A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.
Virology
; 222(2): 332-8, 1996 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-8806517
ABSTRACT
Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, and D3 receptor binding sites were examined in N. Acc. subregions of normal and infected rats by quantitative receptor autoradiography. The N. Acc. of infected rats had decreased mazindol and D2 and D3 radioligand binding in the core and decreased D3 radioligand binding in rostral subregions. The abnormalities observed in the N. Acc. DA system of infected rats may offer insights into the potential viral pathogenesis of psychiatric conditions with a dopaminergic substrate such as schizophrenia and affective disorders.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Borna
/
Receptores Dopaminérgicos
/
Núcleo Accumbens
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Virology
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos