Stressful life events, genetic liability, and onset of an episode of major depression in women.
Am J Psychiatry
; 152(6): 833-42, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7755111
ABSTRACT
OBJECTIVE:
This study was undertaken to clarify how genetic liability and stressful life events interact in the etiology of major depression.METHOD:
Information about stressful life events and onset of major depressive episodes in the past year was collected in a population-based sample of female-female twin pairs including 2,164 individuals, 53,215 person-months of observation, and 492 onsets of depression.RESULTS:
Nine "personal" and three aggregate "network" stressful events significantly predicted onset of major depression in the month of occurrence, four of which predicted onset with an odds ratio of > 10 and were termed "severe" death of a close relative, assault, serious marital problems, and divorce/breakup. Genetic liability also had a significant impact on risk of onset of depression. For severe stressful events, as well as for 10 of the 12 individual stressful events, the best-fitting model for the joint effect of stressful events and genetic liability on onset of major depression suggested genetic control of sensitivity to the depression-inducing effects of stressful life events. In individuals at lowest genetic risk (monozygotic twin, co-twin unaffected), the probability of onset of major depression per month was predicted to be 0.5% and 6.2%, respectively, for those unexposed and exposed to a severe event. In those at highest genetic risk (monozygotic twin, co-twin affected), these probabilities were 1.1% and 14.6%, respectively. Linear regression analysis indicated significant Genotype by Environment interaction in the prediction of onset of major depression.CONCLUSIONS:
Genetic factors influence the risk of onset of major depression in part by altering the sensitivity of individuals to the depression-inducing effect of stressful life events.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo
/
Enfermedades en Gemelos
/
Acontecimientos que Cambian la Vida
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Am J Psychiatry
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos