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1.
Drug Des Devel Ther ; 18: 3659-3666, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39185080

RESUMO

Objective: This randomized, double-blind, placebo-controlled trial aimed to evaluate the efficacy of tranexamic acid essence combined with iontophoresis in treating melasma. Methods: Thirty participants were recruited and randomly assigned to the experimental (Group A) or control group (Group B). Group A received tranexamic acid essence iontophoresis treatment twice weekly for three months, while Group B received placebo treatment. Melasma Area and Severity Index (MASI) scores and skin luminance (L) values were assessed at baseline and weeks 4, 8, and 12. Results: No significant differences in baseline characteristics were observed between the groups. The mean MASI score reduction rate was significantly higher in Group A (-0.10±0.12%) compared to Group B (-0.02±0.09%) (p<0.05). Skin L values significantly increased in Group A from 61.32±3.53 to 63.32±1.78, while slightly decreasing in Group B (p=0.037). Conclusion: Tranexamic acid essence combined with iontophoresis significantly improved MASI scores and skin luminance compared to placebo, demonstrating its effectiveness in treating melasma. Further research with larger sample sizes and longer follow-up is warranted to validate long-term effects and recurrence rates.


Assuntos
Iontoforese , Melanose , Ácido Tranexâmico , Humanos , Ácido Tranexâmico/administração & dosagem , Ácido Tranexâmico/uso terapêutico , Melanose/tratamento farmacológico , Método Duplo-Cego , Feminino , Adulto , Pessoa de Meia-Idade , Masculino , Adulto Jovem , Resultado do Tratamento
2.
J Drugs Dermatol ; 23(8): 691-693, 2024 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-39093647

RESUMO

INTRODUCTION: In an effort to define the characteristics of populations affected by melasma, we utilized a large global health research network database from 108 health care organizations (TriNetx) to quantify the associations between race, ethnicity, and comorbidities. METHODS: We identified the cohort of all patients with melasma from the TriNetx database, and subsequently generated a control cohort. ICD-10 codes were used to identify the prevalence of various comorbidities associated with melasma. RESULTS: A total of 41,283 patients with melasma (93% female, mean [SD] age 48.8 [12.6] year) were identified. The most frequently associated risk factors included hypertension (25% of the melasma cohort) and hormonal contraception (24%). Rosacea (OR=5.1), atopic dermatitis (OR=3.3), lupus (OR=2.5), history of skin cancer (OR=2.5), history of internal malignancy (OR=2.1), and hormonal contraception use (OR=2.1) possessed the highest odds ratios for development of melasma (all P< 0.01). A statistically significant association was identified for melasma in Asian or Other/Unknown races (OR=2.0 and OR=1.7, P< 0.01), as well as Hispanic ethnicity (OR=1.3, P< 0.01). White, Black/African American, and Not Hispanic groups all revealed slightly lower odds (all 0.8, P< 0.01). CONCLUSION: This latest global update on the etiopathology of melasma further supports findings from prior epidemiologic study reporting preference in melanized phenotypes (Fitzpatrick skin type III-V), but less so in extreme skin types (I, II, VI). Increased associations with rosacea, atopic dermatitis, and history of cancer may emphasize the importance of treating concurrent inflammatory environments and the consideration of more frequent malignancy surveillance. J Drugs Dermatol. 2024;23(8):691-693.  doi:10.36849/JDD.8233.


Assuntos
Comorbidade , Melanose , Humanos , Melanose/epidemiologia , Melanose/etnologia , Feminino , Pessoa de Meia-Idade , Masculino , Adulto , Fatores de Risco , Prevalência , Etnicidade/estatística & dados numéricos , Bases de Dados Factuais , Grupos Raciais/estatística & dados numéricos , Rosácea/epidemiologia , Rosácea/etnologia , Rosácea/diagnóstico , Efeitos Psicossociais da Doença , Dermatite Atópica/epidemiologia , Dermatite Atópica/etnologia , Estudos de Coortes
3.
J Int Med Res ; 52(8): 3000605241270648, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39161263

RESUMO

OBJECTIVE: To investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels. METHODS: In this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls. RESULTS: Compared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated. CONCLUSION: POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.


Assuntos
Adiponectina , Resistência à Insulina , Melanose , Deficiência de Vitamina D , Vitamina D , Humanos , Masculino , Feminino , Estudos de Casos e Controles , Projetos Piloto , Melanose/sangue , Melanose/patologia , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/complicações , Adulto , Vitamina D/sangue , Vitamina D/análogos & derivados , Pessoa de Meia-Idade , Adiponectina/sangue , Triglicerídeos/sangue , Leptina/sangue , HDL-Colesterol/sangue , Biomarcadores/sangue
4.
Lasers Med Sci ; 39(1): 216, 2024 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-39141143

RESUMO

This brief report discusses the challenges in treating dermal melanosis and the limitations of current laser treatments due to inadequate tissue penetration and potential side effects. It introduces laser-induced optical breakdown (LIOB) as a novel therapeutic approach using a picosecond laser with a diffractive lens array (DLA) to target dermal pigmentation effectively. LIOB induces multiphoton ionization, leading to melanin clearance through phagocytosis and apoptotic cell removal, while also promoting dermal remodeling and collagen synthesis. We present a case of successful treatment of dermal pigmentation in a 55-year-old woman using 755 nm-picosecond alexandrite laser therapy, demonstrating significant improvement without recurrence. The findings suggest that LIOB offers a promising solution for acquired dermal hypermelanosis by addressing both diffuse and localized pigmentation effectively, leading to skin rejuvenation with minimal downtime and high patient satisfaction.


Assuntos
Lasers de Estado Sólido , Humanos , Feminino , Pessoa de Meia-Idade , Lasers de Estado Sólido/uso terapêutico , Melanose/radioterapia , Melanose/terapia , Melaninas/metabolismo , Terapia com Luz de Baixa Intensidade/métodos , Terapia com Luz de Baixa Intensidade/instrumentação , Rejuvenescimento
5.
Photodermatol Photoimmunol Photomed ; 40(5): e12996, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39149878

RESUMO

BACKGROUND: Dark-skinned individuals (DSI) present high rates of melasma and post-inflammatory hyperpigmentation. The use of sunscreens with mineral filters is essential for prevention and treatment. Our objective was to determine the preferences of dermatologists and dermatology residents in the prescription of sunscreens for DSI. METHODS: An anonymous survey of attendees at an online photoprotection event held on March 31, 2022, in Spain. RESULTS: The survey was answered by 66.6% (221/332) of the attendees: 159 dermatologists (71.9%) and 62 dermatology residents (28.1%). Respondents reported recommending the use of sunscreen to a median of 80% of DSI [interquartile range (IQR), 50-90]. Physicians reported prescribing tinted sunscreens to a median percentage of 60% (IQR, 25-90) of DSI with acne; and to a median percentage of 90% (IQR, 58-99) of DSI with melasma. The most prescribed photoprotectors to DSI with melasma were organic broad-spectrum sunscreens with antioxidants: 102/220 (46.4%) and mineral broad-spectrum sunscreens (with iron oxides): 45/220 (20.4%). In DSI with melasma or other pigmentary disorders, the most preferred features of sunscreens were as follows: sun protection factor ≥ 30: 217/221 (98.2%), UVA protection: 214/221 (96.8%), color for camouflage: 150/220 (68.2%) and mineral filters such as titanium dioxide and zinc oxide: 151/220 (68.6%) or iron oxides: 131/220 (59.5%). LIMITATIONS: Online survey, potential inclusion bias. CONCLUSIONS: Respondents reported to prescribe sunscreens to the majority of DSI, and tinted sunscreens for the majority of DSI with pigmentary disorders. However, the most frequently recommended sunscreens for DSI were organic broad-spectrum sunscreens with antioxidants.


Assuntos
Dermatologistas , Melanose , Pigmentação da Pele , Protetores Solares , Protetores Solares/administração & dosagem , Humanos , Espanha , Feminino , Inquéritos e Questionários , Masculino , Internato e Residência , Adulto , Padrões de Prática Médica/estatística & dados numéricos , Pessoa de Meia-Idade
6.
J Drugs Dermatol ; 23(7): 529-537, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954613

RESUMO

BACKGROUND: Melasma is a chronic pigmentary disorder. In this study, an innovative cream combining cysteamine and tranexamic acid (TXA) was assessed. OBJECTIVE: To evaluate the safety, efficacy, and patient satisfaction of a novel nano-formulated cysteamine and TXA combination cream in treating subjects with epidermal melasma. METHODS:   Fifty (50) randomized subjects participated and received cysteamine and TXA combination cream. The cream was applied for 30 minutes daily for a 3-month duration. Treatment effectiveness, safety, patient satisfaction, and adherence were evaluated. RESULTS: A continuous improvement in melasma was observed, with modified Melasma Area and Severity Index (mMASI) scores improving by 40%, 57%, and 63% at 30, 60, and 90 days, respectively. The primary endpoint of a decrease in mMASI scores was met, with 91% of participants experiencing melasma improvement. Patient Satisfaction and Patient Adherence scores indicated satisfaction. Convenience exhibited the strongest correlation with patient adherence.  Conclusion: Nano-formulated cysteamine and TXA combination cream showed significant efficacy in decreasing mMASI score while demonstrating a strong safety profile and patient satisfaction.  J Drugs Dermatol. 2024;23(7):529-537.     doi:10.36849/JDD.7765R1.


Assuntos
Cisteamina , Adesão à Medicação , Melanose , Satisfação do Paciente , Ácido Tranexâmico , Humanos , Melanose/tratamento farmacológico , Melanose/diagnóstico , Cisteamina/administração & dosagem , Cisteamina/efeitos adversos , Ácido Tranexâmico/administração & dosagem , Ácido Tranexâmico/efeitos adversos , Feminino , Adulto , Resultado do Tratamento , Pessoa de Meia-Idade , Masculino , Creme para a Pele/administração & dosagem , Creme para a Pele/efeitos adversos , Administração Cutânea , Índice de Gravidade de Doença , Combinação de Medicamentos , Nanopartículas/administração & dosagem , Adulto Jovem
7.
J Drugs Dermatol ; 23(7): 510-514, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954622

RESUMO

BACKGROUND: The prevalence of social media as a source of medical information has grown substantially in recent years, especially for skin conditions disproportionately affecting individuals with skin of color, such as melasma, keloids, and vitiligo. OBJECTIVE: This study aims to evaluate the nature of content related to these conditions on social media platforms, Instagram and TikTok. METHODS: In March 2023, the top five hashtags for melasma, keloid, and vitiligo were identified on both platforms. For each hashtag, the 10 most popular posts were selected, based on Instagram and TikTok algorithms. A content analysis was conducted, categorizing posts as Educational, Promotional, or Inspirational. Posts were further classified by content creator type. RESULTS: For the top 50 posts related to melasma on Instagram, the majority were promotional (58%), with the most common source being non-dermatologist social media influencers (50%). Dermatologists were the primary content creators for specific hashtags, such as #Melasma on TikTok, where the content was predominantly educational. CONCLUSION: Considering the high prevalence of dermatologist-creator content on TikTok, it is crucial to continue this shift toward dermatologist-driven educational content, as social media platforms continue to grow. These platforms are valuable channels for dermatologists to educate a broader audience, facilitating the dissemination of accurate medical information.J Drugs Dermatol. 2024;23(7):510-514. doi:10.36849/JDD.7716.


Assuntos
Queloide , Melanose , Pigmentação da Pele , Mídias Sociais , Vitiligo , Mídias Sociais/estatística & dados numéricos , Humanos , Vitiligo/terapia , Vitiligo/diagnóstico , Vitiligo/psicologia , Queloide/epidemiologia , Melanose/diagnóstico , Dermatologistas/estatística & dados numéricos
8.
Cutis ; 113(6): 264-268, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-39082993

RESUMO

Melasma is a common acquired hyperpigmentation disorder that affects mostly women and individuals with darker skin types. Oxidative stress may play a role in the pathogenesis of melasma. Dynamic thiol/disulfide homeostasis is one of the most important indicators of oxidative stress. This study aimed to investigate the presence of oxidative stress in patients with melasma by evaluating thiol/disulfide homeostasis. Sixty-seven patients with melasma and 41 healthy age- and sex-matched controls were included in the study. Disease severity was evaluated using the modified melasma area and severity index (mMASI). Thiol/disulfide homeostasis parameters of the melasma and control groups were measured using a novel, fully automated spectrophotometric method. Our data indicated the presence of oxidative stress in melasma, which may be correlated with disease severity. Because research on the presence of oxidative stress in melasma is limited, further studies are needed to support these conclusions.


Assuntos
Dissulfetos , Homeostase , Melanose , Estresse Oxidativo , Índice de Gravidade de Doença , Compostos de Sulfidrila , Humanos , Melanose/metabolismo , Feminino , Compostos de Sulfidrila/metabolismo , Adulto , Homeostase/fisiologia , Masculino , Estudos de Casos e Controles , Pessoa de Meia-Idade , Espectrofotometria
9.
Zhongguo Zhong Yao Za Zhi ; 49(13): 3552-3565, 2024 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-39041127

RESUMO

Based on UHPLC-Q-Exactive Orbitrap HRMS coupled with the network pharmacology and molecular docking, the common material basis and molecular mechanisms of Bletillae Rhizoma for melasma, gastrointestinal hemorrhage, lung cancer and bronchoplumonary inflammation as "homotherapy for heteropathy" were explored. The fingerprint of 17 batches of Bletillae Rhizoma from different areas was established using HPLC, and the similarity analysis was carried out. The common chemical components of the 17 batches of Bletillae Rhizoma were identified using UHPLC-Q-Exactive Orbitrap HRMS. Depending on the bioavailability and drug-like properties of the common components, the active chemical components were screened, and then their protein targets were collected using the Traditional Chinese Medicine Database and Analysis Platform(TCMSP) and SwissTargetPrediction database. The protein targets related to diseases were retrieved from the databases DrugBank, TTD and GeneCards to produce a Venn diagram. The shared targets were obtained between drugs and diseases as "homotherapy for heteropathy" targets. The protein-protein interaction(PPI) was analyzed with the STRING database, and KEGG and GO analyses of the "homotherapy for heteropathy" targets were performed using the Bioconductor database. Cytoscape 3.7.2 software was employed to construct the "chemical components of Bletillae Rhizoma-homotherapy for heteropathy targets" network and PPI network, and topological analysis was conducted to screen out the key active chemical components and core targets. Finally, the affinity between the active components and core targets was evaluated using the molecular docking by AutoDock Vina 4.2.6, which verified the interaction between them. Thirteen common peaks were identified by fingerprint chromatography, and the similarity between different batches was 0.941-0.998. Fifty-three chemical components were identified by mass spectrometry in Bletillae Rhizoma, and 18 common chemical constituents were obtained in the 17 batches of Bletillae Rhizoma. Network pharmacologic screening showed that the pharmacodynamic substances of Bletillae Rhizoma for melasma, gastrointestinal hemo-rrhage, lung cancer and bronchoplumonary inflammation with "homotherapy for heteropathy" were 11 compounds, such as polysaccharides, biphenanthrenes, dihydrophenanthrenes and bibenzyls. There were 42 common targets identified for the treatment of different diseases. These targets were involved in biological processes such as cell response to chemical stress, reactive oxygen species and positive regulation of protein kinase B signal transduction. They were also involved in 121 signaling pathways, encompassing vital pathways such as PI3K-Akt, ErbB, Rap1, FoxO, MAPK and estrogen. Molecular docking results showed a strong affinity between the key active components and the core targets. This study provides a preliminary explanation of how Bletillae Rhizoma exerts its therapeutic effect on chloasma, gastrointestinal hemorrhage, lung cancer, and bronchopneumonic lesions as "homotherapy for heteropathy" through a combined action involving multiple components, targets, and pathways. These findings offer a certain theoretical basis for the further deve-lopment and application of Bletillae Rhizoma.


Assuntos
Medicamentos de Ervas Chinesas , Neoplasias Pulmonares , Simulação de Acoplamento Molecular , Farmacologia em Rede , Rizoma , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Humanos , Cromatografia Líquida de Alta Pressão , Rizoma/química , Neoplasias Pulmonares/tratamento farmacológico , Hemorragia Gastrointestinal/tratamento farmacológico , Melanose/tratamento farmacológico , Orchidaceae/química , Inflamação/tratamento farmacológico , Espectrometria de Massas
10.
Am J Clin Dermatol ; 25(5): 717-733, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38896402

RESUMO

Melasma is a chronic, acquired disorder of focal hypermelanosis that carries significant psychosocial impact and is challenging for both the patient and the treating practitioner to manage in the medium to long term. Multiple treatments have been explored, often in combination given the many aetiological factors involved in its pathogenesis. Therapeutic discoveries to treat melasma are a focal topic in the literature and include a range of modalities, with recent developments including updates on visible light photoprotection, non-hydroquinone depigmenting agents, oral tranexamic acid, chemical peels, and laser and energy-based device therapy for melasma. It is increasingly important yet challenging to remain up-to-date on the arsenal of treatments available for melasma to find an efficacious and well-tolerated option for our patients.


Assuntos
Abrasão Química , Melanose , Ácido Tranexâmico , Melanose/terapia , Melanose/diagnóstico , Humanos , Abrasão Química/métodos , Ácido Tranexâmico/uso terapêutico , Terapia a Laser/métodos , Resultado do Tratamento , Preparações Clareadoras de Pele/uso terapêutico , Preparações Clareadoras de Pele/administração & dosagem , Fármacos Dermatológicos/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Terapia com Luz de Baixa Intensidade/instrumentação
11.
Lasers Surg Med ; 56(6): 551-556, 2024 08.
Artigo em Inglês | MEDLINE | ID: mdl-38890816

RESUMO

OBJECTIVES: Freckles and lentigines are common pigmented problems which not only cause substantial cosmetic morbidity but also create psychosocial concern. The available modalities for the treatment of pigmented lesions are often unsatisfactory for patients, require a long treatment period, and often cause skin irritation. With the advent of lasers, safe and effective treatment options for epidermal pigmentation have become more varied for different Fitzpatrick skin types. We aimed to evaluate the efficacy and safety of 577-nm yellow laser in the treatment of pigmented epidermal lesions. METHODS: This study was carried out on 50 patients presented with pigmented epidermal lesions (25 presented with freckles and 25 presented with lentigines). Each patient received four treatment sessions with a 577-nm diode laser at 2-week intervals. RESULTS: There was significant improvement in freckles and lentigines, as 23 out of 50 patients showed marked improvement, 11 patients showed moderate improvement, 10 patients showed mild improvement, and only six patients had no changes. Moreover, 23 patients were very satisfied, 18 patients were satisfied, and nine patients were not satisfied. As regards the safety of the 577-nm yellow laser, there was no significant adverse effect among patients except pain, erythema, and hyperpigmentation, which resolved within one month after treatment. CONCLUSIONS: This study showed that the 577-nm yellow laser is an effective, safe, and well-tolerated device in the treatment of freckles and lentigines.


Assuntos
Lasers Semicondutores , Lentigo , Humanos , Feminino , Adulto , Masculino , Pessoa de Meia-Idade , Lasers Semicondutores/uso terapêutico , Adulto Jovem , Lentigo/cirurgia , Resultado do Tratamento , Adolescente , Melanose/radioterapia , Satisfação do Paciente , Terapia com Luz de Baixa Intensidade/métodos
12.
Arch Dermatol Res ; 316(7): 378, 2024 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-38850450

RESUMO

Hydroquinone has been used for years for multiple conditions, including melasma, post-inflammatory hyperpigmentation, dyschromia from photoaging, and solar lentigines. It is known to be a very effective lightening agent, but several concerns have been raised about this widely used agent. The recent U.S. ban on over-the-counter skin lightening products containing hydroquinone has prompted further questioning of the safety of this widely used agent. While there have been prior informative, large-scale reviews on the safety of hydroquinone, new findings have since been reported. Here, we provide an updated review of studies published in the past 15 years on hydroquinone safety.


Assuntos
Hidroquinonas , Preparações Clareadoras de Pele , Hidroquinonas/efeitos adversos , Humanos , Preparações Clareadoras de Pele/efeitos adversos , Hiperpigmentação/induzido quimicamente , Melanose/tratamento farmacológico , Envelhecimento da Pele/efeitos dos fármacos
13.
Eur J Dermatol ; 34(2): 131-138, 2024 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-38907542

RESUMO

The clinical diagnosis of pigmented genital lesions is challenging. Reflectance confocal microscopy (RCM) is effective for diagnosis but is limited in its application due to elevated costs. A more affordable dermatoscope with a 400x magnification (D400) has recently been brought to market. The aim of our study was to compare these two imaging techniques for the analysis of pigmented genital tumours. An observational, prospective and mono-centric study was carried out from October 2017 to May 2019, in which clinical, dermatoscopic (20x and 400x) and RCM data from 207 pigmented genital lesions were collected. The images generated via D400 and RCM were analysed by three expert investigators. Similarities between the criteria observed using D400 and RCM were evaluated by each investigator. In total, 207 lesions were included: 183 melanosis, 19 nevi, one basal cell carcinoma (BCC), two condylomas and two melanomas in situ. Our series correlates well with data found in the literature especially for the distribution of different lesions, their topography, and their aspect using x20 dermatoscopy and RCM. Pattern and cell criteria defined using RCM largely paralleled those observed with D400 for all three investigators. Correlation between D400 and RCM was moderate to strong with regards to the identification of the ring pattern and clustered round cells, strong for dendritic and plump cells, and perfect for isolated round cells and spindle cells. D400 is an easy-to-use, cost-effective alternative for the analysis of pigmented genital lesions, particularly for melanosis.


Assuntos
Dermoscopia , Melanose , Microscopia Confocal , Neoplasias Cutâneas , Humanos , Microscopia Confocal/métodos , Melanose/diagnóstico por imagem , Melanose/patologia , Estudos Prospectivos , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/diagnóstico por imagem , Feminino , Masculino , Melanoma/diagnóstico por imagem , Melanoma/patologia , Carcinoma Basocelular/diagnóstico por imagem , Carcinoma Basocelular/patologia , Pessoa de Meia-Idade , Adulto , Condiloma Acuminado/diagnóstico por imagem , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/patologia , Nevo Pigmentado/diagnóstico por imagem , Nevo Pigmentado/patologia , Idoso , Doenças dos Genitais Femininos/diagnóstico por imagem , Doenças dos Genitais Femininos/patologia , Nevo/diagnóstico por imagem , Nevo/patologia
14.
J Dermatolog Treat ; 35(1): 2361106, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38843906

RESUMO

Purpose: This study aimed to evaluate the efficacy of tranexamic acid (TXA) in treating melasma through a meta-analysis and systematic review of randomized controlled trials (RCTs). The study focused on identifying associated adverse effects and comparing TXA's effectiveness with other melasma treatments.Materials and methods: Following PROSPERO and PRISMA guidelines, an extensive electronic search was conducted across four databases for RCTs on TXA use in melasma. Inclusion criteria encompassed full-text English articles with specific outcome measures, while studies with high bias risk or non-English publications were excluded. Data were extracted from 22 relevant studies and analyzed using the RevMan software, with heterogeneity identified using I² statistics and forest plots.Results: A total of 22 studies with 1280 patients were included. TXA was administered orally, topically, or via injection, with treatment durations ranging from 8 weeks to nearly 2 years. TXA significantly reduced melasma severity, evidenced by reductions in MASI, mMASI, MI, and hemi-MASI scores. Oral TXA showed the most substantial decrease in MASI scores, followed by injections and topical applications. However, studies exhibited high heterogeneity, particularly in combined treatments. Adverse effects included gastrointestinal discomfort, skin irritation, and menstrual irregularities.Conclusions: TXA is effective in treating melasma, either alone or combined with other treatments. Despite significant reductions in melasma severity, further research is necessary to standardize TXA administration methods and address long-term effects. The high heterogeneity observed suggests a need for more consistent treatment protocols.


Assuntos
Melanose , Ácido Tranexâmico , Humanos , Administração Cutânea , Administração Oral , Antifibrinolíticos/uso terapêutico , Antifibrinolíticos/administração & dosagem , Melanose/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Índice de Gravidade de Doença , Ácido Tranexâmico/uso terapêutico , Ácido Tranexâmico/administração & dosagem , Resultado do Tratamento
15.
J Drugs Dermatol ; 23(6): e151-e153, 2024 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-38834215

RESUMO

BACKGROUND: Melasma and post-inflammatory hyperpigmentation (PIH) are common cosmetic dermatologic conditions that predominantly affect patients with skin phototypes III-VI. Comparing treatment coverage for these pigmentary disorders to treatment coverage for acne vulgaris may demonstrate disparities in insurance coverage for diseases that primarily affect patients of color. OBJECTIVE: Describe differences in Medicaid coverage for topical tretinoin for melasma and PIH vs. acne vulgaris in all 50 states and the District of Columbia. METHODS: This is a cross-sectional study of Medicaid insurance plans in all 50 states and the District of Columbia conducted between February 1 and 28, 2023. Data was collected from online publicly available preferred drug lists, prior authorization criteria, and email/telephone inquiries. Information was collected regarding coverage restrictions, including age restrictions, diagnostic restrictions, preferred drug status, and prior authorization requirements. RESULTS: Complete coverage data for all three clinical indications was retrieved from 30 (58.8%) states; partial coverage data for acne vulgaris was retrieved from 16 (31.4%) states; no coverage data was retrieved from 5 (9.8%) states. Of states reporting coverage data, topical tretinoin is covered in 45 (97.8%) states for acne vulgaris and 10 (33.3%) states for melasma and post-inflammatory hyperpigmentation. There was decreased Medicaid coverage of topical tretinoin for acne vulgaris compared to melasma and PIH (P<0.05).  Conclusion: There is differential Medicaid coverage for acne vulgaris compared to pigmentary disorders which disproportionately affect patients of color. Greater advocacy is required to ensure equal treatment for conditions that affect racial minority patients. J Drugs Dermatol. 2024;23(6):e151-e153.     doi:10.36849/JDD.8069e  .


Assuntos
Acne Vulgar , Cobertura do Seguro , Medicaid , Tretinoína , Humanos , Estados Unidos , Acne Vulgar/tratamento farmacológico , Tretinoína/administração & dosagem , Tretinoína/economia , Medicaid/estatística & dados numéricos , Estudos Transversais , Cobertura do Seguro/estatística & dados numéricos , Hiperpigmentação/tratamento farmacológico , Disparidades em Assistência à Saúde/economia , Feminino , Ceratolíticos/administração & dosagem , Ceratolíticos/economia , Melanose/tratamento farmacológico , Masculino
16.
Artigo em Inglês | MEDLINE | ID: mdl-38918942

RESUMO

INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brown patches with a symmetrical distribution, primarily on sun-exposed areas such as the face. Topical hydroquinone (HQ) is the gold standard for melasma treatment but has numerous side effects. This study assesses the effectiveness of topical tranexamic acid (TA) as an alternative for melasma treatment. METHODS: In a double-blind, split-face, randomized controlled trial involving 20 subjects, the effectiveness of 3% TA versus 4% HQ cream was evaluated over 8 weeks. The modified melasma area and severity index (mMASI), melanin index, erythema index, and side effects were assessed. Subjective improvement was measured using the patient global assessment (PtGA). RESULTS: A significant decline in the mMASI score was observed at weeks 4 and 8 in both groups compared to baseline. There were no statistically significant differences in PtGA scores between the 3% TA group and the 4% HQ group. CONCLUSIONS: Topical 3% TA is as effective and safe as 4% HQ for treating melasma in the Indonesian population, with potential advantages in terms of side-effect profiles.


Assuntos
Hidroquinonas , Melanose , Ácido Tranexâmico , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Administração Cutânea , Método Duplo-Cego , Hidroquinonas/administração & dosagem , Hidroquinonas/efeitos adversos , Hidroquinonas/uso terapêutico , Melanose/tratamento farmacológico , Índice de Gravidade de Doença , Creme para a Pele/uso terapêutico , Ácido Tranexâmico/administração & dosagem , Ácido Tranexâmico/uso terapêutico , Resultado do Tratamento
19.
J Cosmet Dermatol ; 23(9): 2785-2792, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38693699

RESUMO

BACKGROUND: The exact pathogenesis of melasma is not yet known, and its treatment remains challenging. Mesotherapy with tranexamic acid (TXA) and vitamin C was both reported to have certain effects on melasma. In spite of that several articles have compared the efficacy and safety of the two drugs on melasma, most of them were clinical study with small sample size. AIMS: To evaluate the efficacy and safety of mesotherapy with TXA versus vitamin C in treating melasma through meta-analysis and systemic review. METHODS: The authors searched PubMed, Web of Science, Springer, and ScienceDirect for studies that compared mesotherapy with TXA versus vitamin C as a treatment for melasma. Primary outcomes were change in melasma area and severity index (MASI) before and after the treatment. RESULTS: Finally, five studies with a total of 127 patients were included in the systematic review. There was no statistic difference in the change in MASI score between the TXA and vitamin C groups (mean difference, 0.16; 95% CI, -0.79 to 1.11). CONCLUSIONS: Mesotherapy with both TXA and vitamin C is safe and effective in the treatment of melasma.


Assuntos
Ácido Ascórbico , Melanose , Mesoterapia , Ácido Tranexâmico , Humanos , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/efeitos adversos , Melanose/diagnóstico , Melanose/tratamento farmacológico , Mesoterapia/efeitos adversos , Mesoterapia/métodos , Índice de Gravidade de Doença , Ácido Tranexâmico/administração & dosagem , Ácido Tranexâmico/efeitos adversos , Resultado do Tratamento
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