[Evaluation of haemostasis and endothelial dysfunction characteristics in patient with community-acquired pneumonia].

The article deals with a study of hemostasis (D-dimer soluble fibrin-monomer complex, time fibrin self-assemblance, antitrombin III, fibrinogen), endothelial dysfunction (f. Willebrand and activity of plasminogen activators inhibitor type 1) and CRP in 61 patients with CAP in the day of admission and before discharge from hospital 17 patients had a severe pneumonia, 6 people died. The levels of all markers (except AT-3) were increased on admission and were reduced before discharge, but within the normal range to include only FW, CRP and time fibrin self-assemblance. DD, CRP and PAI-1 were dependent on the severity of the CAP, severity of SIRS and extent of the inflammatory process. The risk of severe pneumonia increased with the level of D-dimer in the onset of the disease more than 2.0 mkg mL(-1) (OR = 21.8, 95% CI: 3.09-154.8), with the results of TP-test less than 0.5 (RR = 2.68, 95% CI: 1.23-5.84), with CRP greater than 200 mg l(-1) (OR = 4.6, 95% CI: 1.87-11.45) and PAI-1 activity more than 30 U l(-1) (OR = 2.05, 95% CI: 0.88-4.74). Rg-CAP outcomes best reflect the level of DD, measured prior to discharge patients.

[The aggregation functions of thrombocytes in patients with chronic kidneys disease. The relationship with biochemical and hemostasiologic indicators].

The article considers the results of studying the aggregation function of thrombocytes including indicators of homeostasis system and routine biochemical markers in patients with chronic kidneys disease receiving hemodialysis sessions. It is demonstrated that plasma hemostasis is activated in all patients. The relationship is established between aggregation degree and level of fibrinolitic activity of plasma and concentration of calcium and phosphorus in blood serum.

[Laboratory criteria of systemic inflammatory syndrome by surgical abdominal infections].

Results of treatment of 116 patients with acute appendicitis, cholecystitis pancreatitis and other inflammatory diseases of the abdominal cavity, complicated with peritonitis in 53 cases, are analyzed. The concentrations of interleukine-6 (IL-6), tumor necrosis factor small be, Cyrillic (TNF-6) and its soluble receptor in peripheral blood were used as systemic inflammatory response indicators. The increase of IL-6 and soluble TNF-6 receptor concentrations correlated with the augmentation of inflammatory response. The Willebrand factor with plasma activity of 180-200% can be used as an early indicator of inflammatory response in patients with acute abdominal diseases. The higher activity of the Willebrand factor is associated with multiple organ failure syndrome.

[Epidemiology of pulmonary thromboembolism as evidenced by autopsies].

Among different forms of cardiovascular pathology, there has been recently an increase in the incidence of thromboembolic complications in the pulmonary arterial system. In epidemiology, there are certain problems associated with the scarcity of specific symptoms and diagnostic methods, the insidiousness of deep vein thrombosis and fatal manifestations of pulmonary thromboembolism (PTE). The prevalence of fatal embolism has been more accurately studied when PTE is a major or promoting cause of death.

[The epidemiology of pulmonary embolism, as evidenced by autopsies].

Among different forms of cardiovascular diseases, there is a considerable increase in the incidence of thromboembolic complications in the pulmonary arterial system. In the assessment of epidemiology, there are certain problems associated with the paucity of specific symptoms and diagnostic techniques, the perfidy of the course, appeared as asymptomatic deep vein thrombosis and fatal manifestations of pulmonary thromboembolism. The prevalence of fatal embolism has been adequately studied when pulmonary thromboembolism is a major or contributory cause of death.

[Place of antithrombin III concentrate in the intensive care of disseminated intravascular coagulation].

The paper presents provisional data on the use of antithrombin III concentrate in the therapy of disseminated intravascular coagulation. Correction of insufficient antithrombin III activity in the complex therapy of thrombinemia and multiple organ dysfunctions is pathogenetically substantiated.

[Role of genetic polymorphisms of the hemostatic system in the development of multiple organ dysfunctions in acute disseminated intravascular coagulation].

The paper deals with the hereditary predisposition of the hemostatic system to the severe course of acute disseminated intravascular coagulation (DIC). The results of evaluation of some types of genetic polymorphisms of the factors of coagulation and of the fibrinolytic system are recent and important for clinical application. Analysis of mortality in the fulminant course of acute DIC showed significant differences in the detection rates of the variants of genetic polymorphism in the type I plasminogen activator inhibitor gene, which is indicative of the possible genetic determination of acute DIC.

[Optimization of intensive care of acute disseminated intravascular syndrome]. / K voprosu ob optimizatsii intensivnoi terapii ostrogo DVS-sindroma

The discrete plasmapheresis and Fraxiparin were used to optimize the intensive care scheme in acute disseminated intravascular syndrome (DIS). A total of 394 patients underwent the clinical and laboratory examinations to assess the method's efficiency. A lower degree thrombinemia was registered after the therapy versus the original values.

[Effects of basic therapy of ischemic heart disease on vascular-platelet hemostasis during myocardial revascularization]. / Vliianie bazisnoi terapii IBS na sostoianie sosudisto-trombotsitarnogo gemostaza pri operatsii revaskuliarizatsii miokarda.

Effects of preoperative therapy of coronary diseases with calcium antagonists and aspirin on vascular platelet hemostasis during aortocoronary shunting (ACS) have been studied in order to evaluate the role of hemostasis disorders in the pathogenesis of perioperative hemorrhagic complications. Therapy of coronary disease with these drugs during preparation to ACS can involve changes in platelet functional activity, depending on the individual sensitivity of patients. Drug-induced thrombocytopathy can induce pathological hemorrhages in the perioperative period of ACS.

[Change in the level of available lysine under the action of moisture and different types of carbohydrates in the thermal processing of casein and sunflower protein products]. / Izmenenie urovnia dostupnogo lizina pod deistviem vlagi i uglevodov razlichnogo tipa pri termicheskoi obrabotke kazeina i nekotorykh belkovykh produktov podsolnechnika.

Casein, notfat seed meal and extract of the sunflower notfat seed meal were exposed to the effects of moisture, glucose, lactose and saccharose under different thermal conditions to study the degree to which the level of the available lysine falls in all of the study products under the effect of the mentioned factors. Differences in the action of the factors and conditions of technological treatment revealed by the present investigations on the biological value of the protein products justify emphasizing the importance of choosing adequate parameters for each product, together with the need for considering the complexity of physico-chemical and conformable characteristics of the product.