Is there an acute-phase response in steady-state sickle cell disease?
Lancet
; 341(8846): 651-3, Mar. 13 1993.
Article
en En
| MedCarib
| ID: med-9591
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; R31.L3
ABSTRACT
Metabolic and serum changes during steady-state homozygous sicle cell (SS) disease are consistent with an acute-phase response and raise the possibility that inflammation occurs in SS disease even during the steady state. To test this hypothesis, we measured concentrations of acute phase reactants in patients with SS disease, in patients with sickle cell haemoglobin C (SC) disease, and in normal (AA) control subjects. The concentrations of C-reactive protein and serum amyloid A were increased above 10 mg/L and 5mg/L, respectively (our definition of an acute-phase response) in 18 percent (26/143) of subjects with SS disease even when they were symptom free, in 17 percent (6/35) of subjects with SC disease, and in 1 percent (1/80) of AA controls (p<0.001). We suggest that subclinical vaso-occlusion may generate a covert inflammatory response and that the cytokine mediators of this response may contribute to the metabolic abnormalities and growth failure in sickle cell disease.(AU)
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Colección:
01-internacional
Banco de datos:
MedCarib
Asunto principal:
Viscosidad Sanguínea
/
Proteínas de Fase Aguda
/
Enfermedad de la Hemoglobina SC
/
Anemia de Células Falciformes
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Lancet
Año:
1993
Tipo del documento:
Article