Methyl bromide: 1-year dietary study in dogs.
Food Chem Toxicol
; 36(7): 575-84, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9687964
ABSTRACT
Average human exposure resulting from consumption of methyl bromide (MB)-fumigated food has been estimated to be 0.00125 mg/kg/day. A 1-yr feeding study in beagle dogs was conducted as a safety study, in which the high-dose diet was intended to yield a methyl bromide dose of at least 100 times the calculated human dietary exposure. Diets were fumigated with MB and fed to the dogs daily, except for weekends and holidays. MB consumption each feeding day was calculated as a time weighted average (TWA) that accounted for the rate of degassing from the fumigated diet and the rate of feed consumption during the feeding period. TWA compound consumption in the low-, mid- and high-dose groups, respectively, averaged 0.06 +/- 0.02, 0.13 +/- 0.03 and 0.28 +/- 0.08 mg/kg/day in males and 0.07 +/- 0.03, 0.12 +/- 0.03 and 0.27 +/- 0.09 mg/kg/day in females. Clinical observations, body weight and feed consumption, ophthalmology, clinical pathology, urinalysis, organ weights and macroscopic and microscopic pathology were comparable in control and MB-treated dogs. Under the conditions of this study, the no-observed-effect level (NOEL) for MB was at least 0.28 mg/kg/day, or approximately 200 times the expected average human dietary exposure.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dieta
/
Hidrocarburos Bromados
Límite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos