Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells.
J Neuroimmunol
; 81(1-2): 127-37, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9521614
ABSTRACT
In human astrocytoma cell lines, substance P (SP) stimulated interleukin (IL)-8, IL-6, granulocyte macrophage colony-stimulating factor and leukemia inhibitory factor protein secretion. These SP effects were blocked by a specific NK1 tachykinin receptor antagonist. Further, SP stimulation increased the half-life of IL-6 and IL-8 messenger RNAs, suggesting that the synthesis of these cytokines is also regulated post-transcriptionally. SP-induced cytokine release was inhibited by staurosporine and phorbol 12-myristate 13-acetate desensitization suggesting protein kinase C involvement. The demonstration that SP affects cytokine production in glioma cells might be of relevance for the biology of such tumors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Astrocitoma
/
Neoplasias Encefálicas
/
Sustancia P
/
Citocinas
/
Receptores de Neuroquinina-1
/
Proteínas de Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia