Trypanocidal flavonoids from Trixis vauthieri.
J Nat Prod
; 60(8): 836-41, 1997 Aug.
Article
en En
| MEDLINE
| ID: mdl-9287419
The crude extract of Trixis vauthieri (Asteraceae) was active against the trypomastigote forms of Trypanosoma cruzi, the protozoan that causes Chagas' disease. Bioassay-guided fractionation of this extract afforded the trypanocidal flavonoids 5,4'-dihydroxy-7-methoxyflavanone (1) and 5,4'-dihydroxy-3,6,7-trimethoxyflavone (2) besides the inactive flavonoids 3,5,4'-trihydroxy-7-methoxyflavanone (3) and 5,4'-dihydroxy-3,6,7,8-tetramethoxy flavone (4). The trypanocidal activity of 1 and 2 and the presence of compounds 2 and 4 in Trixis vauthieri are reported here for the first time.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plantas
/
Tripanocidas
/
Flavonoides
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil