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J Theor Biol ; 593: 111894, 2024 Oct 07.
Article in English | MEDLINE | ID: mdl-38992463

ABSTRACT

In this paper, we explore the effects of biological (pathological) and mechanical damage on bone tissue within a benchmark model. Using the Finite Element Methodology, we analyze and numerically test the model's components, capabilities, and performance under physiologically and pathologically relevant conditions. Our findings demonstrate the model's effectiveness in simulating bone remodeling processes and self-repair mechanisms for micro-damage induced by biological internal conditions and mechanical external ones within bone tissue. This article is the second part of a series, where the first part presented the mathematical model and the biological and physical significance of the terms used in a simplified benchmark model. It explored the bone remodeling model's application, implementation, and results under physiological conditions.


Subject(s)
Bone Remodeling , Models, Biological , Bone Remodeling/physiology , Humans , Biomechanical Phenomena , Finite Element Analysis , Bone and Bones/physiology , Bone and Bones/pathology , Animals , Stress, Mechanical , Computer Simulation
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