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1.
Nutrients ; 16(17)2024 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-39275187

RESUMO

Considering the widespread issue of distracted eating, our study investigates how cognitive distraction influences the sensory perception of food-related odors among individuals with varying weight statuses. We conducted an exploratory, randomized, and cross-sectional experimental study, using the Tetris game to simulate real-life cognitive distraction, incorporating two distraction levels (low and high) and presenting five distinct odors. A total of 59 participants, categorized into a lean (n = 30) and overweight/obese group (n = 29) based on their body mass index (BMI), received odor stimuli while playing Tetris at low and high difficulty, corresponding to low and high distraction levels, respectively. Participants subsequently rated odor intensity and pleasantness under the two cognitive distraction conditions. Respiratory movements were monitored to ensure accurate olfactory stimulation. Our findings revealed no significant difference in odor intensity ratings across distraction levels (p = 0.903). However, there was a significant reduction in odor pleasantness under high cognitive distraction (p = 0.007), more pronounced in lean participants compared to those with an overweight status (p = 0.035). Additionally, an interaction between gender and cognitive distraction effects was observed in odor pleasantness perception. The differential effects of distraction across weight-status groups and genders are discussed in the context of hedonic motivation and compensatory mechanisms. This study sheds light onto the sensory mechanisms underlying distracted eating and could inform more personalized strategies for promoting healthier eating habits in a world dominated by distractions.


Assuntos
Cognição , Comportamento Alimentar , Odorantes , Sobrepeso , Humanos , Feminino , Masculino , Adulto Jovem , Adulto , Cognição/fisiologia , Comportamento Alimentar/psicologia , Comportamento Alimentar/fisiologia , Estudos Transversais , Sobrepeso/psicologia , Atenção/fisiologia , Peso Corporal , Índice de Massa Corporal , Percepção Olfatória , Obesidade/psicologia , Ingestão de Alimentos/fisiologia , Ingestão de Alimentos/psicologia , Prazer , Adolescente
2.
Nutrients ; 16(17)2024 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-39275268

RESUMO

Avoidant/restrictive food intake disorder (ARFID) includes age-inappropriate feeding behaviors in eating patterns, including food neophobia, defined as refusal or reluctance to eat new or unknown foods. This study aimed to assess the prevalence of ARFID and food neophobia among adults and determine the related characteristics of these risks. The study used an anonymous survey questionnaire consisting of three parts as the research tool. The first part of the questionnaire was a metric and concerned socio-demographic data. The Food Neophobia Scale (FNS) and the Nine-Item Avoidance/Restrictive Food Disorder Screen Questionnaire (NIAS) were used to evaluate the eating disorders. The survey included 309 people (60.2% women, 39.8% men) aged 18-77 years. NIAS results indicated that 15.2% of the subjects showed food selectivity, and 11.0% had food anxiety. In the FNS assessment, 42.4% had a low risk of food neophobia, 38.2% a medium risk, and 19.4% a high risk. A higher risk of food neophobia correlated with higher NIAS scores, indicating a higher risk of ARFID (p = 0.00231). The NIAS score increased with the risk of food neophobia (p = 0.000). Respondents at low risk of neophobia were most likely to avoid several products (83.97%), while in the high-risk group, 56.67% did not want to eat a favorite food enriched with a new ingredient. A higher risk of neophobia was correlated with more food avoidance and adverse reactions to new foods (p = 0.000). A higher risk of food neophobia is strongly correlated with a higher risk of ARFID. Although demographics did not significantly impact NIAS results, some trends were noted, such as higher scores among older and underweight people. Those with a higher risk of food neophobia show more food avoidance and a greater reluctance to experiment with new ingredients. Public education should emphasize that eating disorders affect both sexes equally, with tailored interventions for high-risk groups such as the elderly, rural populations, and those with lower education. Health policies should promote access to nutrition education, psychological support, and diverse food options, while further research is needed to improve targeted interventions.


Assuntos
Transtorno Alimentar Restritivo Evitativo , Comportamento Alimentar , Humanos , Adulto , Feminino , Pessoa de Meia-Idade , Masculino , Idoso , Adulto Jovem , Adolescente , Inquéritos e Questionários , Comportamento Alimentar/psicologia , Prevalência , Preferências Alimentares/psicologia , Ingestão de Alimentos/psicologia , Fatores de Risco , Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia , Transtornos da Alimentação e da Ingestão de Alimentos/psicologia
3.
Nutrients ; 16(17)2024 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-39275292

RESUMO

A conventional questionnaire-based assessment of acetic acid intake is based on the intake of seasonings such as mayonnaise, which could thereby lead to an underestimation. We here determine the relationships of acetic acid intake with nutrient intake estimated using a food recording app (Asken) based on meal recipes. A total of 141 individuals (48 men and 93 women) used the app for at least 7 days per month. The mean daily intake of acetic acid was 0.16 ± 0.19 g and the mean frequency of acetic acid intake was 2.77 ± 1.66 days per week. A multivariate regression analysis adjusted for age, sex, BMI, and energy intake revealed that the amount of acetic acid consumed was significantly and positively associated with the intake of protein (11.9 (5.1, 18.6), p < 0.001), cholesterol (80.7 (4.5, 156.9), p = 0.04), and all vitamins except vitamin K. The frequency of acetic acid intake was significantly and positively associated with protein (1.04 (0.20, 1.87), p = 0.015), vitamin B1 (0.3 (0.02,0.5), p = 0.031), niacin (0.5 (0.04,1.0), p = 0.032), and vitamin B12 (0.4 (0.1,0.7), p = 0.002) intake, suggesting that individuals who frequently consume acetic acid tend to consume more protein and some vitamins. Thus, the amount and frequency of acetic acid may reflect protein and vitamin intake.


Assuntos
Ácido Acético , Proteínas Alimentares , Vitaminas , Humanos , Feminino , Masculino , Ácido Acético/administração & dosagem , Proteínas Alimentares/administração & dosagem , Pessoa de Meia-Idade , Vitaminas/administração & dosagem , Adulto , Registros de Dieta , Idoso , Aplicativos Móveis , Dieta/estatística & dados numéricos , Ingestão de Alimentos
4.
Nutrients ; 16(17)2024 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-39275326

RESUMO

Rugby union is an intermittent team sport with variability in body composition and match-play demands between positions which requires careful consideration for individual dietary requirements. While previous reviews have detailed the macronutrient intake in rugby players, none have discussed the further determinants of dietary intake in this population. Therefore, the purpose of the current review was to summarise the current evidence detailing dietary intake in rugby union players, report on contemporary nutritional research themes, and provide recommendations for athletes, nutritionists, and other stakeholders. In total, eighteen articles report on dietary intake in rugby players, with only one of these detailing dietary intake in female athletes. Recent studies have reported on both protein and carbohydrate periodisation practices in rugby union players; however, there is currently limited evidence as to the influence of these on performance, recovery, and well-being. Factors influencing eating patterns, the impact of sports nutritionists on dietary intake, and food consumption in catered and non-catered environments has been explored in isolated studies. Nutrition knowledge levels in rugby players have been reported in several studies; however, the influence this has on dietary intake in rugby players is unknown. Collectively, despite new contemporary themes emerging in the literature concerning dietary intake in rugby players, the studies are isolated; as such, there is limited scope to the translatability of information due to heterogeneity in sex, level of play, and location of participants. Given this, future research should aim to build upon the themes identified in this review in combination to support practitioners working within their specific environments. This will subsequently build towards the generation of rugby-specific recommendations.


Assuntos
Futebol Americano , Humanos , Futebol Americano/fisiologia , Feminino , Dieta , Fenômenos Fisiológicos da Nutrição Esportiva , Masculino , Atletas/psicologia , Comportamento Alimentar/fisiologia , Proteínas Alimentares/administração & dosagem , Ingestão de Alimentos/fisiologia , Necessidades Nutricionais , Carboidratos da Dieta/administração & dosagem , Composição Corporal , Ingestão de Energia , Rugby
5.
Nutrients ; 16(17)2024 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-39275328

RESUMO

The psychological states of hunger and satiety play an important role in regulating human food intake. Several lines of evidence suggest that these states rely upon declarative learning and memory processes, which are based primarily in the medial temporal lobes (MTL). The MTL, and particularly the hippocampus, is unusual in that it is especially vulnerable to insult. Consequently, we examine here the impact on hunger and satiety of conditions that: (1) are central to ingestive behaviour and where there is evidence of MTL pathology (i.e., habitual consumption of a Western-style diet, obesity, and anorexia nervosa); and (2) where there is overwhelming evidence of MTL pathology, but where ingestive behaviour is not thought central (i.e., temporal lobe epilepsy and post-traumatic stress disorder). While for some of these conditions the evidence base is currently limited, the general conclusion is that MTL impairment is linked, sometimes strongly, to dysfunctional hunger and satiety. This focus on the MTL, and declarative learning and memory processes, has implications for the development of alternative treatment approaches for the regulation of appetite.


Assuntos
Fome , Saciação , Humanos , Fome/fisiologia , Saciação/fisiologia , Obesidade/psicologia , Obesidade/fisiopatologia , Comportamento Alimentar/psicologia , Comportamento Alimentar/fisiologia , Lobo Temporal/fisiopatologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Transtornos de Estresse Pós-Traumáticos/fisiopatologia , Epilepsia do Lobo Temporal/fisiopatologia , Epilepsia do Lobo Temporal/psicologia , Anorexia Nervosa/psicologia , Anorexia Nervosa/fisiopatologia , Memória/fisiologia , Hipocampo/fisiologia , Aprendizagem , Ingestão de Alimentos/psicologia , Ingestão de Alimentos/fisiologia , Dieta Ocidental/efeitos adversos
6.
Nutrients ; 16(17)2024 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-39275345

RESUMO

BACKGROUND: Emotional eating is associated with adverse health outcomes in children, including elevated weight status. Currently, there is not a well-validated parent-report measure of emotional eating for young children. This study assessed the reliability and validity of the 10-item parent version of the Emotional Eating Scale Adapted for Children and Adolescents (EES-C) Short-Form. METHODS: The participants were 207 parents and 144 children from the southern United States. They completed the parent- and child-report EES-C Short-Form and responded to measures related to child eating behaviors, mood, and gratitude. RESULTS: The parent-report EES-C Short-Form demonstrated good internal consistency reliability (Cronbach's alpha = 0.94). Test-retest reliability was also supported, as evidenced by a medium correlation (ICC = 0.56, p < 0.001) between parent-rated emotional eating across two time points. Additionally, the measure demonstrated a significant correlation with a scale of emotional overeating (r = 0.25, p < 0.001)-a theoretically related construct. Supporting discriminant validity, the measure was not significantly related to a measure of parent-reported gratitude (r = 0.07, p = 0.30). A unidimensional model provided good fit for the data (CFI = 0.997, SRMR = 0.046). CONCLUSIONS: The results from the current study provide preliminary evidence supporting the reliability and validity of the parent version of the EES-C Short-Form. For the purpose of screening children in school or primary care settings, the EES-C Short-Form may be practical and helpful in identifying children who may be at risk of developing adverse health outcomes or more-severe eating disorder pathology.


Assuntos
Emoções , Comportamento Alimentar , Pais , Psicometria , Humanos , Criança , Feminino , Masculino , Pais/psicologia , Reprodutibilidade dos Testes , Comportamento Alimentar/psicologia , Adolescente , Inquéritos e Questionários/normas , Adulto , Comportamento Infantil/psicologia , Ingestão de Alimentos/psicologia
7.
Nihon Ronen Igakkai Zasshi ; 61(3): 291-295, 2024.
Artigo em Japonês | MEDLINE | ID: mdl-39261098
12.
Support Care Cancer ; 32(10): 651, 2024 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-39256281

RESUMO

PURPOSE: Metallic taste (MT) is frequently observed during head and neck cancer treatments, but very little is known about its impact on nutritional status. The aim of this study was to explore the impact of MT on the quality of life and nutritional status in patients with head and neck cancer expressing MT. METHODS: Questionnaires on quality of life, MT, weight, and food intake were filled out by 44 patients with head and neck cancer before, during, and up to 1 year after their treatment. Patients were divided into two groups based on their reported experience of MT. RESULTS: MT was commonly observed (n = 12, 27.2%), always during the treatment phase, and mostly linked with radiotherapy or radiochemotherapy. Reported MT intensity was moderate (n = 6, 40%) to high (n = 4, 26.7%). MT had a significant negative impact on quality of life linked to dysgeusia (p = 0.025). The negative impacts of MT on food intake and on weight were not significant, possibly due to a combination of sample size, dropouts, and duration of observation. Further research in this area could provide additional insights into how to better address the issue related to MT and enhance the quality of care provided to this patient population. CONCLUSION: Metallic taste, experienced by 27.2% of the 44 patients with head and neck cancer, contributes to dysgeusia and results in a significant decline in quality of life associated with dysgeusia. TRIAL REGISTRATION: ClinicalTrials.gov trial registration number: NCT03558789.


Assuntos
Disgeusia , Neoplasias de Cabeça e Pescoço , Estado Nutricional , Qualidade de Vida , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Inquéritos e Questionários , Disgeusia/etiologia , Disgeusia/epidemiologia , Adulto , Ingestão de Alimentos/fisiologia , Idoso de 80 Anos ou mais , Paladar , Distúrbios do Paladar/etiologia
13.
Nat Commun ; 15(1): 7728, 2024 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-39231981

RESUMO

To ensure survival, animals must sometimes suppress fear responses triggered by potential threats during feeding. However, the mechanisms underlying this process remain poorly understood. In the current study, we demonstrated that when fear-conditioned stimuli (CS) were presented during food consumption, a neural projection from lateral hypothalamic (LH) GAD2 neurons to nucleus incertus (NI) relaxin-3 (RLN3)-expressing neurons was activated, leading to a reduction in CS-induced freezing behavior in male mice. LHGAD2 neurons established excitatory connections with the NI. The activity of this neural circuit, including NIRLN3 neurons, attenuated CS-induced freezing responses during food consumption. Additionally, the lateral mammillary nucleus (LM), which received NIRLN3 projections, along with RLN3 signaling in the LM, mediated the decrease in freezing behavior. Collectively, this study identified an LHGAD2-NIRLN3-LM circuit involved in modulating fear responses during feeding, thereby enhancing our understanding of how animals coordinate nutrient intake with threat avoidance.


Assuntos
Medo , Animais , Medo/fisiologia , Masculino , Camundongos , Hipotálamo/fisiologia , Hipotálamo/metabolismo , Relaxina/metabolismo , Neurônios/fisiologia , Neurônios/metabolismo , Camundongos Endogâmicos C57BL , Vias Neurais/fisiologia , Ingestão de Alimentos/fisiologia , Condicionamento Clássico/fisiologia , Região Hipotalâmica Lateral/fisiologia , Região Hipotalâmica Lateral/metabolismo
14.
S Afr Fam Pract (2004) ; 66(1): e1-e4, 2024 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-39221726

RESUMO

BACKGROUND:  Physicians often focus on possible cardiac causes in patients presenting with chest pain. However, this case highlights a patient who presented with chest pain caused by ingestion of a foreign body after an uneventful meal eaten an hour prior to presentation. The fishbone was discovered after imaging. The article aims to raise awareness regarding the potential origins of chest pain, highlighting that it may stem from non-cardiac conditions. METHODS:  The methodology employed in this study involved conducting a case study that meticulously examined the repercussions and management strategies associated with foreign body ingestion. RESULTS:  The case report delineates the scenario of a 27-year-old male patient who inadvertently ingested a fishbone during a routine meal. It details the swift decline in clinical status, the meticulous diagnostic procedures employed, the subsequent management strategies implemented and the ultimate discharge of the patient in a stable condition. CONCLUSION:  This case highlights the importance of comprehensive history taking and considering a wide range of causes of chest pain when evaluating a patient. The foreign body ingested with the resulting cardiac complications could have been fatal if not promptly diagnosed.Contribution: This study contributed to advancing awareness surrounding foreign body ingestion, shedding light on potential complications and offering valuable insights into effective management strategies.


Assuntos
Dor no Peito , Esôfago , Corpos Estranhos , Humanos , Masculino , Corpos Estranhos/complicações , Corpos Estranhos/diagnóstico , Corpos Estranhos/diagnóstico por imagem , Adulto , Dor no Peito/etiologia , Esôfago/diagnóstico por imagem , Ingestão de Alimentos
15.
Einstein (Sao Paulo) ; 22: eAO0619, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39258689

RESUMO

OBJECTIVE: Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented by exercise. We evaluated the effects of swimming training on hypothalamic (GLP1-R) and Lep receptor (Lep-R) gene expressions in lactational hypernutrition-induced obesity. METHODS: On the 3rd postnatal day, the litter sizes of lactating dams were adjusted to small litters (SL; 3 pups/dams) or normal litters (NL; 9 pups/dams). After weaning (21 days), NL and SL male rats were randomly distributed to sedentary (Sed) and exercised (Exe) groups. Exercised mice swam (30 min/3 times/week) for 68 days. Food intake and body weight gain were registered. At 92 days, intraperitoneal glucose and insulin tolerance tests were performed and rats were euthanized at 93 days; adipose tissue depots were weighed, and blood counts and plasma biochemical analyses performed. Hypothalamus were isolated to evaluate Lep-R and GLP1-R gene expressions. RESULTS: Small litters sedentary rats presented increased body weight gain, adiposity, insulin sensibility and higher fasting values of glucose and triglycerides, besides higher hypothalamic gene expressions of Lep-R and GLP1-R, compared to NLSed animals. SLExe rats did not develop obesity or metabolic abnormalities and Lep-R and GLP1-R hypothalamic gene expressions were normalized. CONCLUSION: Lactational hypernutrition induces obesity and metabolic dysfunction in adult life, in association with higher hypothalamic expressions of the Lep-R and GLP1-R genes. Exercise prevented obesity and improved metabolic state in SL overnourished rats, and normalized their hypothalamic Lep-R and GLP1-R gene expressions.


Assuntos
Hipotálamo , Obesidade , Condicionamento Físico Animal , Ratos Wistar , Receptores para Leptina , Natação , Animais , Hipotálamo/metabolismo , Obesidade/metabolismo , Obesidade/genética , Obesidade/prevenção & controle , Condicionamento Físico Animal/fisiologia , Condicionamento Físico Animal/métodos , Masculino , Receptores para Leptina/genética , Receptores para Leptina/metabolismo , Feminino , Natação/fisiologia , Tamanho da Ninhada de Vivíparos , Receptor do Peptídeo Semelhante ao Glucagon 1/metabolismo , Receptor do Peptídeo Semelhante ao Glucagon 1/genética , Ratos , Lactação/metabolismo , Lactação/fisiologia , Peptídeo 1 Semelhante ao Glucagon/metabolismo , Leptina/sangue , Leptina/metabolismo , Distribuição Aleatória , Expressão Gênica , Ingestão de Alimentos/fisiologia , Adiposidade/fisiologia
16.
Behav Brain Res ; 474: 115201, 2024 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-39151649

RESUMO

OBJECTIVES: Transcranial direct stimulation (tDCS) targeted to the dorsolateral prefrontal cortex (DLPFC) reduces food intake and hunger, but its effects on circulating factors are unclear. We assessed the effect of repeated administration of tDCS to the left DLPFC (L-DLPFC) on concentrations of pro/anti-inflammatory and appetitive hormone concentrations. MATERIALS AND METHODS: Twenty-nine healthy adults with obesity (12 M; 42±11 y; BMI=39±8 kg/m2) received 3 consecutive inpatient sessions of either anodal or sham tDCS targeted to the L-DLPFC during a period of ad libitum food intake. Fasting plasma concentrations of IL-6, orexin, cortisol, TNF-α, IL-1ß, ghrelin, PYY, and GLP-1 were measured before the initial and after the final tDCS sessions. RESULTS: IL-6 (ß=-0.92 pg/ml p=0.03) decreased in the anodal group compared with sham, even after adjusting for kcal intake; there were no changes in other hormones. Mean kcal intake was associated with higher IL-1ß and ghrelin concentrations after the ad libitum period (ß=0.00018 pg/ml/kcal, p=0.03; ß=0.00011 pg/ml/kcal, p=0.02; respectively), but not differ by intervention groups. CONCLUSIONS: IL-6 concentrations were reduced following anodal tDCS to the L-DLPFC independent of ad libitum intake. IL-6 concentrations reflect the inflammatory state of adiposity and may affect eating behavior and weight gain. These findings provide evidence of therapeutic benefit of tDCS.


Assuntos
Grelina , Interleucina-6 , Obesidade , Estimulação Transcraniana por Corrente Contínua , Humanos , Masculino , Adulto , Feminino , Interleucina-6/sangue , Grelina/sangue , Obesidade/sangue , Obesidade/terapia , Pessoa de Meia-Idade , Interleucina-1beta/sangue , Hidrocortisona/sangue , Córtex Pré-Frontal Dorsolateral/fisiologia , Córtex Pré-Frontal/metabolismo , Ingestão de Alimentos/fisiologia , Orexinas/sangue , Peptídeo 1 Semelhante ao Glucagon/sangue , Fator de Necrose Tumoral alfa/sangue , Peptídeo YY/sangue
17.
Neuropeptides ; 107: 102464, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39182332

RESUMO

We explored the effect of Ninjinyoeito (NYT) on cisplatin-induced anorexia, which reduces cancer patient survival. Both gastrointestinal motility and plasma concentrations of gastrointestinal peptides were assessed. Nine-week-old ICR female mice received intraperitoneal cisplatin injections (10 mg/kg) and daily oral NYT doses of 300 mg/kg (NYT300) or 1000 mg/kg (NYT1000). Plasma levels of gastrointestinal peptides were measured at 3 and 6 days after cisplatin injection. Gastrointestinal motility was assessed by analyzing the concentration of phenol red marker within sections of the gastrointestinal tract. Cisplatin-injected mice showed a decrease in daily food intake, but this effect was attenuated on day 5 with NYT1000 administration. Although plasma ghrelin levels were reduced on day 3 in cisplatin-treated mice, NYT1000 administration ameliorated this decrease. However, there were no differences in ghrelin levels among all groups on day 6. Levels of peptide YY (PYY) were elevated in the plasma of cisplatin-injected mice on days 3 and 6. Administration of NYT300 and NYT1000 suppressed the increase in PYY levels on day 6 but not on day 3. Gastrointestinal motility was impaired on day 6 in cisplatin-treated mice, but NYT1000 administration attenuated this effect. Our results suggest that NYT improves cisplatin-induced anorexia by suppressing alterations in ghrelin and PYY levels and by increasing gastrointestinal motility. Therefore, NYT may be a promising candidate for alleviating cisplatin-induced anorexia.


Assuntos
Anorexia , Cisplatino , Medicamentos de Ervas Chinesas , Motilidade Gastrointestinal , Grelina , Camundongos Endogâmicos ICR , Peptídeo YY , Animais , Grelina/sangue , Anorexia/induzido quimicamente , Anorexia/tratamento farmacológico , Anorexia/metabolismo , Feminino , Peptídeo YY/sangue , Camundongos , Motilidade Gastrointestinal/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Antineoplásicos , Ingestão de Alimentos/efeitos dos fármacos
18.
Nat Neurosci ; 27(9): 1774-1782, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39107488

RESUMO

Despite the well-known health benefits of physical activity, many people underexercise; what drives the prioritization of exercise over alternative options is unclear. We developed a task that enabled us to study how mice freely and rapidly alternate between wheel running and other voluntary activities, such as eating palatable food. When multiple alternatives were available, mice chose to spend a substantial amount of time wheel running without any extrinsic reward and maintained this behavior even when palatable food was added as an option. Causal manipulations and correlative analyses of appetitive and consummatory processes revealed this preference for wheel running to be instantiated by hypothalamic hypocretin/orexin neurons (HONs). The effect of HON manipulations on wheel running and eating was strongly context-dependent, being the largest in the scenario where both options were available. Overall, these data suggest that HON activity enables an eat-run arbitration that results in choosing exercise over food.


Assuntos
Neurônios , Orexinas , Condicionamento Físico Animal , Animais , Orexinas/metabolismo , Neurônios/fisiologia , Camundongos , Condicionamento Físico Animal/fisiologia , Masculino , Camundongos Endogâmicos C57BL , Hipotálamo/fisiologia , Recompensa , Comportamento Alimentar/fisiologia , Ingestão de Alimentos/fisiologia , Corrida/fisiologia , Atividade Motora/fisiologia
19.
Environ Pollut ; 360: 124659, 2024 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-39097262

RESUMO

The ingestion of debris by marine fauna is a growing threat to biodiversity. This study aimed to evaluate and characterize litter ingestion by odontocetes from the Western South Atlantic. Between 2018 and 2022, 154 stomachs from six species were collected from stranded individuals and incidental captures. Stomach contents were analyzed with the naked eye and items of anthropic origin found were counted and physically/chemically characterized. Generalized Linear Models were used to evaluate the influence of biological factors on the presence/absence of litter in stomachs, and for Pontoporia blainvillei only, the influence of these factors on the number of ingested items was also tested; additionally, a temporal analysis of ingestion was done for this species (1994-2022). A total of 156 items, mainly macro-sized plastics made of polypropylene, were found in 52 stomachs of four species: Tursiops spp. (FO% = 3.3%), Steno bredanensis (10.0%), Delphinus delphis (28.6%) and P. blainvillei (47.5%). The presence/absence of litter was explained only by species (χ2 = 28.29 and p < 0.001). For P. blainvillei, a threatened species in the region, the number of items was positively influenced by individual size (χ2 = 6.01 and p = 0.01) and sex (χ2 = 7.93 and p = 0.005). There was an increase in plastic ingestion by this species over the years (χ2 = 121.6 and p < 0.001) and it was estimated that 75% of P. blainvillei stomachs will contain plastic by 2040. The ingestion of litter by odontocetes from the Western South Atlantic was confirmed and the potential risks posed by this type of pollution were evidenced, especially since these species also face other anthropic pressures. These results further demonstrate the increasing threat of litter in the ocean and highlight the importance of circularity of plastics and proper waste management.


Assuntos
Espécies em Perigo de Extinção , Plásticos , Plásticos/análise , Animais , Monitoramento Ambiental/métodos , Oceano Atlântico , Feminino , Conteúdo Gastrointestinal/química , Masculino , Ingestão de Alimentos , Resíduos/análise
20.
Nutrients ; 16(15)2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-39125278

RESUMO

(1) Background: We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2) Methods: We assessed food intake, gastric retention (GR), and gene expression in all groups. (3) Results: Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4) Conclusions: This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.


Assuntos
Regulação do Apetite , Hipotálamo , Neuropeptídeo Y , Azeite de Oliva , Óleo de Palmeira , Óleo de Soja , Nervo Vago , Animais , Nervo Vago/efeitos dos fármacos , Nervo Vago/fisiologia , Hipotálamo/metabolismo , Hipotálamo/efeitos dos fármacos , Masculino , Azeite de Oliva/farmacologia , Neuropeptídeo Y/genética , Neuropeptídeo Y/metabolismo , Óleo de Palmeira/farmacologia , Regulação do Apetite/efeitos dos fármacos , Óleo de Soja/administração & dosagem , Óleo de Soja/farmacologia , Ratos Wistar , Óleo de Semente do Linho/farmacologia , Ratos , Ingestão de Alimentos/efeitos dos fármacos , Óleos de Plantas/farmacologia , Pró-Opiomelanocortina/genética , Pró-Opiomelanocortina/metabolismo , Proteínas do Tecido Nervoso/genética , Proteínas do Tecido Nervoso/metabolismo , Motilidade Gastrointestinal/efeitos dos fármacos , Regulação da Expressão Gênica/efeitos dos fármacos , RNA Mensageiro/metabolismo , RNA Mensageiro/genética
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