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Hydroxyl radical scavengers enhance nitric oxide-evoked acetylcholine release from mouse cerebral cortical neurons.
Ohkuma, S; Katsura, M; Chen, D Z; Guo, J L; Kuriyama, K.
Afiliación
  • Ohkuma S; Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Brain Res Mol Brain Res ; 34(2): 347-50, 1995 Dec 28.
Article en En | MEDLINE | ID: mdl-8750841
The effect of hydroxyl radical scavengers on acetylcholine (ACh) release evoked by nitric oxide (NO) generators and N-methyl-D-aspartate (NMDA) was investigated. Dimethylthiourea enhanced dose-dependently NO generators-evoked ACh release. Similarly, uric acid and mannitol significantly facilitated ACh release evoked by NO generators. The NMDA-induced ACh release was also significantly facilitated by hydroxyl radical scavengers. These scavengers themselves showed no effects on ACh release. These results suggest that hydroxyl radicals may modify the mechanism for NO-evoked ACh release.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilcolina / Corteza Cerebral / Depuradores de Radicales Libres / Radical Hidroxilo / Neuronas / Óxido Nítrico Límite: Animals Idioma: En Revista: Brain Res Mol Brain Res Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 1995 Tipo del documento: Article País de afiliación: Japón
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilcolina / Corteza Cerebral / Depuradores de Radicales Libres / Radical Hidroxilo / Neuronas / Óxido Nítrico Límite: Animals Idioma: En Revista: Brain Res Mol Brain Res Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 1995 Tipo del documento: Article País de afiliación: Japón