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1.
Acta Odontol Scand ; 83: 493-499, 2024 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-39267359

RESUMO

PURPOSE: To investigate the correlation between the marginal bone height of implants in the posterior maxilla of patients with periodontal disease and the inclination of cusp, providing a theoretical basis for the occlusal design of implant restorations in such patients.  Methods: A total of 80 patients with periodontal disease who underwent implant restoration in the posterior maxilla (55 men and 25 women; mean age 56.66 ± 12.70 years) were selected, with a total of 80 implant restorations (one implant restoration per patient). In addition to recording the main research factor of the inclination of cusp, general patient information, implant characteristics and restoration characteristics were taken, and retrospective analysis of the case data and imaging data of the 80 patients from over 3 years was conducted. Cone beam computed tomography was performed preoperatively and 3 years after implant loading to measure and calculate the marginal bone height of the implants using the One Volume Viewer software. Correlation analysis was performed to determine the relationship between the inclination of the cusp and marginal bone height.  Results: There was a positive correlation between the inclination of cusp and the marginal bone height of the implants, with a correlation coefficient of 0.661 (p < 0.001); the diameter of the implants, implant type and restoration type were negatively correlated with the marginal bone height of the implants, with correlation coefficients of -0.364 (p = 0.001), -0.232 (p = 0.038) and -0.298 (p = 0.007), respectively.  Conclusion: When designing the occlusion of implant restorations in the posterior maxilla of patients with periodontal disease, it is advisable to appropriately reduce the restoration's inclination of cusp.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Doenças Periodontais , Humanos , Estudos Retrospectivos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Adulto , Implantes Dentários , Maxila/cirurgia , Maxila/diagnóstico por imagem
2.
Compend Contin Educ Dent ; 45(8): 396-402, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39276787

RESUMO

Chronic kidney disease (CKD) refers to any abnormalities in kidney structure or function that remain longer than 3 months and negatively impact health. Characterized by a loss of nephrons and a decline in the glomerular filtration rate, CKD can stem from various diseases, such as glomerular, vascular, and others, with treatment options including dialysis or kidney transplantation. Many patients with CKD go undetected because they exhibit no symptoms. Periodontal disease is an inflammatory reaction that results in destruction in the periodontium's connective tissues and alveolar bone, potentially leading to such clinical signs and symptoms as edema, erythema, bleeding on probing, suppuration, tooth mobility and migration, alveolar bone loss, and tooth loss. Recent studies point to a connection between periodontal disease and systemic conditions, including CKD. Periodontal disease severity and presence may correlate with the occurrence of CKD. While various bacteria can cause periodontal disease, specific ones, such as Gram-negative bacilli, are linked to the beginning and progression of CKD, especially in people with compromised immune systems. It is beneficial, therefore, for clinicians to understand the association between CKD and periodontal disease.


Assuntos
Doenças Periodontais , Insuficiência Renal Crônica , Humanos , Insuficiência Renal Crônica/complicações , Doenças Periodontais/complicações , Taxa de Filtração Glomerular
3.
Compend Contin Educ Dent ; 45(8): 428-429, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39276792

RESUMO

Nutrition has been recognized as a foundation for good oral health and general health, with a bidirectional relationship having been established between nutrition and oral and overall health.1 Various specific macro- and micronutrients from the intake of food serve as fuel for a person's body to grow and function.1 The oral cavity plays the unique role of gatekeeper, providing the pathway of nutrition to the body. Because of the rapid cell turnover of oral mucosa, the oral cavity also may manifest early signs of nutrient deficiencies as well as other indicators of systemic disease.2 As a result, problems in the oral cavity can profoundly affect one's appetite, desire and ability to eat, and, consequently, nutritional status and overall health.1.


Assuntos
Estado Nutricional , Doenças Periodontais , Humanos , Saúde Bucal
4.
J Clin Pediatr Dent ; 48(5): 86-94, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39275824

RESUMO

To comparatively assess the periodontal condition and oral hygiene of children and adolescents at different ages presenting with different types of orofacial clefts (OFCs). A total of 1608 patients aged 6-18 years who had not previously undergone periodontal treatment were enrolled in this study. Participants were categorized into two age groups: 6-12 years (Group I) and 13-18 years (Group II). Participants in both age groups were further classified into one of the three OFC-type subgroups: cleft lip only (without or with alveolar cleft), cleft lip and cleft palate, and cleft palate only. Periodontal health was determined by evaluating plaque formation and gingival status with reference to the Silness and Loe plaque index (PI), Loe gingival index (GI), and community periodontal index (CPI). Periodontal health and oral hygiene were not significantly different between Groups I and II for cleft type (p > 0.05). A significant difference was not observed in PI for cleft type among the groups (p > 0.05). In Group II, GI and CPI were significantly higher than in Group I (p < 0.05). According to our results, cleft type does not influence periodontal health of children and adolescents with OFCs. Age, however, influences periodontal diseases' prevalence and severity.


Assuntos
Fenda Labial , Fissura Palatina , Índice de Placa Dentária , Higiene Bucal , Doenças Periodontais , Índice Periodontal , Humanos , Fenda Labial/complicações , Fissura Palatina/complicações , Adolescente , Criança , Masculino , China/epidemiologia , Feminino , Fatores Etários , Placa Dentária
5.
Clin Oral Investig ; 28(10): 521, 2024 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-39264471

RESUMO

OBJECTIVES: In this review, we explored potential associations between NO and its derivatives, nitrite and nitrate, with periodontal and cardiovascular diseases, with special emphasis on the former. By providing a state-of-the-art and integrative understanding of this topic, we aimed to shed light on the potential role of these three nitrogen oxides in the periodontitis-hypertension nexus, identify knowledge gaps, and point out critical aspects of the experimental methodologies. MATERIALS AND METHODS: A comprehensive literature review was conducted on human salivary and plasma concentrations of nitrate and nitrite, and their impact on periodontal and cardiovascular health. RESULTS: A nitrate-rich diet increases nitrate and nitrite levels in saliva and plasma, promoting oral health by favorably altering the oral microbiome. Chlorhexidine (CHX) mouthrinses disrupt the nitrate-nitrite-NO pathway, reducing NO bioavailability, and potentially affecting blood pressure. This is because CHX eliminates nitrate-reducing bacteria, which are essential for NO production. Although endogenous NO production may be insufficient, the nitrate-nitrite-NO pathway plays a critical role in maintaining appropriate endothelial function, which is balanced by the microbiome and dietary nitrate intake. Dietary nitrate supplementation may lead to beneficial changes in the oral microbiome, thereby increasing the NO bioavailability. However, NO bioavailability can be compromised by reactive oxygen species (ROS) and the uncoupling of endothelial nitric oxide synthase (eNOS), leading to further ROS generation and creating a detrimental cycle. Studies on NO and periodontal disease have shown increased nitrite concentrations in patients with periodontal disease, although these studies have some methodological limitations. In terms of blood pressure, literature suggests that CHX mouthrinses may reduce the capacity of nitrate-reducing bacteria, potentially leading to an increase in blood pressure. CONCLUSIONS: Several studies have suggested an association between NO levels and the development of cardiovascular and periodontal diseases. However, the exact mechanisms linking these diseases remains to be fully elucidated. CLINICAL RELEVANCE: Nitric oxide (NO) is a signaling molecule that plays a crucial role in several physiological processes such as vascular homeostasis, inflammation, immune cell activity, and pathologies such as hypertension and periodontitis.


Assuntos
Nitratos , Óxido Nítrico , Doenças Periodontais , Humanos , Óxido Nítrico/metabolismo , Pressão Sanguínea , Nitritos , Hipertensão , Saliva/metabolismo , Saliva/química , Saliva/microbiologia , Doenças Cardiovasculares
6.
BMC Oral Health ; 24(1): 1066, 2024 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-39261859

RESUMO

BACKGROUND: Patients undergoing haemodialysis are more susceptible to infectious diseases, including periodontitis. This study aimed to investigate the Correlation between periodontal disease and serum markers in Yemeni haemodialysis patients. METHODS: A cross-sectional study was conducted on a sample of 70 haemodialysis patients. Patient interviews, clinical examinations, and laboratory tests were performed to collect data. Serum levels of albumin, calcium, phosphorus, haemoglobin, ferritin, and creatinine were measured, with separate measurements for cystatin C The association between categorical variables was assessed using the chi-square test and Pearson's correlation coefficient, considering a significance level of p < 0.05. RESULTS: Significant correlations were found between serum biomarkers and periodontal clinical parameters. Phosphorus, creatinine, albumin, ferritin, and creatinine levels correlated significantly with the Plaque Index (p < 0.001, p < 0.001, p = 0.015, p = 0.018, and p = 0.03). While the Ferritin level showed significant correlations with both the Plaque Index and Miller Classes (r = 0.281, p = 0.018 and r = 0.258, p = 0.031), respectively. The Calcium level showed a significant correlation with the Gingival Index (r = 0.266, p = 0.027). Cystatin C level was statistically correlated with mobility (r = 0.258, p = 0.031). Also, the result showed a significant correlation between Creatinine levels and Periodontitis (r = 0.26, p = 0.03). CONCLUSION: This study provides evidence of a strong association between periodontal disease and chronic kidney disease in Yemeni haemodialysis patients. The findings emphasize the significance of maintaining good oral health in the care of haemodialysis patients.


Assuntos
Biomarcadores , Cálcio , Creatinina , Cistatina C , Ferritinas , Doenças Periodontais , Fósforo , Diálise Renal , Humanos , Biomarcadores/sangue , Masculino , Feminino , Estudos Transversais , Pessoa de Meia-Idade , Ferritinas/sangue , Creatinina/sangue , Cistatina C/sangue , Fósforo/sangue , Cálcio/sangue , Doenças Periodontais/sangue , Adulto , Idoso , Hemoglobinas/análise , Índice Periodontal , Índice de Placa Dentária , Albumina Sérica/análise
7.
Front Immunol ; 15: 1438726, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39221238

RESUMO

Mechanical forces affect periodontal health through multiple mechanisms. Normally, mechanical forces can boost soft and hard tissue metabolism. However, excessive forces may damage the periodontium or result in irreversible inflammation, whereas absence of occlusion forces also leads to tissue atrophy and bone resorption. We systemically searched the PubMed and Web of Science databases and found certain mechanisms of mechanical forces on immune defence, extracellular matrix (ECM) metabolism, specific proteins, bone metabolism, characteristic periodontal ligament stem cells (PDLSCs) and non-coding RNAs (ncRNAs) as these factors contribute to periodontal homeostasis. The immune defence functions change under forces; genes, signalling pathways and proteinases are altered under forces to regulate ECM metabolism; several specific proteins are separately discussed due to their important functions in mechanotransduction and tissue metabolism. Functions of osteocytes, osteoblasts, and osteoclasts are activated to maintain bone homeostasis. Additionally, ncRNAs have the potential to influence gene expression and thereby, modify tissue metabolism. This review summarizes all these mechanisms of mechanical forces on periodontal homeostasis. Identifying the underlying causes, this review provides a new perspective of the mechanisms of force on periodontal health and guides for some new research directions of periodontal homeostasis.


Assuntos
Homeostase , Mecanotransdução Celular , Ligamento Periodontal , Periodonto , Humanos , Periodonto/metabolismo , Animais , Ligamento Periodontal/metabolismo , Matriz Extracelular/metabolismo , Estresse Mecânico , Doenças Periodontais/metabolismo , Doenças Periodontais/imunologia , RNA não Traduzido/genética , RNA não Traduzido/metabolismo , Células-Tronco/metabolismo
8.
Ned Tijdschr Tandheelkd ; 131(9): 359-362, 2024 Sep.
Artigo em Holandês | MEDLINE | ID: mdl-39250685

RESUMO

Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. In addition to bowel symptoms, patients may also have oral manifestations. This thesis investigated potential associations between disease activity in the gut, oral health, salivary gland function, and saliva composition. Patients with Crohn's disease had a significantly higher DMFT index, but showed no difference in periodontal diseases compared to a healthy control group. The saliva composition in patients with active bowel disease differed from that in patients with inactive bowel disease, suggesting that saliva analysis could potentially be used in the future to determine the degree and severity of bowel disease. The knowledge of gastroenterologists and dentists regarding oral manifestations of bowel diseases was found to be limited. Gastroenterologists and dentists valued interdisciplinary patient consultation as very useful, but the frequency of consultation was considered insufficient.


Assuntos
Saúde Bucal , Humanos , Saliva/química , Saliva/metabolismo , Doenças Inflamatórias Intestinais/complicações , Doença de Crohn/complicações , Doenças da Boca/etiologia , Doenças Periodontais/etiologia , Colite Ulcerativa/complicações , Glândulas Salivares
9.
Biomedica ; 44(3): 355-367, 2024 08 29.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-39241238

RESUMO

Introducción. El parto prematuro es un problema médico, social y económico importante, causa gran mortalidad y morbilidad neonatal, tiene un impacto importante en el sistema de salud y afecta la calidad de vida de las familias. El peso de los recién nacidos de madres con enfermedad periodontal es significativamente menor en comparación con los de madres no afectadas por esta enfermedad bucal. Este resultado adverso se considera un problema de salud pública global según los datos epidemiológicos. Objetivo. Determinar la asociación entre la prevalencia de parto prematuro y la enfermedad periodontal en Bolivia, Chile y Colombia entre el 2000 y el 2020. Materiales y métodos. Este estudio ecológico consideró las poblaciones de mujeres de Bolivia, Chile y Colombia, y la prevalencia de partos prematuros y enfermedad periodontal, discriminadas por grupos de edad. El estudio abarcó el período entre el 2000 y el 2020. La estrategia de búsqueda con la herramienta de investigación del Institute for Health Metrics and Evaluation incluyó prevalencia, grupos de edad, años entre 2000 y 2020, causas de parto prematuro y enfermedad periodontal, contexto y ubicaciones, mujeres y tasas. El análisis estadístico incluyó una regresión lineal simple entre parto prematuro y enfermedad periodontal para cada grupo de edad dentro de cada país. Resultados. Las tasas de partos prematuros fueron mayores en el grupo de 15 a 19 años (Bolivia: 697.563, Chile: 844.864, Colombia: 804.126). La prevalencia de la enfermedad periodontal aumentó con la edad, particularmente en el grupo de 45 a 49 años (Bolivia: 22'077.854, Chile: 34'297.901, Colombia: 32'032,830). Según los grupos de edad, la regresión lineal fue estadísticamente significativa (p < 0,001) para todos los grupos evaluados de la población boliviana, en los grupos mayores de 30 años para las colombianas y solo en el grupo de 15 a 19 años para las mujeres chilenas. Conclusión. Se encontró asociación entre el parto prematuro y la enfermedad periodontal en todos los grupos de edad en Bolivia, solo en el grupo de 15 a 19 años en Chile, y de 30 años y más en Colombia en el período evaluado de 20 años.


Introducción. El parto prematuro es un problema médico, social y económico importante, causa gran mortalidad y morbilidad neonatal, tiene un impacto importante en el sistema de salud y afecta la calidad de vida de las familias. El peso de los recién nacidos de madres con enfermedad periodontal es significativamente menor en comparación con los de madres no afectadas por esta enfermedad bucal. Este resultado adverso se considera un problema de salud pública global según los datos epidemiológicos. Objetivo. Determinar la asociación entre la prevalencia de parto prematuro y la enfermedad periodontal en Bolivia, Chile y Colombia entre el 2000 y el 2020. Materiales y métodos. Este estudio ecológico consideró las poblaciones de mujeres de Bolivia, Chile y Colombia, y la prevalencia de partos prematuros y enfermedad periodontal, discriminadas por grupos de edad. El estudio abarcó el período entre el 2000 y el 2020. La estrategia de búsqueda con la herramienta de investigación del Institute for Health Metrics and Evaluation incluyó prevalencia, grupos de edad, años entre 2000 y 2020, causas de parto prematuro y enfermedad periodontal, contexto y ubicaciones, mujeres y tasas. El análisis estadístico incluyó una regresión lineal simple entre parto prematuro y enfermedad periodontal para cada grupo de edad dentro de cada país. Resultados. Las tasas de partos prematuros fueron mayores en el grupo de 15 a 19 años (Bolivia: 697.563, Chile: 844.864, Colombia: 804.126). La prevalencia de la enfermedad periodontal aumentó con la edad, particularmente en el grupo de 45 a 49 años (Bolivia: 22'077.854, Chile: 34'297.901, Colombia: 32'032,830). Según los grupos de edad, la regresión lineal fue estadísticamente significativa (p < 0,001) para todos los grupos evaluados de la población boliviana, en los grupos mayores de 30 años para las colombianas y solo en el grupo de 15 a 19 años para las mujeres chilenas. Conclusión. Se encontró asociación entre el parto prematuro y la enfermedad periodontal en todos los grupos de edad en Bolivia, solo en el grupo de 15 a 19 años en Chile, y de 30 años y más en Colombia en el período evaluado de 20 años.


Assuntos
Doenças Periodontais , Nascimento Prematuro , Humanos , Chile/epidemiologia , Colômbia/epidemiologia , Bolívia/epidemiologia , Nascimento Prematuro/epidemiologia , Doenças Periodontais/epidemiologia , Feminino , Adulto , Adolescente , Adulto Jovem , Prevalência , Pessoa de Meia-Idade , Gravidez , Recém-Nascido
10.
Dent Clin North Am ; 68(4): 603-617, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39244246

RESUMO

This study gives an insight into certain systemic conditions and factors such as nutrition, age, hematological disorders, hypertension, smoking, obesity, and metabolic syndrome that have a notable effect on the periodontium. The review highlights the importance of taking these factors into consideration in periodontal therapy and their impact on the prognosis of periodontal therapies. The other systemic factors are discussed in detail elsewhere in the special issue.


Assuntos
Hipertensão , Síndrome Metabólica , Obesidade , Doenças Periodontais , Humanos , Prognóstico , Doenças Periodontais/terapia , Obesidade/complicações , Fumar/efeitos adversos , Fatores Etários , Fatores de Risco , Estado Nutricional
11.
Dent Clin North Am ; 68(4): 571-602, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39244245

RESUMO

This review delves into the effects of autoimmune conditions like rheumatoid arthritis, inflammatory disorders such as irritable bowel syndrome, cardiovascular disease, diabetes, infectious ailments like human immunodeficiency virus, and their medications on periodontal therapy outcomes. It also explores the influence of hormones. Understanding these systemic factors is crucial for optimizing periodontal health and treatment efficacy. The review underscores the necessity of considering these variables in periodontal care. Other vital systemic factors are addressed elsewhere in this special edition.


Assuntos
Doenças Periodontais , Humanos , Doenças Periodontais/terapia , Prognóstico , Doenças Cardiovasculares , Resultado do Tratamento , Artrite Reumatoide , Síndrome do Intestino Irritável/terapia , Doenças Autoimunes , Infecções por HIV/complicações , Diabetes Mellitus , Fatores de Risco
12.
Dent Clin North Am ; 68(4): 659-692, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39244250

RESUMO

Genetics plays a significant role in determining an individual's susceptibility to dental diseases, the response to dental treatments, and the overall prognosis of dental interventions. Here, the authors explore the various genetic factors affecting the prognosis of dental treatments focusing on dental caries, orthodontic treatment, oral cancer, prosthodontic treatment, periodontal disease, developmental disorders, pharmacogenetics, and genetic predisposition to faster wound healing. Understanding the genetic underpinnings of dental health can help personalize treatment plans, predict outcomes, and improve the overall quality of dental care.


Assuntos
Doenças Periodontais , Humanos , Prognóstico , Doenças Periodontais/genética , Doenças Periodontais/terapia , Predisposição Genética para Doença , Cárie Dentária/genética , Cárie Dentária/terapia , Neoplasias Bucais/genética , Neoplasias Bucais/terapia , Farmacogenética
13.
BMC Oral Health ; 24(1): 1037, 2024 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-39232693

RESUMO

BACKGROUND: Palatal groove represents a relatively uncommon developmental root anomaly, usually found on the palatal aspect of maxillary incisors. While its origin is controversial, its presence predisposes to severe periodontal defects. AIM: This study aimed to provide a systematic review of the literature focusing on the varied diagnostic techniques and treatment modalities for periodontal lesions arising from the presence of palatal groove. Based on the existing evidence and knowledge, the study also provides a comprehensive decisional tree, guiding clinicians in the challenging decision-making process face to a palatal groove. METHODS: The literature search was conducted on Medline and Cochrane databases by two independent reviewers, who also performed the screening and selection process, looking for English written articles reporting on diagnosis and management (all treatment approaches) of periodontal lesion(s) associated with a palatal groove. Based on this literature, a comprehensive decisional tree, including a standardized palatal groove evaluation and tailored treatment approaches, is proposed. Moreover, a clinical case is described to demonstrate the practical application of the developed decisional tree. RESULTS: Over a total of 451 articles initially identified, 34 were selected, describing 40 patients with 40 periodontal lesions associated with palatal grooves. The case report illustrates a deep, large, circumferential intra-bony defect on the palatal side of the tooth #22 associated with a shallow, moderately long palatal groove in an 18-year-old male patient. Following reevaluation, a single flap surgery was deemed necessary, combined with a regenerative procedure. At 2 years post-treatment, the tooth #22 is healthy, in a functional and esthetic position. The decision-making process, based on local and systemic patient's conditions, should allow an early and precise diagnosis to prevent further complications and undertake an adequate treatment. CONCLUSION: Palatal grooves are relatively rare; however, they are frequently associated with severe periodontal defects. The identification, diagnosis, prompt, and tailored management of the associated lesion is essential to mitigate potential periodontal and endodontic complications related to the presence of palatal groove. SYSTEMATIC REVIEW REGISTRATION: [ https://www.crd.york.ac.uk/prospero/ ], identifier [C CRD42022363194].


Assuntos
Árvores de Decisões , Doenças Periodontais , Humanos , Doenças Periodontais/complicações , Doenças Periodontais/terapia , Raiz Dentária/anormalidades , Raiz Dentária/diagnóstico por imagem , Incisivo/anormalidades , Palato/patologia , Palato/anormalidades
14.
Periodontol 2000 ; 95(1): 102-128, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-39234949

RESUMO

Following a comprehensive patient examination, including the assessment of periodontal and peri-implant diseases as well as considering the patient's needs, a pretherapeutic prognosis for each tooth and implant is given. Teeth and implants with a secure pretherapeutic prognosis require simple procedures and may be regarded as secure abutments for function and with a doubtful pretherapeutic prognosis usually need a comprehensive therapy. Such teeth and implants must be brought into the category with a secure prognosis by means of additional therapy such as endodontic, restorative, and surgical procedures. Teeth and implants with a hopeless pretherapeutic prognosis should be extracted/explanted during the initial phase of cause-related therapy (i.e., infection control). For example, teeth with vertical root fracture or unrestorable caries and implants with mobility or unrestorable malposition fall into the category of hopeless units. The primary goal of periodontal and peri-implant therapy should be to arrest disease progression. The latest consensus statement highlights that periodontitis can be successfully controlled and treated teeth can be retained for life. Nevertheless, for patients with uncontrolled contributing factors, the endpoints might not always be achievable, and low disease activity may be an acceptable therapeutic goal. Similarly, the management of peri-implantitis frequently requires surgical intervention following nonsurgical therapy due to incomplete treatment outcomes. Different surgical modalities can be effective and lead to significant improvement; however, achieving complete resolution of peri-implantitis is challenging, not always predictable, and can depend on multiple baseline factors. Therefore, this review aims at summarising available evidence on the rationale for incorporating systemic, lifestyle-related, clinical, and radiographic prognostic factors into treatment planning of patients diagnosed with periodontal and peri-implant diseases.


Assuntos
Implantes Dentários , Planejamento de Assistência ao Paciente , Humanos , Prognóstico , Doenças Periodontais/terapia , Peri-Implantite/terapia , Progressão da Doença
15.
Proc Natl Acad Sci U S A ; 121(36): e2400528121, 2024 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-39186644

RESUMO

Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue damage. Depending on the anatomic setting, a chronic inflammatory disease can exert unique local and systemic influences, which provide an exceptional opportunity for understanding disease mechanism and testing therapeutic interventions. The oral cavity is an easily accessible environment that allows for protective interventions aiming at modulating the immune response to control disease processes driven by a breakdown of host-microbe homeostasis. Periodontal disease (PD) is a prevalent condition in which quantitative and qualitative changes of the oral microbiota (dysbiosis) trigger nonresolving chronic inflammation, progressive bone loss, and ultimately tooth loss. Here, we demonstrate the therapeutic benefit of local sustained delivery of the myeloid-recruiting chemokine (C-C motif) ligand 2 (CCL2) in murine ligature-induced PD using clinically relevant models as a preventive, interventional, or reparative therapy. Local delivery of CCL2 into the periodontium inhibited bone loss and accelerated bone gain that could be ascribed to reduced osteoclasts numbers. CCL2 treatment up-regulated M2-macrophage and downregulated proinflammatory and pro-osteoclastic markers. Furthermore, single-cell ribonucleic acid (RNA) sequencing indicated that CCL2 therapy reversed disease-associated transcriptomic profiles of murine gingival macrophages via inhibiting the triggering receptor expressed on myeloid cells-1 (TREM-1) signaling in classically activated macrophages and inducing protein kinase A (PKA) signaling in infiltrating macrophages. Finally, 16S ribosomal ribonucleic acid (rRNA) sequencing showed mitigation of microbial dysbiosis in the periodontium that correlated with a reduction in microbial load in CCL2-treated mice. This study reveals a novel protective effect of CCL2 local delivery in PD as a model for chronic inflammatory diseases caused by a disturbance in host-microbe homeostasis.


Assuntos
Quimiocina CCL2 , Homeostase , Animais , Camundongos , Quimiocina CCL2/metabolismo , Doenças Periodontais/microbiologia , Doenças Periodontais/imunologia , Doenças Periodontais/terapia , Disbiose/imunologia , Disbiose/microbiologia , Interações entre Hospedeiro e Microrganismos/imunologia , Macrófagos/imunologia , Masculino , Camundongos Endogâmicos C57BL , Osteoclastos/metabolismo , Periodontite/microbiologia , Periodontite/imunologia
16.
BMC Oral Health ; 24(1): 903, 2024 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-39107771

RESUMO

BACKGROUND: Orthodontic treatment requires good oral hygiene for successful completion of treatment. As protocol, patients are usually given instructions for oral hygiene and diet at the start of treatment, however, they are not fully followed. Different methods are employed in order to increase patient compliance including digital means, however, these are not possible in teaching hospitals with high burden of patient care and limited resources. The present study aims to correlate the patient reported behavior with their clinical findings and treatment need. This will enable us to identify potential sources of motivation which will be incorporated in daily practice and enable us to improve methods to enhance patient's behavior. METHOD: A cross-sectional study was conducted in the orthodontic department of a semi-government teaching hospital from August to October 2023 using a modified questionnaire. The clinical examination was done using a Community Periodontal Index for Treatment Need-C (CPITN-C) probe. The diagnosis of presenting clinical conditions and treatment need was done using Community Periodontal Index for Treatment Need (CPITN) and Gingival Bleeding Index (BI). Data collected was analyzed for frequencies and correlation was done using Spearman Correlation Coefficient. P- value ≤ 0.05 was taken as statistically significant. RESULT: The sample size consisted of 110 patients of which 60% were entitled to receive treatment. The predominant age group was 15-20 years (39.1%). Approximately 70% patients were in code 1 for CPITN and GI and in need of oral hygiene instructions. Overall patients' showed good level of awareness, however, they were not compliant in behavior. CONCLUSION: Although patients showed a good level of awareness towards oral hygiene practices, there was a lack of compliance in following them. Patients were more concerned for being affected by dental caries due to poor oral hygiene than its effect on overall treatment outcome.


Assuntos
Higiene Bucal , Humanos , Estudos Transversais , Feminino , Masculino , Adolescente , Doenças Periodontais/terapia , Adulto , Adulto Jovem , Inquéritos e Questionários , Índice Periodontal , Cooperação do Paciente , Ortodontia Corretiva
17.
PLoS One ; 19(8): e0305130, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39110690

RESUMO

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that causes dysfunction of salivation and harmful oral conditions. The association between periodontal disease (PD) and pSS with or without geniquin therapy remains controversial. This study evaluated the association between geniquin therapy and the risk of subsequent development of PD in pSS patients. From Taiwan's National Health Insurance Research Database, we selected a control cohort of 106,818 pSS patients, followed up from 2000 to 2015, matched (1:4) by age and index year with 427,272 non-pSS patients. We also analyzed 15,149 pSS patients receiving geniquin therapy (cohort 1) and 91,669 pSS patients not receiving geniquin therapy (cohort 2). After adjusting for confounding factors, multivariate Cox proportional hazards regression analysis was used to compare the risk of PD over the 15-year follow-up. In the control cohort, 11,941 (11.2%) pSS patients developed PD compared to 39,797 (9.3%) non-pSS patients. In cohorts 1 and 2, 1,914 (12.6%) pSS patients receiving geniquin therapy and 10,027 (10.9%) pSS patients not receiving geniquin therapy developed PD. The adjusted hazard ratio (HR) for subsequent PD in pSS patients was 1.165 (95% confidence interval [CI] = 1.147-1.195, p < 0.001) and in pSS patients receiving geniquin therapy was 1.608 (95% CI = 1.526-1.702, p < 0.001). The adjusted HR for PD treatment was 1.843. Patients diagnosed with pSS showed an increased risk of developing subsequent PD and receiving PD treatment than patients without pSS, while pSS patients receiving geniquin therapy showed even higher risks.


Assuntos
Doenças Periodontais , Síndrome de Sjogren , Humanos , Síndrome de Sjogren/complicações , Síndrome de Sjogren/epidemiologia , Síndrome de Sjogren/tratamento farmacológico , Taiwan/epidemiologia , Feminino , Masculino , Pessoa de Meia-Idade , Adulto , Doenças Periodontais/complicações , Doenças Periodontais/epidemiologia , Estudos de Coortes , Idoso , Fatores de Risco , Modelos de Riscos Proporcionais
19.
Braz Oral Res ; 38: e070, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39109767

RESUMO

This study aimed to assess whether dentists correctly understand the benefit of a dental treatment when it is presented using absolute numbers or relative risk reduction (RRR). This parallel-group randomized controlled trial recruited dentists from 3 postgraduate courses in Rio de Janeiro, Brazil. Participants received, in sequentially numbered sealed opaque envelopes, the description of a hypothetical scenario of the benefit (avoidance of multiple tooth loss) of nonsurgical periodontal treatment without or with antibiotics. Treatment benefit was presented in 2 different formats: absolute numbers or RRR. Dentists were given 10 minutes to read the treatment scenario and answer 5 questions. The final sample for analysis included 101 dentists. When asked to estimate the number of patients out of 100 who would avoid multiple tooth loss without antibiotics, 17 dentists (33%) in the absolute numbers group and 12 (25%) in the RRR group provided the correct response (p = 0.39). Regarding treatment with antibiotics, 26 dentists (50%) in the absolute numbers group and 14 (29%) in the RRR group provided the correct response (p = 0.04). Only 16 dentists (31%) in the absolute numbers group and 12 (25%) in the RRR group gave correct answers for both questions (p = 0.51). Most dentists did not correctly understand the benefit of the treatment, irrespective of the format it was presented. Slightly more dentists correctly understood the benefit of the treatment when it was presented as absolute numbers than as RRR.


Assuntos
Antibacterianos , Odontólogos , Humanos , Odontólogos/estatística & dados numéricos , Odontólogos/psicologia , Feminino , Masculino , Antibacterianos/uso terapêutico , Brasil , Adulto , Estatísticas não Paramétricas , Comportamento de Redução do Risco , Medição de Risco , Pessoa de Meia-Idade , Doenças Periodontais/terapia , Doenças Periodontais/prevenção & controle , Perda de Dente/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Competência Clínica/estatística & dados numéricos
20.
J Clin Periodontol ; 51(9): 1178-1187, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39128863

RESUMO

AIM: The occurrence of periodontal diseases is still to be determined in large samples of major Brazilian cities. This study aimed to assess the periodontal status of adults from Curitiba, Paraná, Brazil, using periodontitis definitions by the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) and the recently published ACES 2018 Classification Framework. MATERIALS AND METHODS: A multi-stage probability sampling technique was applied to draw individuals aged 18 or older. A total of 566 individuals underwent a full-mouth periodontal examination. Periodontitis cases were defined according to the CDC/AAP and the ACES 2018 Classification Framework. Non-periodontitis cases were classified as healthy or gingivitis. The agreement between the two definitions was calculated. RESULTS: Periodontal health was present in 33.6% and 13.8% of individuals, and gingivitis was found in 11.7% and 7.5%, according to CDC/AAP and ACES, respectively. Mild, moderate and severe periodontitis (CDC/AAP) were present in 2.1%, 33.4% and 19.1% of individuals, respectively. Using ACES, 34.3% had Stages I/II and 43.3% had Stages III/IV. The occurrence of periodontitis was higher when a subgroup of individuals aged 30+ were analysed, ranging from 69.6% (CDC/AAP) to 90.1% (ACES). CDC/AAP and ACES agreement for health, gingivitis and periodontitis accounted for 68.8% of the observations. CONCLUSIONS: Periodontal diseases affect more than 66% of the population aged 18+ years. Classic definition by the CDC/AAP and the recently published ACES Framework yielded moderate agreement.


Assuntos
Doenças Periodontais , Humanos , Brasil/epidemiologia , Adulto , Estudos Transversais , Masculino , Feminino , Pessoa de Meia-Idade , Adolescente , Adulto Jovem , Doenças Periodontais/classificação , Doenças Periodontais/epidemiologia , Idoso , Gengivite/classificação , Gengivite/epidemiologia , Periodontite/classificação , Periodontite/epidemiologia
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