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Arch Virol
; 168(7): 179, 2023 Jun 13.
Article
in English
| MEDLINE
| ID: mdl-37310539
ABSTRACT
Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We show that substitution of a neutralising tip domain of BTV8 VP2 with that of BTV1 VP2 resulted in the assembly of VLPs that stimulated serotype-specific antibodies as well as virus-specific neutralising antibodies.
Subject(s)
Bluetongue virus , Bluetongue , Vaccines, Virus-Like Particle , Animals , Sheep , Bluetongue virus/genetics , Antibodies , Bluetongue/prevention & control , Serogroup , Vaccines, Virus-Like Particle/genetics
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