Peroxidase activity may play a role in the cytotoxic effect of indole acetic acid.
Photochem Photobiol
; 65(2): 338-41, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9066308
ABSTRACT
Peroxidase activity in neutrophils is higher than in thioglycollate macrophages, while in lymphocytes this enzyme activity is very low. Indole-3-acetic acid is oxidized by peroxidase and the role of this enzyme in the cytotoxic effect of the compound was evaluated by measuring oxygen consumption, light emission and cell death in neutrophils, macrophages and lymphocytes. The increase in light emission, oxygen consumption and rate of cell death in cells cultured in the presence of indole-3-acetic acid presented a direct correlation with the peroxidase activity of the cells as follows neutrophils > thioglycollate macrophages > resident macrophages > lymphocytes. Indeed, in lymphocytes that possess very low peroxidase activity, indole-3-acetic acid did not result in an increase in light emission or oxygen consumption and it was not cytotoxic.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reguladores del Crecimiento de las Plantas
/
Linfocitos
/
Peroxidasa
/
Ácidos Indolacéticos
/
Macrófagos
/
Neutrófilos
Límite:
Animals
Idioma:
En
Revista:
Photochem Photobiol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil