1.
Bioorg Med Chem Lett
; 17(22): 6270-3, 2007 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-17911024
ABSTRACT
The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.
Subject(s)
Adrenergic beta-3 Receptor Agonists , Adrenergic beta-Agonists/chemical synthesis , Adrenergic beta-Agonists/pharmacology , Indoles/chemical synthesis , Indoles/pharmacology , Tachycardia/drug therapy , Adrenergic beta-Agonists/chemistry , Animals , CHO Cells , Cricetinae , Cricetulus , Disease Models, Animal , Drug Evaluation, Preclinical , Humans , Indoles/chemistry , Molecular Structure , Oxindoles , Rats , Rats, Long-Evans , Receptors, Adrenergic, beta-3/biosynthesis , Receptors, Adrenergic, beta-3/genetics
2.
Bioorg Med Chem Lett
; 16(21): 5691-4, 2006 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-16931005
ABSTRACT
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.