Automatic diagnosis of schizophrenia and attention deficit hyperactivity disorder in rs-fMRI modality using convolutional autoencoder model and interval type-2 fuzzy regression.

Nowadays, many people worldwide suffer from brain disorders, and their health is in danger. So far, numerous methods have been proposed for the diagnosis of Schizophrenia (SZ) and attention deficit hyperactivity disorder (ADHD), among which functional magnetic resonance imaging (fMRI) modalities are known as a popular method among physicians. This paper presents an SZ and ADHD intelligent detection method of resting-state fMRI (rs-fMRI) modality using a new deep learning method. The University of California Los Angeles dataset, which contains the rs-fMRI modalities of SZ and ADHD patients, has been used for experiments. The FMRIB software library toolbox first performed preprocessing on rs-fMRI data. Then, a convolutional Autoencoder model with the proposed number of layers is used to extract features from rs-fMRI data. In the classification step, a new fuzzy method called interval type-2 fuzzy regression (IT2FR) is introduced and then optimized by genetic algorithm, particle swarm optimization, and gray wolf optimization (GWO) techniques. Also, the results of IT2FR methods are compared with multilayer perceptron, k-nearest neighbors, support vector machine, random forest, and decision tree, and adaptive neuro-fuzzy inference system methods. The experiment results show that the IT2FR method with the GWO optimization algorithm has achieved satisfactory results compared to other classifier methods. Finally, the proposed classification technique was able to provide 72.71% accuracy.

INSOMNet: Automated insomnia detection using scalogram and deep neural networks with ECG signals.

Sleep is a natural state of rest for the body and mind. It is essential for a human's physical and mental health because it helps the body restore itself. Insomnia is a sleep disorder that causes difficulty falling asleep or staying asleep and can lead to several health problems. Conventional sleep monitoring and insomnia detection systems are expensive, laborious, and time-consuming. This is the first study that integrates an electrocardiogram (ECG) scalogram with a convolutional neural network (CNN) to develop a model for the accurate measurement of the quality of sleep in identifying insomnia. Continuous wavelet transform has been employed to convert 1-D time-domain ECG signals into 2-D scalograms. Obtained scalograms are fed to AlexNet, MobileNetV2, VGG16, and newly developed CNN for automated detection of insomnia. The proposed INSOMNet system is validated on the cyclic alternating pattern (CAP) and sleep disorder research center (SDRC) datasets. Six performance measures, accuracy (ACC), false omission rate (FOR), sensitivity (SEN), false discovery rate (FDR), specificity (SPE), and threat score (TS), have been calculated to evaluate the developed model. Our developed system attained the classifications ACC of 98.91%, 98.68%, FOR of 1.5, 0.66, SEN of 98.94%, 99.31%, FDR of 0.80, 2.00, SPE of 98.87%, 98.08%, and TS 0.98, 0.97 on CAP and SDRC datasets, respectively. The developed model is less complex and more accurate than transfer-learning networks. The prototype is ready to be tested with a huge dataset from diverse centers.

An automatic sleep-scoring system in elderly women with osteoporosis fractures using frequency localized finite orthogonal quadrature Fejer Korovkin kernels.

Healthy sleep signifies a good physical and mental state of the body. However, factors such as inappropriate work schedules, medical complications, and others can make it difficult to get enough sleep, leading to various sleep disorders. The identification of these disorders requires sleep stage classification. Visual evaluation of sleep stages is time intensive, placing a significant strain on sleep experts and prone to human errors. As a result, it is crucial to develop machine learning algorithms to score sleep stages to acquire an accurate diagnosis. Hence, a new methodology for automated sleep stage classification is suggested using machine learning and filtering electroencephalogram (EEG) signals. The national sleep research resource's (NSRR) study of osteoporotic fractures (SOF) dataset comprising 453 subjects' polysomnograph (PSG) data is used in this study. Only two unipolar EEG derivations C4-A1 and C3-A2 are employed individually and jointly in this work. The EEG signals are decomposed into sub-bands using a frequency-localized finite orthogonal quadrature Fejer Korovkin wavelet filter bank. The wavelet-based entropy features are extracted from sub-bands. Subsequently, extracted features are classified using machine learning techniques. Our developed model obtained the highest classification accuracy of 81.3%, using an ensembled bagged trees classifier with a 10-fold cross-validation method and Cohen's Kappa coefficient of 0.72. The proposed model is accurate, dependable, and easy to implement and can be employed as an alternative to a PSG-based system at home with minimal resources. It is also ready to be tested on other EEG data to evaluate the sleep stages of healthy and unhealthy subjects.

Artificial intelligence, BI-RADS evaluation and morphometry: A novel combination to diagnose breast cancer using ultrasonography, results from multi-center cohorts.

PURPOSE: To develop and validate a machine learning (ML) model for the classification of breast lesions on ultrasound images. METHOD: In the present study, three separate data cohorts containing 1288 breast lesions from three countries (Malaysia, Iran, and Turkey) were utilized for MLmodel development and external validation. The model was trained on ultrasound images of 725 breast lesions, and validation was done separately on the remaining data. An expert radiologist and a radiology resident classified the lesions based on the BI-RADS lexicon. Thirteen morphometric features were selected from a contour of the lesion and underwent a three-step feature selection process. Five features were chosen to be fed into the model separately and combined with the imaging signs mentioned in the BI-RADS reference guide. A support vector classifier was trained and optimized. RESULTS: The diagnostic profile of the model with various input data was compared to the expert radiologist and radiology resident. The agreement of each approach with histopathologic specimens was also determined. Based on BI-RADS and morphometric features, the model achieved an area under the receiver operating characteristic (ROC) curve (AUC) of 0.885, which is higher than the expert radiologist and radiology resident performances with AUC of 0.814 and 0.632, respectively in all cohorts. DeLong's test also showed that the AUC of the ML protocol was significantly different from that of the expert radiologist (ΔAUCs = 0.071, 95%CI: (0.056, 0.086), P = 0.005). CONCLUSIONS: These results support the possible role of morphometric features in enhancing the already well-excepted classification schemes.

Pulse oximetrySpO2signal for automated identification of sleep apnea: a review and future trends.

Sleep apnea (SA) is characterized by intermittent episodes of apnea or hypopnea paused or reduced breathing, respectively each lasting at least ten seconds that occur during sleep. SA has an estimated global prevalence of 200 million and is associated with medical comorbidity, and sufferers are also more likely to sustain traffic- and work-related injury due to daytime somnolence. SA is amenable to treatment if detected early. Polysomnography (PSG) involving multi-channel signal acquisition is the reference standard for diagnosing SA but is onerous and costly. For home-based detection of SA, single-channelSpO2signal acquisition using portable pulse oximeters is feasible. Machine (ML) and deep learning (DL) models have been developed for automated classification of SA versus no SA usingSpO2signals alone. In this work, we review studies published between 2012 and 2022 on the use of ML and DL forSpO2signal-based diagnosis of SA. A literature search based on PRISMA recommendations yielded 297 publications, of which 31 were selected after considering the inclusion and exclusion criteria. There were 20 ML and 11 DL models; their methods, differences, results, merits, and limitations were discussed. Many studies reported encouraging performance, which indicates the utility ofSpO2signals in wearable devices for home-based SA detection.

Novel nested patch-based feature extraction model for automated Parkinson's Disease symptom classification using MRI images.

OBJECTIVE: Parkinson's disease (PD) is a common neurological disorder with variable clinical manifestations and magnetic resonance imaging (MRI) findings. We propose a handcrafted image classification model that can accurately (i) classify different PD stages, (ii) detect comorbid dementia, and (iii) discriminate PD-related motor symptoms. METHODS: Selected image datasets from three PD studies were used to develop the classification model. Our proposed novel automated system was developed in four phases: (i) texture features are extracted from the non-fixed size patches. In the feature extraction phase, a pyramid histogram-oriented gradient (PHOG) image descriptor is used. (ii) In the feature selection phase, four feature selectors: neighborhood component analysis (NCA), Chi2, minimum redundancy maximum relevancy (mRMR), and ReliefF are used to generate four feature vectors. (iii) Two classifiers: k-nearest neighbor (kNN) and support vector machine (SVM) are used in the classification step. A ten-fold cross-validation technique is used to validate the results. (iv) Eight predicted vectors are generated using four selected feature vectors and two classifiers. Finally, iterative majority voting (IMV) is used to attain general classification results. Therefore, this model is named nested patch-PHOG-multiple feature selectors and multiple classifiers-IMV (NP-PHOG-MFSMCIMV). RESULTS: Our presented NP-PHOG-MFSMCIMV model achieved 99.22, 98.70, and 99.53% accuracies for the collected PD stages, PD dementia, and PD symptoms classification datasets, respectively. SIGNIFICANCE: The obtained accuracies (over 98% for all states) demonstrated the performance of developed NP-PHOG-MFSMCIMV model in automated PD state classification.

Tetromino pattern based accurate EEG emotion classification model.

Nowadays, emotion recognition using electroencephalogram (EEG) signals is becoming a hot research topic. The aim of this paper is to classify emotions of EEG signals using a novel game-based feature generation function with high accuracy. Hence, a multileveled handcrafted feature generation automated emotion classification model using EEG signals is presented. A novel textural features generation method inspired by the Tetris game called Tetromino is proposed in this work. The Tetris game is one of the famous games worldwide, which uses various characters in the game. First, the EEG signals are subjected to discrete wavelet transform (DWT) to create various decomposition levels. Then, novel features are generated from the decomposed DWT sub-bands using the Tetromino method. Next, the maximum relevance minimum redundancy (mRMR) features selection method is utilized to select the most discriminative features, and the selected features are classified using support vector machine classifier. Finally, each channel's results (validation predictions) are obtained, and the mode function-based voting method is used to obtain the general results. We have validated our developed model using three databases (DREAMER, GAMEEMO, and DEAP). We have attained 100% accuracies using DREAMER and GAMEEMO datasets. Furthermore, over 99% of classification accuracy is achieved for DEAP dataset. Thus, our developed emotion detection model has yielded the best classification accuracy rate compared to the state-of-the-art techniques and is ready to be tested for clinical application after validating with more diverse datasets. Our results show the success of the presented Tetromino pattern-based EEG signal classification model validated using three public emotional EEG datasets.

Recent Trends in Artificial Intelligence-Assisted Coronary Atherosclerotic Plaque Characterization.

Coronary artery disease is a major cause of morbidity and mortality worldwide. Its underlying histopathology is the atherosclerotic plaque, which comprises lipid, fibrous and-when chronic-calcium components. Intravascular ultrasound (IVUS) and intravascular optical coherence tomography (IVOCT) performed during invasive coronary angiography are reference standards for characterizing the atherosclerotic plaque. Fine image spatial resolution attainable with contemporary coronary computed tomographic angiography (CCTA) has enabled noninvasive plaque assessment, including identifying features associated with vulnerable plaques known to presage acute coronary events. Manual interpretation of IVUS, IVOCT and CCTA images demands scarce physician expertise and high time cost. This has motivated recent research into and development of artificial intelligence (AI)-assisted methods for image processing, feature extraction, plaque identification and characterization. We performed parallel searches of the medical and technical literature from 1995 to 2021 focusing respectively on human plaque characterization using various imaging modalities and the use of AI-assisted computer aided diagnosis (CAD) to detect and classify atherosclerotic plaques, including their composition and the presence of high-risk features denoting vulnerable plaques. A total of 122 publications were selected for evaluation and the analysis was summarized in terms of data sources, methods-machine versus deep learning-and performance metrics. Trends in AI-assisted plaque characterization are detailed and prospective research challenges discussed. Future directions for the development of accurate and efficient CAD systems to characterize plaque noninvasively using CCTA are proposed.

Automated ASD detection using hybrid deep lightweight features extracted from EEG signals.

BACKGROUND: Autism spectrum disorder is a common group of conditions affecting about one in 54 children. Electroencephalogram (EEG) signals from children with autism have a common morphological pattern which makes them distinguishable from normal EEG. We have used this type of signal to design and implement an automated autism detection model. MATERIALS AND METHOD: We propose a hybrid lightweight deep feature extractor to obtain high classification performance. The system was designed and tested with a big EEG dataset that contained signals from autism patients and normal controls. (i) A new signal to image conversion model is presented in this paper. In this work, features are extracted from EEG signal using one-dimensional local binary pattern (1D_LBP) and the generated features are utilized as input of the short time Fourier transform (STFT) to generate spectrogram images. (ii) The deep features of the generated spectrogram images are extracted using a combination of pre-trained MobileNetV2, ShuffleNet, and SqueezeNet models. This method is named hybrid deep lightweight feature generator. (iii) A two-layered ReliefF algorithm is used for feature ranking and feature selection. (iv) The most discriminative features are fed to various shallow classifiers, developed using a 10-fold cross-validation strategy for automated autism detection. RESULTS: A support vector machine (SVM) classifier reached 96.44% accuracy based on features from the proposed model. CONCLUSIONS: The results strongly indicate that the proposed hybrid deep lightweight feature extractor is suitable for autism detection using EEG signals. The model is ready to serve as part of an adjunct tool that aids neurologists during autism diagnosis in medical centers.

An introduction to the Cyrcadia Breast Monitor: A wearable breast health monitoring device.

BACKGROUND: The most common breast cancer detection modalities are generally limited by radiation exposure, discomfort, high costs, inter-observer variabilities in image interpretation, and low sensitivity in detecting cancer in dense breast tissue. Therefore, there is a clear need for an affordable and effective adjunct modality that can address these limitations. The Cyrcadia Breast Monitor (CBM) is a non-invasive, non-compressive, and non-radiogenic wearable device developed as an adjunct to current modalities to assist in the detection of breast tissue abnormalities in any type of breast tissue. METHODS: The CBM records thermodynamic metabolic data from the breast skin surface over a period of time using two wearable biometric patches consisting of eight sensors each and a data recording device. The acquired multi-dimensional temperature time series data are analyzed to determine the presence of breast tissue abnormalities. The objective of this paper is to present the scientific background of CBM and also to describe the history around the design and development of the technology. RESULTS: The results of using the CBM device in the initial clinical studies are also presented. Twenty four-hour long breast skin temperature circadian rhythm data was collected from 93 benign and 108 malignant female study subjects in the initial clinical studies. The predictive model developed using these datasets could differentiate benign and malignant lesions with 78% accuracy, 83.6% sensitivity and 71.5% specificity. A pilot study of 173 female study subjects is underway, in order to validate this predictive model in an independent test population. CONCLUSIONS: The results from the initial studies indicate that the CBM may be valuable for breast health monitoring under physician supervision for confirmation of any abnormal changes, potentially prior to other methods, such as, biopsies. Studies are being conducted and planned to validate the technology and also to evaluate its ability as an adjunct breast health monitoring device for identifying abnormalities in difficult-to-diagnose dense breast tissue.

Classification of heart sound signals using a novel deep WaveNet model.

BACKGROUND AND OBJECTIVES: The high mortality rate and increasing prevalence of heart valve diseases globally warrant the need for rapid and accurate diagnosis of such diseases. Phonocardiogram (PCG) signals are used in this study due to the low cost of obtaining the signals. This study classifies five types of heart sounds, namely normal, aortic stenosis, mitral valve prolapse, mitral stenosis, and mitral regurgitation. METHODS: We have proposed a novel in-house developed deep WaveNet model for automated classification of five types of heart sounds. The model is developed using a total of 1000 PCG recordings belonging to five classes with 200 recordings in each class. RESULTS: We have achieved a training accuracy of 97% for the classification of heart sounds into five classes. The highest classification accuracy of 98.20% was achieved for the normal class. The developed model was validated with a 10-fold cross-validation, thus affirming its robustness. CONCLUSION: The study results clearly indicate that the developed model is able to classify five types of heart sounds accurately. The developed system can be used by cardiologists to aid in the detection of heart valve diseases in patients.

Automated detection of COVID-19 cases using deep neural networks with X-ray images.

The novel coronavirus 2019 (COVID-2019), which first appeared in Wuhan city of China in December 2019, spread rapidly around the world and became a pandemic. It has caused a devastating effect on both daily lives, public health, and the global economy. It is critical to detect the positive cases as early as possible so as to prevent the further spread of this epidemic and to quickly treat affected patients. The need for auxiliary diagnostic tools has increased as there are no accurate automated toolkits available. Recent findings obtained using radiology imaging techniques suggest that such images contain salient information about the COVID-19 virus. Application of advanced artificial intelligence (AI) techniques coupled with radiological imaging can be helpful for the accurate detection of this disease, and can also be assistive to overcome the problem of a lack of specialized physicians in remote villages. In this study, a new model for automatic COVID-19 detection using raw chest X-ray images is presented. The proposed model is developed to provide accurate diagnostics for binary classification (COVID vs. No-Findings) and multi-class classification (COVID vs. No-Findings vs. Pneumonia). Our model produced a classification accuracy of 98.08% for binary classes and 87.02% for multi-class cases. The DarkNet model was used in our study as a classifier for the you only look once (YOLO) real time object detection system. We implemented 17 convolutional layers and introduced different filtering on each layer. Our model (available at (https://github.com/muhammedtalo/COVID-19)) can be employed to assist radiologists in validating their initial screening, and can also be employed via cloud to immediately screen patients.

1D-CADCapsNet: One dimensional deep capsule networks for coronary artery disease detection using ECG signals.

PURPOSE: Cardiovascular disease (CVD) is a leading cause of death globally. Electrocardiogram (ECG), which records the electrical activity of the heart, has been used for the diagnosis of CVD. The automated and robust detection of CVD from ECG signals plays a significant role for early and accurate clinical diagnosis. The purpose of this study is to provide automated detection of coronary artery disease (CAD) from ECG signals using capsule networks (CapsNet). METHODS: Deep learning-based approaches have become increasingly popular in computer aided diagnosis systems. Capsule networks are one of the new promising approaches in the field of deep learning. In this study, we used 1D version of CapsNet for the automated detection of coronary artery disease (CAD) on two second (95,300) and five second-long (38,120) ECG segments. These segments are obtained from 40 normal and 7 CAD subjects. In the experimental studies, 5-fold cross validation technique is employed to evaluate performance of the model. RESULTS: The proposed model, which is named as 1D-CADCapsNet, yielded a promising 5-fold diagnosis accuracy of 99.44% and 98.62% for two- and five-second ECG signal groups, respectively. We have obtained the highest performance results using 2 s ECG segment than the state-of-art studies reported in the literature. CONCLUSIONS: 1D-CADCapsNet model automatically learns the pertinent representations from raw ECG data without using any hand-crafted technique and can be used as a fast and accurate diagnostic tool to help cardiologists.

Brain pathology identification using computer aided diagnostic tool: A systematic review.

Computer aided diagnostic (CAD) has become a significant tool in expanding patient quality-of-life by reducing human errors in diagnosis. CAD can expedite decision-making on complex clinical data automatically. Since brain diseases can be fatal, rapid identification of brain pathology to prolong patient life is an important research topic. Many algorithms have been proposed for efficient brain pathology identification (BPI) over the past decade. Constant refinement of the various image processing algorithms must take place to expand performance of the automatic BPI task. In this paper, a systematic survey of contemporary BPI algorithms using brain magnetic resonance imaging (MRI) is presented. A summarization of recent literature provides investigators with a helpful synopsis of the domain. Furthermore, to enhance the performance of BPI, future research directions are indicated.

Automated plaque classification using computed tomography angiography and Gabor transformations.

Cardiovascular diseases are the primary cause of death globally. These are often associated with atherosclerosis. This inflammation process triggers important variations in the coronary arteries (CA) and can lead to coronary artery disease (CAD). The presence of CA calcification (CAC) has recently been shown to be a strong predictor of CAD. In this clinical setting, computed tomography angiography (CTA) has begun to play a crucial role as a non-intrusive imaging method to characterize and study CA plaques. Herein, we describe an automated algorithm to classify plaque as either normal, calcified, or non-calcified using 2646 CTA images acquired from 73 patients. The automated technique is based on various features that are extracted from the Gabor transform of the acquired CTA images. Specifically, seven features are extracted from the Gabor coefficients : energy, and Kapur, Max, Rényi, Shannon, Vajda, and Yager entropies. The features were then ordered based on the F-value and input to numerous classification methods to achieve the best classification accuracy with the least number of features. Moreover, two well-known feature reduction techniques were employed, and the features acquired were also ranked according to F-value and input to several classifiers. The best classification results were obtained using all computed features without the employment of feature reduction, using a probabilistic neural network. An accuracy, positive predictive value, sensitivity, and specificity of 89.09%, 91.70%, 91.83% and 83.70% was obtained, respectively. Based on these results, it is evident that the technique can be helpful in the automated classification of plaques present in CTA images, and may become an important tool to reduce procedural costs and patient radiation dose. This could also aid clinicians in plaque diagnostics.

An efficient data mining framework for the characterization of symptomatic and asymptomatic carotid plaque using bidimensional empirical mode decomposition technique.

Atherosclerosis is a type of cardiovascular disease which may cause stroke. It is due to the deposition of fatty plaque in the artery walls resulting in the reduction of elasticity gradually and hence restricting the blood flow to the heart. Hence, an early prediction of carotid plaque deposition is important, as it can save lives. This paper proposes a novel data mining framework for the assessment of atherosclerosis in its early stage using ultrasound images. In this work, we are using 1353 symptomatic and 420 asymptomatic carotid plaque ultrasound images. Our proposed method classifies the symptomatic and asymptomatic carotid plaques using bidimensional empirical mode decomposition (BEMD) and entropy features. The unbalanced data samples are compensated using adaptive synthetic sampling (ADASYN), and the developed method yielded a promising accuracy of 91.43%, sensitivity of 97.26%, and specificity of 83.22% using fourteen features. Hence, the proposed method can be used as an assisting tool during the regular screening of carotid arteries in hospitals. Graphical abstract Outline for our efficient data mining framework for the characterization of symptomatic and asymptomatic carotid plaques.

Fusion of spatial gray level dependency and fractal texture features for the characterization of thyroid lesions.

Thyroid is a small gland situated at the anterior side of the neck and one of the largest glands of the endocrine system. The abrupt cell growth or malignancy in the thyroid gland may cause thyroid cancer. Ultrasound images distinctly represent benign and malignant lesions, but accuracy may be poor due to subjective interpretation. Computer Aided Diagnosis (CAD) can minimize the errors created due to subjective interpretation and assists to make fast accurate diagnosis. In this work, fusion of Spatial Gray Level Dependence Features (SGLDF) and fractal textures are used to decipher the intrinsic structure of benign and malignant thyroid lesions. These features are subjected to graph based Marginal Fisher Analysis (MFA) to reduce the number of features. The reduced features are subjected to various ranking methods and classifiers. We have achieved an average accuracy, sensitivity and specificity of 97.52%, 90.32% and 98.57% respectively using Support Vector Machine (SVM) classifier. The achieved maximum Area Under Curve (AUC) is 0.9445. Finally, Thyroid Clinical Risk Index (TCRI) a single number is developed using two MFA features to discriminate the two classes. This prototype system is ready to be tested with huge diverse database.

The role of real-time in biomedical science: a meta-analysis on computational complexity, delay and speedup.

PURPOSE: The concept of real-time is very important, as it deals with the realizability of computer based health care systems. METHOD: In this paper we review biomedical real-time systems with a meta-analysis on computational complexity (CC), delay (Δ) and speedup (Sp). RESULTS: During the review we found that, in the majority of papers, the term real-time is part of the thesis indicating that a proposed system or algorithm is practical. However, these papers were not considered for detailed scrutiny. Our detailed analysis focused on papers which support their claim of achieving real-time, with a discussion on CC or Sp. These papers were analyzed in terms of processing system used, application area (AA), CC, Δ, Sp, implementation/algorithm (I/A) and competition. CONCLUSIONS: The results show that the ideas of parallel processing and algorithm delay were only recently introduced and journal papers focus more on Algorithm (A) development than on implementation (I). Most authors compete on big O notation (O) and processing time (PT). Based on these results, we adopt the position that the concept of real-time will continue to play an important role in biomedical systems design. We predict that parallel processing considerations, such as Sp and algorithm scaling, will become more important.

Application of infrared thermography in computer aided diagnosis.

The invention of thermography, in the 1950s, posed a formidable problem to the research community: What is the relationship between disease and heat radiation captured with Infrared (IR) cameras? The research community responded with a continuous effort to find this crucial relationship. This effort was aided by advances in processing techniques, improved sensitivity and spatial resolution of thermal sensors. However, despite this progress fundamental issues with this imaging modality still remain. The main problem is that the link between disease and heat radiation is complex and in many cases even non-linear. Furthermore, the change in heat radiation as well as the change in radiation pattern, which indicate disease, is minute. On a technical level, this poses high requirements on image capturing and processing. On a more abstract level, these problems lead to inter-observer variability and on an even more abstract level they lead to a lack of trust in this imaging modality. In this review, we adopt the position that these problems can only be solved through a strict application of scientific principles and objective performance assessment. Computing machinery is inherently objective; this helps us to apply scientific principles in a transparent way and to assess the performance results. As a consequence, we aim to promote thermography based Computer-Aided Diagnosis (CAD) systems. Another benefit of CAD systems comes from the fact that the diagnostic accuracy is linked to the capability of the computing machinery and, in general, computers become ever more potent. We predict that a pervasive application of computers and networking technology in medicine will help us to overcome the shortcomings of any single imaging modality and this will pave the way for integrated health care systems which maximize the quality of patient care.

Ensemble selection for feature-based classification of diabetic maculopathy images.

As diabetic maculopathy (DM) is a prevalent cause of blindness in the world, it is increasingly important to use automated techniques for the early detection of the disease. In this paper, we propose a decision system to classify DM fundus images into normal, clinically significant macular edema (CMSE), and non-clinically significant macular edema (non-CMSE) classes. The objective of the proposed decision system is three fold namely, to automatically extract textural features (both region specific and global), to effectively choose subset of discriminatory features, and to classify DM fundus images to their corresponding class of disease severity. The system uses a gamut of textural features and an ensemble classifier derived from four popular classifiers such as the hidden naïve Bayes, naïve Bayes, sequential minimal optimization (SMO), and the tree-based J48 classifiers. We achieved an average classification accuracy of 96.7% using five-fold cross validation.