Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages.
Tuber Lung Dis
; 75(4): 283-5, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-7949074
ABSTRACT
SETTING:
Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii.OBJECTIVE:
To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium.DESIGN:
The activity of clarithromycin (4 micrograms/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 micrograms/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 micrograms/ml.RESULTS:
While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P < 0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin.CONCLUSION:
Chloroquine should not improve clarithromycin treatment against M. avium infection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cloroquina
/
Claritromicina
/
Macrófagos
/
Mycobacterium avium
Límite:
Humans
Idioma:
En
Revista:
Tuber Lung Dis
Año:
1994
Tipo del documento:
Article