Complementary hydropathy identifies a cellular prion protein receptor.
Nat Med
; 3(12): 1376-82, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9396608
ABSTRACT
Prions, the etiological agents for infectious degenerative encephalopathies, act by entering the cell and inducing conformational changes in PrPC (a normal cell membrane sialoglycoprotein), which result in cell death. A specific cell-surface receptor to mediate PrPC and prion endocytosis has been predicted. Complementary hydropathy let us generate a hypothetical peptide mimicking the receptor binding site. Antibodies raised against this peptide stain the surface of mouse neurons and recognize a 66-kDa membrane protein that binds PrPC both in vitro and in vivo. Furthermore, both the complementary prion peptide and antiserum against it inhibit the toxicity of a prion-derived peptide toward neuronal cells in culture. Such reagents might therefore have therapeutic applications.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Superficie Celular
/
Proteínas PrPC
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil