Farnesyltransferase inhibitors versus Ras inhibitors.
Curr Opin Chem Biol
; 1(2): 197-203, 1997 Aug.
Article
en En
| MEDLINE
| ID: mdl-9667853
ABSTRACT
Over the past few years, the idea that farnesyl-protein transferase (FPTase) inhibitors might be effective antiproliferative/antitumor agents has been realized in studies of cultured cells and in rodent models of cancer. Most of the studies with FPTase inhibitors have focused on inhibiting the growth of ras-transformed cells in vitro or the growth of ras-dependent tumors in mice. More recently, it has been recognized that the antiproliferative effect of FPTase inhibitors may extend beyond ras-driven tumors. It now seems likely that the ability of FPTase inhibitors to reverse the malignant phenotype results, at least in part, from inhibiting the farnesylation of proteins other than Ras.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes ras
/
Transferasas Alquil y Aril
/
Inhibidores Enzimáticos
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Chem Biol
Asunto de la revista:
BIOQUIMICA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos