The absorption of iron is disturbed in recombinant human erythropoietin-treated peritoneal dialysis patients.
Nephrol Dial Transplant
; 13(10): 2578-82, 1998 Oct.
Article
en En
| MEDLINE
| ID: mdl-9794563
ABSTRACT
BACKGROUND:
Intravenous iron supplementation is often necessary in recombinant human erythropoietin (r-HuEPO)-treated haemodialysis (HD) patients, but rarely in r-HuEPO-treated peritoneal dialysis (PD) patients. This may be due to differences in iron absorption or blood loss.METHOD:
Iron absorption (whole-body counting after ingestion of a radiolabelled iron test dose) and iron metabolism were compared in eight iron-replete rHuEPO-treated PD patients (serum ferritin 100-500 microg/l) and 68 healthy iron-replete controls (sufficient iron in bone marrow specimen).RESULTS:
Mucosal uptake (13.4+/-9.8%), mucosal transfer (0.34+/-0.18) and iron retention (4.9+/-4.0) in PD patients was significantly lower than in controls (42.9+/-18.8%, P < 0.0001, 0.63+/-0.18, P < 0.0001, and 28.0+/-16.7%, P<0.0001).CONCLUSION:
Iron absorption is impaired in PD patients, as we have shown previously for HD patients. One reason for higher iron needs in HD patients may be higher blood losses due to the dialysis procedure and blood sampling for laboratory tests.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Eritropoyetina
/
Diálisis Peritoneal
/
Compuestos de Hierro
/
Eritropoyesis
/
Hierro
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nephrol Dial Transplant
Asunto de la revista:
NEFROLOGIA
/
TRANSPLANTE
Año:
1998
Tipo del documento:
Article