Sperm Immobilizing Agents; Spermicidal Contraceptive Agents; Sterilization, Sexual; Testis; Urogenital System; Vas Deferens; Vasectomy--side effects
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasectomía
/
Epidídimo
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Microsc Res Tech
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
1995
Tipo del documento:
Article