Multivariate analyses of prognostic factors associated with hematopoietic recovery in autograft patients with different sources of progenitor cells. A GATMO experience. Argintine Group of Bone Marrow Transplant.
Ann Oncol
; 7(7): 719-24, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8905030
ABSTRACT
OBJECTIVE:
To evaluate in a multivariate analysis the prognostic factors associated with hematopoietic recovery and the supportive care requirements after autotransplant of progenitor cells (PC) from various sources bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC alone. PATIENTS ANDMETHODS:
A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherapy and/or cytokines. One-hundred five patients received BMPC, 217 received BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion.RESULTS:
In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001). The factors that adversely affected platelet recovery were low number of nucleated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001).CONCLUSIONS:
We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multiple myeloma and acute leukemia adversely affect both neutrophil and platelet recovery.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Precursoras Eritroides
/
Trasplante de Médula Ósea
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Trasplante de Células Madre Hematopoyéticas
/
Neoplasias Hematológicas
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
/
Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Oncol
Asunto de la revista:
NEOPLASIAS
Año:
1996
Tipo del documento:
Article
País de afiliación:
Argentina