Transplacental transmission of Wuchereria bancrofti in Haitian women.
J Parasitol
; 79(1): 62-6, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8437059
ABSTRACT
To document the occurrence of transplacental transmission of microfilariae and to determine how frequently it occurred, umbilical cord blood samples and placental tissues were collected from 22 microfilaria-positive women in an area with endemic Wuchereria bancrofti. Microfilaria (mf) counts in the women ranged from 1 to 3,820 mf/ml. Microfilariae were detected in 2 placenta samples and a single cord blood sample. The positive cord blood sample and 1 of the positive placenta samples came from the same woman; no microfilariae were found in a finger prick sample taken from the infant 3 wk after delivery. Our results suggest that microfilariae cross the placenta in less than 10% of pregnancies of microfilaria-positive mothers. Furthermore, the microfilaria count of the mother does not seem to influence directly whether microfilariae are present in the placental blood pool. Although actual transfer of microfilariae to the fetus may occur infrequently, exposure to parasite antigens occurs with much greater frequency. The effect of in utero exposure to either microfilariae or parasite antigens may render newborns tolerant and explain why children born to infected mothers are almost 3 times more likely to become infected than are children born to uninfected women.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Placenta
/
Wuchereria bancrofti
/
Filariasis Linfática
/
Complicaciones Parasitarias del Embarazo
/
Sangre Fetal
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
País/Región como asunto:
Caribe
/
Haiti
Idioma:
En
Revista:
J Parasitol
Año:
1993
Tipo del documento:
Article