Ethanol stimulates diazepam binding inhibitor (DBI) mRNA expression in primary cultured neurons.
Brain Res Mol Brain Res
; 34(2): 355-9, 1995 Dec 28.
Article
en En
| MEDLINE
| ID: mdl-8750843
ABSTRACT
Changes in expression of diazepam binding inhibitor (DBI) mRNA in cerebral cortical neurons following long-term ethanol (EtOH) exposure were examined. A significant increase in DBI mRNA expression was observed by the exposure of neurons to 50 mM EtOH for up to 5 days and to EtOH (1-100 mM) for 3 days. These EtOH-induced increases in DBI mRNA expression were further elevated after the additional cultivation of neurons under EtOH-free condition. beta-Actin mRNA expression was not altered by similar EtOH treatments. These results indicate that EtOH possesses the activity to increase the expression of DBI mRNA in cerebral cortical neurons.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Proteínas Portadoras
/
Corteza Cerebral
/
Etanol
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón