A Novel Prognostic Model Predicts Outcomes in Non-Metastatic Nasopharyngeal Carcinoma Based on Inflammation, Nutrition, and Coagulation Signature.

Purpose: This study aimed to assess the prognostic and predictive value of a circulating hematological signature (CHS) and to develop a CHS-based nomogram for predicting prognosis and guiding individualized chemotherapy in non-metastatic nasopharyngeal carcinoma (NPC) patients. Patients and Methods: NPC patients were recruited between January 2014 and December 2017 at the Jiangxi Cancer Hospital. The CHS was constructed based on a series of hematological indicators. The nomogram was developed by CHS and clinical factors. Results: A total of 779 patients were included. Three biomarkers were selected by least absolute shrinkage and selection operator regression, including prognostic nutritional index, albumin-to-fibrinogen ratio, and prealbumin-to-fibrinogen ratio, were used to construct the CHS. The patients in the low-CHS group had better 5-year DMFS and OS than those in the high-CHS group in the training (DMFS: 85.0% vs 56.6%, p<0.001; OS: 90.3% vs 65.4%, p<0.001) and validation cohorts (DMFS: 92.3% vs 43.6%, p<0.001; OS: 92.1% vs 65.5%, p<0.001). The nomogram_CHS showed better performance than clinical stage in predicting distant metastasis (concordance index: 0.728 vs 0.646). In the low-TRS (total risk scores) group, the patients received RT alone, CCRT and IC plus CCRT had similar 5-year DMFS and OS (p>0.05). In the middle-TRS group, the patients received RT alone had worse 5-year DMFS (58.7% vs 80.8% vs 90.8%, p=0.002) and OS (75.0% vs 94.1% vs 95.0%, p=0.001) than those received CCRT or IC plus CCRT. In the high-TRS group, the patients received RT alone and CCRT had worse 5-year DMFS (18.6% vs 31.3% vs 81.5%, p<0.001) and OS (26.9% vs 53.2% vs 88.8%, p<0.001) than those received IC plus CCRT. Conclusion: The developed nomogram_CHS had satisfactory prognostic accuracy in NPC patients and may individualize risk estimation to facilitate the identification of suitable IC candidates.

Selective detection of sulfasalazine antibiotic and its controllable photodegradation into 5-aminosalicylic acid by visible-light-responsive metal-organic framework.

The extensive use of sulfasalazine (SSZ) antibiotics has brought potential threats to aquatic ecosystems and human health. Thus, necessary measures for the removal of SSZ must be taken to prevent arbitrary antibiotic exposure to the aquatic environment. However, not all the recent photocatalysts that have been used for the degradation of SSZ could not achieve the controlled release of SSZ and hence are losing their medicinal values. Herein, by utilizing an Eosin Y moiety as an efficient light-harvesting and emission site, an Eosin Y-based visible-light-responsive metal-organic framework has been synthesized and characterized, which exhibits high selectivity for detecting the antibiotic SSZ in water and simulated physiological conditions, with a detection limit of below 1 µM (0.4 µg mL-1). It also represents the first example of a MOF-based photocatalyst for the controllable degradation of SSZ into 5-aminosalicylic acid with excellent catalytic activity and recyclability.

Triphenylamine-containing imine-linked porous organic network for luminescent detection and adsorption of Cr(VI) in water.

In this study, an imine-linked luminescent porous organic network (PON) has been successfully synthesized by the Schiff-base condensation reaction between 1,2-diphenylethylenediamine and tris(4-formylphenyl)amine. It exhibits strong fluorescence in an aqueous dispersion and can be applied as a luminescent probe for Cr(VI) (CrO42- and Cr2O72-) with high selectivity and sensitivity (LOD for Cr2O72- and CrO42- were below 0.35 µM and 0.4 µM, respectively) in a turn-off manner. The possible luminescence sensing mechanism and the adsorption capacity of Cr(VI) are also discussed in detail.

Amino and triazole-containing metal-organic frameworks for highly efficient CO2 fixation.

In this study, a novel porous metal-organic framework (MOF) functionalized with amino and triazole moieties has been synthesized. Attributed to the high affinity to CO2 and unsaturated zinc centers, the MOF exhibits high catalytic activity for the CO2 to epoxide cycloaddition reaction, with a turnover number value of up to 10 000 per cycle, and can be reused at least for 20 cycles.

Metal-organic frameworks containing xanthene dyes for photocatalytic applications.

Metal-organic frameworks (MOFs) have recently emerged as a new type of prospective photocatalytic material due to their characteristics such as tunable structures, pore modification, crystalline nature with eliminated structural defects, unique semiconductor properties, etc. However, most of these systems also suffer from low activity, high cost, and low visible light utilization. Xanthene dyes are eco-friendly organic dyes used in photocatalysis. They possess the advantages of low cost, low toxicity, and high visible light response; so, they can be directly used as building blocks to fabricate MOF materials or as proper cocatalysts to increase the absorbance of irradiation leading to the construction of a reasonable photocatalytic system. Herein, we have summarized the recent developments in the study of MOFs containing xanthene dyes for photocatalytic applications. The paper can be divided into two sections depending on whether the xanthene dyes are coordinated in the MOF structure: (i) MOFs synergized with xanthene dyes for photocatalytic applications and (ii) MOFs with xanthene dyes incorporated within ligand backbones for photocatalytic applications. Moreover, in this paper, the present challenges and future opportunities in this field are also discussed.

Synthesis, structure and photocatalytic property of a novel Zn(II) coordination polymer based on in situ synthetized pyridine-3,4-dicarboxylhydrazidate ligand.

One new pyridine-3,4-dicarboxylhydrazidate-coordinated compound [Zn(pdh)] 1 (pdh = pyridine-3,4-dicarboxylhydrazidate) was obtained under the hydrothermal conditions. Noteworthily, the pdh molecules in the title compound originated from the ligand in situ reaction between organic pyridine-3,4-dicarboxylic acid (pdca) and N2H4·H2O. X-ray single-crystal diffraction analysis revealed that the pdh ligands exhibit a special µ4-bridging mode in compound 1, which link Zn(II) centers into a 2D layered structure. The photocatalysis analysis indicates that it is a potential visible light catalyst. In addition, the solid photoluminescence property of compound 1 was also investigated.