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1.
Pathol Oncol Res ; 29: 1611328, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37621953

RESUMO

Background: Although the expression of tight junction protein claudins (CLDNs) is well known in common histological subtypes of lung cancer, it has not been investigated in rare lung cancers. The aim of our study was to examine the expression of different CLDNs in pulmonary salivary gland tumors. Methods: 35 rare lung cancers including pathologically confirmed 12 adenoid cystic carcinomas (ACCs) and 23 mucoepidermoid carcinomas (MECs) were collected retrospectively. Immunohistochemical (IHC) staining was performed on formalin fixed paraffin embedded (FFPE) tumor tissues, and CLDN1, -2, -3, -4, -5, -7, and -18 protein expressions were analyzed. The levels of immunopositivity were determined with H-score. Certain pathological characteristics of ACC and MEC samples (tumor grade, presence of necrosis, presence of blood vessel infiltration, and degree of lymphoid infiltration) were also analyzed. Results: CLDN overexpression was observed in both tumor types, especially in CLDN2, -7, and -18 IHC. Markedly different patterns of CLDN expression were found for ACC and MEC tumors, especially for CLDN1, -2, -4, and -7, although none of these trends remained significant after correction for multiple testing. Positive correlations between expressions of CLDN2 and -5, CLDN3 and -4, and CLDN5 and -18 were also demonstrated. Tumors of never-smokers presented lower levels of CLDN18 than tumors of current smokers (p-value: 0.003). Conclusion: This is the first study to comprehensively describe the expression of different CLDNs in lung ACC and MEC. Overexpression of certain CLDNs may pave the way for targeted anti-claudin therapy in these rare histological subtypes of lung cancer.


Assuntos
Carcinoma Adenoide Cístico , Claudinas , Neoplasias Pulmonares , Tumor Mucoepidermoide , Estudos Retrospectivos , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Claudinas/análise , Claudinas/genética , Carcinoma Adenoide Cístico/química , Carcinoma Adenoide Cístico/patologia , Tumor Mucoepidermoide/química , Tumor Mucoepidermoide/patologia , Imuno-Histoquímica , Neoplasias Pulmonares/química , Neoplasias Pulmonares/patologia , Transcriptoma
2.
Int J Cancer ; 147(10): 2772-2779, 2020 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-32445192

RESUMO

Direct comparisons of the incidence and survival of cutaneous vs mucocutaneous genital squamous cell carcinomas (SCCs) are lacking even though they may bring important insights. We aimed to compare incidence rates and survival of cutaneous and mucocutaneous genital SCCs head-to-head, using the same source population, cancer registry methodology and statistical methods in a population of predominantly white Caucasian descent. Using data (2007-2015) from the population-based cancer registry of North Rhine-Westphalia, (population of 18 million people), we estimated age-specific and age-standardized (old European standard) incidence rates and age-standardized relative 5-year survival of SCC with the period approach for the period 2012 to 2015. Overall, 83 650 SCC cases were registered. The age-standardized incidence rates (per 100 000 person-years) of cutaneous SCCs were 36.5 (SE 0.17) and 17.0 (SE 0.11) among men and women, respectively, with corresponding rates for mucocutaneous genital skin, 1.3 (SE 0.03) and 4.5 (SE 0.06) for men and women, respectively. In all age groups, incidence rates of mucocutaneous genital SCCs were higher in women than men. Men had higher cutaneous SCC incidence at all nongenital subsites than women, with the exception of the lower extremities. Five-year relative survival was considerably lower for mucocutaneous genital SCCs (men: 71%, women: 75%), especially of the scrotal skin (67%) and labia majora (62%) than for SCC of nongenital skin (men: 93%, women: 97%). Given their relatively high incidence together with a lower survival probability, future studies are warranted to establish therapies for advanced mucocutaneous genital SCC, such as immune checkpoint inhibition.


Assuntos
Carcinoma de Células Escamosas/epidemiologia , Neoplasias dos Genitais Femininos/epidemiologia , Neoplasias dos Genitais Masculinos/epidemiologia , Tumor Mucoepidermoide/epidemiologia , Neoplasias Cutâneas/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Carcinoma de Células Escamosas/mortalidade , Feminino , Neoplasias dos Genitais Femininos/mortalidade , Neoplasias dos Genitais Masculinos/mortalidade , Alemanha/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Tumor Mucoepidermoide/mortalidade , Sistema de Registros , Caracteres Sexuais , Neoplasias Cutâneas/mortalidade , Análise de Sobrevida , Adulto Jovem
3.
J Nucl Med Technol ; 45(2): 116-118, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28408701

RESUMO

This report presents a case of focal uptake in the right parotid gland found on a follow-up whole-body radioiodine scan 1 y after successful ablation of differentiated papillary thyroid carcinoma. After the parotid tumor had been excised, it was proven histopathologically to be a low-grade mucoepidermoid tumor. This case illustrates a 131I focus that was false-positive for thyroid carcinoma. The short period between radioiodine treatment and development of this parotid tumor creates doubt about a causal relationship. Induction of salivary gland tumors by radiation has been reported primarily in the setting of external radiotherapy. In the large volume of thyroid carcinoma patients treated with radioiodine across the world, such an occurrence has been rare.


Assuntos
Carcinoma Papilar/patologia , Radioisótopos do Iodo , Tumor Mucoepidermoide/diagnóstico por imagem , Neoplasias Parotídeas/diagnóstico por imagem , Neoplasias da Glândula Tireoide/patologia , Adolescente , Carcinoma Papilar/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Tumor Mucoepidermoide/secundário , Neoplasias Parotídeas/secundário , Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide/diagnóstico por imagem
4.
Orbit ; 34(4): 220-2, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26121166

RESUMO

We report a case of a 44-year-old man who presented with a left medial canthal mass and epiphora. Imaging was suggestive of a mass continuous with the nasolacrimal sac. Subsequent surgical exploration revealed a mass adherent to bone with invasion of the lacrimal system. Histological examination revealed a squamous/transitional cell papilloma overlying a low-grade mucoepidermoid carcinoma (MEC). Complete surgical resection was completed and pathology confirmed the diagnosis. This is the first case in which a MEC has been reported concurrently with an overlying papilloma, providing support for the hypothesis that MECs arise from papillomas in the lacrimal sac. Additionally, the tissue stained positive for p63, which is congruent with MEC immunoreactivity in the salivary gland. The description of these unique histopathological findings may assist in definitive diagnosis and improve our understanding of the pathophysiology underlying lacrimal sac MEC tumors.


Assuntos
Neoplasias Oculares/cirurgia , Aparelho Lacrimal/cirurgia , Tumor Mucoepidermoide/cirurgia , Papiloma/cirurgia , Adulto , Diagnóstico Diferencial , Neoplasias Oculares/diagnóstico , Humanos , Aparelho Lacrimal/patologia , Masculino , Proteínas de Membrana/análise , Tumor Mucoepidermoide/diagnóstico , Papiloma/diagnóstico , Tomografia Computadorizada por Raios X
5.
Rev Pneumol Clin ; 71(1): 27-36, 2015 Feb.
Artigo em Francês | MEDLINE | ID: mdl-25687822

RESUMO

INTRODUCTION: Mucoepidermoid tumours (TME) are rare tumours arising from the submucosal glands of the tracheobronchial tree. The majority of these tumours develop in a benign fashion but some of them are malignant. The latter can be easily mistaken for adenosquamous carcinomas. PATIENTS AND METHOD: We have reviewed 22 patients suffering from TME observed over a period of 25 years. Two arose from the trachea and 20 from the cartilaginous bronchi; 12 of these tumours had macroscopic and histological criteria of low-grade malignancy, 4 had macroscopic and 6 macroscopic and microscopic criteria of high grade malignancy. RESULTS: Prognosis of the latter was very poor and no survival observed after 6 years follow-up, a behavior similar to that observed in non-small cell lung carcinomas and adenosquamous carcinomas. CONCLUSION: The best treatment of these orphan tumours remains surgery.


Assuntos
Neoplasias Brônquicas , Tumor Mucoepidermoide , Neoplasias da Traqueia , Adulto , Idoso , Neoplasias Brônquicas/epidemiologia , Neoplasias Brônquicas/patologia , Neoplasias Brônquicas/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tumor Mucoepidermoide/epidemiologia , Tumor Mucoepidermoide/patologia , Tumor Mucoepidermoide/cirurgia , Gradação de Tumores , Prognóstico , Procedimentos Cirúrgicos Pulmonares/estatística & dados numéricos , Estudos Retrospectivos , Análise de Sobrevida , Neoplasias da Traqueia/epidemiologia , Neoplasias da Traqueia/patologia , Neoplasias da Traqueia/cirurgia , Adulto Jovem
6.
Turk J Med Sci ; 44(5): 875-82, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25539561

RESUMO

BACKGROUND/AIM: To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics. MATERIALS AND METHODS: A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test. RESULTS: P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, P63, and P73 proteins was not associated with age, sex, or lymph node metastasis (P > 0.05). Expression of P53 and P73 proteins, instead of the P63 protein, was correlated to the degree of malignancy (P = 0.026 and 0.018, respectively). There was no significant difference among the P53, P73, and P63 proteins in malignant parotid gland tumors (P > 0.05). In the follow-up, only one patient died of colon cancer. CONCLUSION: Our results suggest that the P53, P63, and P73 proteins may play a role in the development of malignant parotid gland tumors and provide data for their diagnosis.


Assuntos
Adenocarcinoma/metabolismo , Carcinoma Adenoide Cístico/metabolismo , Proteínas de Ligação a DNA/metabolismo , Tumor Mucoepidermoide/metabolismo , Proteínas Nucleares/metabolismo , Neoplasias Parotídeas/metabolismo , Fatores de Transcrição/metabolismo , Proteínas Supressoras de Tumor/metabolismo , Adulto , Idoso , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Proteína Tumoral p73 , Adulto Jovem
7.
PLoS One ; 9(9): e107712, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25229469

RESUMO

Stem cells contribute to regeneration of tissues and organs. Cells with stem cell-like properties have been identified in tumors from a variety of origins, but to our knowledge there are yet no reports on tumor-related stem cells in the human upper respiratory tract. In the present study, we show that a tracheal mucoepidermoid tumor biopsy obtained from a 6 year-old patient contained a subpopulation of cells with morphology, clonogenicity and surface markers that overlapped with bone marrow mesenchymal stromal cells (BM-MSCs). These cells, designated as MEi (mesenchymal stem cell-like mucoepidermoid tumor) cells, could be differentiated towards mesenchymal lineages both with and without induction, and formed spheroids in vitro. The MEi cells shared several multipotent characteristics with BM-MSCs. However, they displayed differences to BM-MSCs in growth kinectics and gene expression profiles relating to cancer pathways and tube development. Despite this, the MEi cells did not possess in vivo tumor-initiating capacity, as proven by the absence of growth in situ after localized injection in immunocompromised mice. Our results provide an initial characterization of benign tracheal cancer-derived niche cells. We believe that this report could be of importance to further understand tracheal cancer initiation and progression as well as therapeutic development.


Assuntos
Tumor Mucoepidermoide/patologia , Células-Tronco Neoplásicas/patologia , Neoplasias da Traqueia/patologia , Animais , Separação Celular , Criança , Feminino , Perfilação da Expressão Gênica , Genômica , Humanos , Masculino , Células-Tronco Mesenquimais/patologia , Camundongos , Tumor Mucoepidermoide/diagnóstico , Tumor Mucoepidermoide/genética , Neoplasias da Traqueia/diagnóstico , Neoplasias da Traqueia/genética
8.
Proc Natl Acad Sci U S A ; 111(32): E3260-8, 2014 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-25071166

RESUMO

Chimeric oncoproteins created by chromosomal translocations are among the most common genetic mutations associated with tumorigenesis. Malignant mucoepidermoid salivary gland tumors, as well as a growing number of solid epithelial-derived tumors, can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric cAMP response element binding protein (CREB)-regulated transcriptional coactivator 1 (CRTC1)/mastermind-like 2 (MAML2) (C1/M2) oncoprotein comprised of two transcriptional coactivators, the CRTC1 and the NOTCH/RBPJ coactivator MAML2. Accordingly, the C1/M2 oncoprotein induces aberrant expression of CREB and NOTCH target genes. Surprisingly, here we report a gain-of-function activity of the C1/M2 oncoprotein that directs its interactions with myelocytomatosis oncogene (MYC) proteins and the activation of MYC transcription targets, including those involved in cell growth and metabolism, survival, and tumorigenesis. These results were validated in human mucoepidermoid tumor cells that harbor the t (11, 19)(q21;p13.1) translocation and express the C1/M2 oncoprotein. Notably, the C1/M2-MYC interaction is necessary for C1/M2-driven cell transformation, and the C1/M2 transcriptional signature predicts other human malignancies having combined involvement of MYC and CREB. These findings suggest that such gain-of-function properties may also be manifest in other oncoprotein fusions found in human cancer and that agents targeting the C1/M2-MYC interface represent an attractive strategy for the development of effective and safe anticancer therapeutics in tumors harboring the t (11, 19) translocation.


Assuntos
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo , Proteínas de Ligação a DNA/genética , Proteínas de Ligação a DNA/metabolismo , Neoplasias/genética , Neoplasias/metabolismo , Proteínas Nucleares/genética , Proteínas Nucleares/metabolismo , Proteínas de Fusão Oncogênica/genética , Proteínas de Fusão Oncogênica/metabolismo , Proteínas Proto-Oncogênicas c-myc/genética , Proteínas Proto-Oncogênicas c-myc/metabolismo , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismo , Animais , Linhagem Celular , Transformação Celular Neoplásica/genética , Transformação Celular Neoplásica/metabolismo , Cromossomos Humanos Par 1/genética , Cromossomos Humanos Par 19/genética , Proteínas de Ligação a DNA/química , Redes Reguladoras de Genes , Genes myc , Células HEK293 , Humanos , Camundongos , Tumor Mucoepidermoide/genética , Tumor Mucoepidermoide/metabolismo , Células NIH 3T3 , Proteínas Nucleares/química , Proteínas de Fusão Oncogênica/química , Domínios e Motivos de Interação entre Proteínas , Ratos , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/metabolismo , Transativadores , Fatores de Transcrição/química , Translocação Genética
11.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-6

RESUMO

Mucoepidermoid carcinoma is a malignant epithelial tumour of glandular tissue, usually of the major salivary glands. However it can present in the minor salivary glands, especially in the soft palate. We report the case of a 72-year-old Malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid carcinoma of the soft palate.


Assuntos
Tumor Mucoepidermoide , Neoplasias das Glândulas Salivares , Glândulas Salivares Menores
12.
Arq. int. otorrinolaringol. (Impr.) ; 15(1): 99-101, jan.-mar. 2011. ilus
Artigo em Inglês, Português | LILACS | ID: lil-594655

RESUMO

Introdução: Os carcinomas mucoepidermoides (CME) representam cerca de 5% de todos os tumores das glândulas salivares. Trata-se de uma lesão agressiva e deve ser considerada como hipótese de diagnóstico em lesões proliferativas da mucosa oral. O diagnóstico precoce e o correto manejo dessa neoplasia são fatores determinantes do prognóstico. Ressecção local ampla e eventualmente a radioterapia pós-operatória são o tratamento de escolha. Objetivo: Relatar o caso de uma paciente com carcinoma mucoepidermoide de cavidade oral, exteriorando-se pela boca, sendo submetida a exérese cirúrgica e radioterapia, evoluindo para óbito no quarto mês do início do tratamento. Relato do Caso: CT, 47anos, branca, foi encaminhada ao serviço de ORL do HSJA após episódio de sangramento importante em cavidade oral. Relatou o surgimento de uma massa com crescimento rápido e expansivo em topografia de fossa canina há +/- 06 meses, associado a emagrecimento de 10 kg. Paciente desidratada, hipocorada, apresentando tumoração pediculada de +/- 06 cm, consistência firme, indolor à palpação, sangrante. Etilista e tabagista crônica. Linfonodos cervicais não palpáveis. Diante do caso optou por fazer a ressecção cirúrgica do tumor e realizar o exame histopatológico que confirmou carcinoma mucoepidermoide de glândulas salivares menores. A paciente foi encaminhada ao serviço de radioterapia; porém, abandonou o tratamento e evoluiu com óbito 4 meses após. Comentários Finais: Neste caso, o crescimento rápido e agressivo da lesão, o tamanho do tumor e o abandono do tratamento proposto foi determinante no prognóstico da paciente.


Introduction: The Mucoepidermoid Carcinomas (MEC) represent about 5% of all tumors in the salivary glands. It is an aggressive lesion and must be considered as a diagnosis hypothesis in the oral mucosa proliferative lesions. The early diagnosis and the correct management of this neoplasm are key factors for the prognosis. Wide local resection and eventually postoperative radiotherapy is the choice treatment. Objective: To report the case of a patient with mucoepidermoid carcinoma of oral cavity, exteriorizing through the mouth and being submitted to surgical exeresis and radiotherapy that evolved to death on the fourth month from beginning of the treatment. Case Report: CT, 47 years old, white woman was forwarded to the ORL service of the HSJA after a critical bleeding episode in oral cavity. She reported the appearing of a mass with fast and expansive growth in a topography of canine fossa for +/- 06 months, associated to the loss of 10 kg. Patient dehydrated, pale with pediculated tumoration of +/- 06 cm, firm consistency, painless upon palpation and bleeding. Chronic alcoholic and smoker. Non-palpable cervical lymph nodes. Faced with the case we opted for a surgical resection of the tumor and the performance of histopathological exam that confirmed mucoepidermoid carcinoma of minor salivary glands. The patient was sent to the radiotherapy service; but she abandoned the treatment and evolved with death 4 months after. Final Comments: In this case, the fast and aggressive growth of the lesion, the size of the tumor and the abandonment of the proposed treatment was determinant for the patient's prognosis.


Assuntos
Humanos , Feminino , Adulto , Glândulas Salivares Menores/patologia , Tumor Mucoepidermoide/diagnóstico , Tumor Mucoepidermoide/mortalidade , Tumor Mucoepidermoide/radioterapia
14.
Radiographics ; 30(6): 1621-36, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21071379

RESUMO

Various types of tumors can affect the subungual space, including benign solid tumors (glomus tumor, subungual exostosis, soft-tissue chondroma, keratoacanthoma, hemangioma, lobular capillary hemangioma), benign cystic lesions (epidermal and mucoid cysts), and malignant tumors (squamous cell carcinoma, malignant melanoma). Imaging plays an important role in the detection and differentiation of subungual tumors because of their small size, nonspecific clinical manifestations, and functional significance. Ultrasonography (US)-in particular, high-resolution US with color Doppler studies-provides useful information regarding tumor size, location, shape, and internal characteristics (cystic, solid, or mixed), but it is limited in the further characterization of tissue. Magnetic resonance (MR) imaging has an important role in categorizing tumors according to their anatomic location, pathologic origin, and signal characteristics. There is some overlap between the US and MR imaging features of subungual tumors; however, certain features can allow accurate diagnosis and expedite management when correlated with clinical and pathologic findings.


Assuntos
Neoplasias Ósseas/diagnóstico , Tumor Glômico/diagnóstico , Imageamento por Ressonância Magnética/métodos , Doenças da Unha/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico , Ultrassonografia/métodos , Neoplasias Ósseas/diagnóstico por imagem , Condroma/diagnóstico , Condroma/diagnóstico por imagem , Diagnóstico Diferencial , Cisto Epidérmico/diagnóstico , Cisto Epidérmico/diagnóstico por imagem , Dedos , Tumor Glômico/diagnóstico por imagem , Hemangioma/diagnóstico , Hemangioma/diagnóstico por imagem , Humanos , Ceratoacantoma/diagnóstico , Ceratoacantoma/diagnóstico por imagem , Tumor Mucoepidermoide/diagnóstico , Tumor Mucoepidermoide/diagnóstico por imagem , Doenças da Unha/diagnóstico por imagem , Neoplasias de Tecidos Moles/diagnóstico por imagem , Dedos do Pé
15.
BMC Cancer ; 10: 495, 2010 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-20846391

RESUMO

BACKGROUND: Overexpression of sphingosine kinase-1 (SPHK1) has been demonstrated to be associated with the development and progression in various types of human cancers. The current study was to characterize the expression of SPHK1 in salivary gland carcinomas (SGC) and to investigate the association between SPHK1 expression and progression of SGC. METHODS: The expression of SPHK1 was examined in 2 normal salivary gland tissues, 8 SGC tissues of various clinical stages, and 5 pairs of primary SGC and adjacent salivary gland tissues from the same patient, using real-time PCR and western blot analysis. Furthermore, the SPHK1 protein expression was analyzed in 159 clinicopathologically characterized SGC cases by immunohistochemistry. Statistical analyses were performed to determine the prognostic and diagnostic associations. RESULTS: SPHK1 expression was found to be markedly upregulated in SGC tissues than that in the normal salivary gland tissues and paired adjacent salivary gland tissues, at both mRNA and protein levels. Statistical analysis revealed a significant correlation of SPHK1 expression with the clinical stage (P = 0.005), T classification (P = 0.017), N classification (P = 0.009), M classification (P = 0.002), and pathological differentiation (P = 0.013). Patients with higher SPHK1 expression had shorter overall survival time, whereas patients with lower SPHK1 expression had better survival. Importantly, patients in the group without adjuvant therapy who exhibited high SPHK1 expression had significantly lower overall survival rates compared with those with low SPHK1 expression. Moreover, multivariate analysis suggested that SPHK1 expression might be an independent prognostic indicator for the survival of SGC patients. CONCLUSIONS: Our results suggest that SPHK1 expression is associated with SGC progression, and might represent as a novel and valuable predictor for adjuvant therapy to SGC patients.


Assuntos
Biomarcadores Tumorais/metabolismo , Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo , Neoplasias das Glândulas Salivares/metabolismo , Glândulas Salivares/metabolismo , Adenocarcinoma Papilar/genética , Adenocarcinoma Papilar/metabolismo , Adenocarcinoma Papilar/patologia , Biomarcadores Tumorais/genética , Western Blotting , Carcinoma de Células Acinares/genética , Carcinoma de Células Acinares/metabolismo , Carcinoma de Células Acinares/patologia , Carcinoma Adenoide Cístico/genética , Carcinoma Adenoide Cístico/metabolismo , Carcinoma Adenoide Cístico/patologia , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Estudos de Coortes , Progressão da Doença , Feminino , Raios gama , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Tumor Mucoepidermoide/genética , Tumor Mucoepidermoide/metabolismo , Tumor Mucoepidermoide/patologia , Cuidados Paliativos , Fosfotransferases (Aceptor do Grupo Álcool)/genética , Prognóstico , RNA Mensageiro/genética , Radioterapia Adjuvante , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares/patologia , Taxa de Sobrevida
16.
Artigo em Inglês | MEDLINE | ID: mdl-20451836

RESUMO

An oncocytic mucoepidermoid carcinoma arising from the minor salivary gland origin is extremely rare. We report on a 44-year-old man with a high-grade oncocytic mucoepidermoid carcinoma originating in the minor salivary gland of the posterior mandible. All tumor cells showed the expected pattern of immunoreactivity, with positive results for the antimitochondrial antibody and p63, and negative results for the androgenic receptor antibody. Microscopically, the tumor was considered to be a high-grade carcinoma in the grading systems of the Armed Forces Institute of Pathology and Brandwein. The patient underwent a partial mandibulectomy, and the lesion was reconstructed with a right fibula osteofasciocutaneous flap under general anesthesia. The patient is currently under long-term follow-up.


Assuntos
Tumor Mucoepidermoide/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Adulto , Autoanticorpos/metabolismo , Humanos , Imunofenotipagem , Masculino , Proteínas de Membrana/imunologia , Mitocôndrias/imunologia , Tumor Mucoepidermoide/imunologia , Tumor Mucoepidermoide/metabolismo , Tumor Mucoepidermoide/cirurgia , Células Oxífilas/patologia , Neoplasias das Glândulas Salivares/imunologia , Neoplasias das Glândulas Salivares/metabolismo , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares Menores/imunologia , Glândulas Salivares Menores/metabolismo , Glândulas Salivares Menores/cirurgia , Resultado do Tratamento
17.
Urol Int ; 82(1): 122-4, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19172112

RESUMO

The authors present the case of a 52-year-old man who had recurring scrotal abscesses resulting in oncotomy being carried out seven times within 2 years. Eventually, it was dissected out totally. Histology proved anaplastic cancer metastasis. The primary tumor was detected in the bronchia; moreover, metastases were found in other organs as well. The patient died 6 weeks after the first diagnosis. We intended to draw attention to frequently occurring scrotal inflammation and thus the underlying diseases. We emphasize the importance of histology examinations.


Assuntos
Abscesso/patologia , Neoplasias Brônquicas/patologia , Neoplasias dos Genitais Masculinos/secundário , Tumor Mucoepidermoide/secundário , Escroto/patologia , Abscesso/cirurgia , Evolução Fatal , Neoplasias dos Genitais Masculinos/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Recidiva , Escroto/cirurgia , Tomografia Computadorizada por Raios X , Procedimentos Cirúrgicos Urológicos Masculinos
19.
An. otorrinolaringol. Ibero-Am ; 34(3): 257-271, mayo-jun. 2007. ilus, tab
Artigo em Es | IBECS | ID: ibc-64600

RESUMO

Analizamos nuestros resultados en el tratamiento de los tumores de la glándula parótida diagnosticados desde 1981 hasta finales del 2004. Vimos 132 pacientes con tumores de la parótida, siendo 41 de ellos malignos. La técnica quirúrgica más usada fue la parotidectomía total con conservación del nervio facial. La supervivencia global que obtuvimos en los tumores malignos fue del 60% a los cinco años. La cirugía es el tratametno de elección de los tumores de estirpe epitelial de la glándula parótida. Los derivados del tejido linfoide deben tratarse por otros medios y son patrimonio de la oncología hematológica


We analyse our results in the treatment of the tumors of the parotid gland, diagnosticated from 1981 till end of 2004. We saw 132 patients with tumors of the parotid, being 41 of them malignant. The surgical technique more used was the total parotidectomy with conservation of the facial nerve. The global survival obtained in the malignant tumors was 60% after five years. Surgery is the treatment of election in the tumors of epitelial origin of the parotid gland. The derived of the lymphoid tissue must be treated by other ways and are inheritance of the hematologic oncology


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Neoplasias Parotídeas/diagnóstico , Neoplasias Parotídeas/tratamento farmacológico , Neoplasias Parotídeas/cirurgia , Estadiamento de Neoplasias/métodos , Seguimentos , Resultado do Tratamento , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Terapia Combinada/métodos , Neoplasias Parotídeas/mortalidade , Neoplasias Parotídeas/radioterapia , Fatores de Tempo , Estudos Retrospectivos , Complicações Pós-Operatórias , Adenolinfoma/patologia , Lipossarcoma/patologia , Tumor Mucoepidermoide/complicações , Tumor Mucoepidermoide/patologia , Tumor Mucoepidermoide/cirurgia
20.
An. otorrinolaringol. Ibero-Am ; 34(2): 195-200, mar.-abr. 2007. ilus
Artigo em Es | IBECS | ID: ibc-053620

RESUMO

Aunque los linfomas son una enfermedad con afectación típica de los ganglios linfáticos pueden presentarse en otras localizaciones (extranodales). El tejido linfoide de las glándulas salivares puede considerarse parte del denominado tejido linfoide asociado a mucosas (MALT). Presentamos un caso de linfoma parotideo difuso de células B grandes. La localización en la parótida, dentro de su rareza, es la más común para los linfomas de glándulas salivares cuyo diagnóstico definitivo es siempre anatomopatológico examinando la pieza extirpada ya que la biopsia puede noser suficiente y conducir a un diagnóstico erróneo aparte de un riesgo mayor de lesión del nervio facial


Although lymphomas are an illness that characteristically affects te lymph nodes they can present in other locations (extranodes). The lymphoid tissue of the salivary glands can be considered part of the called mucosa-associated lymphoid tissue (MALT). We report the case of a diffuse large B-cells parotid lymphoma. The location on the parotid gland, within its rareness, is the most common for salivar gland lymphomas whose diagnosis is always histological by examination of the removed piece since the biopsy can be nonsufficient and take to a wrong diagnosis besides the greater risk on injury on the facial nerve


Assuntos
Masculino , Idoso , Humanos , Linfoma de Zona Marginal Tipo Células B/patologia , Neoplasias Parotídeas/patologia , Linfoma Difuso de Grandes Células B/patologia , Tumor Mucoepidermoide/patologia , Carcinoma Adenoide Cístico/patologia , Carcinoma de Células Acinares/patologia
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