Deep Learning Reconstruction of Prospectively Accelerated MRI of the Pancreas: Clinical Evaluation of Shortened Breath-Hold Examinations With Dixon Fat Suppression.

OBJECTIVE: Deep learning (DL)-enabled magnetic resonance imaging (MRI) reconstructions can enable shortening of breath-hold examinations and improve image quality by reducing motion artifacts. Prospective studies with DL reconstructions of accelerated MRI of the upper abdomen in the context of pancreatic pathologies are lacking. In a clinical setting, the purpose of this study is to investigate the performance of a novel DL-based reconstruction algorithm in T1-weighted volumetric interpolated breath-hold examinations with partial Fourier sampling and Dixon fat suppression (hereafter, VIBE-DixonDL). The objective is to analyze its impact on acquisition time, image sharpness and quality, diagnostic confidence, pancreatic lesion conspicuity, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). METHODS: This prospective single-center study included participants with various pancreatic pathologies who gave written consent from January 2023 to September 2023. During the same session, each participant underwent 2 MRI acquisitions using a 1.5 T scanner: conventional precontrast and postcontrast T1-weighted VIBE acquisitions with Dixon fat suppression (VIBE-Dixon, reference standard) using 4-fold parallel imaging acceleration and 6-fold accelerated VIBE-Dixon acquisitions with partial Fourier sampling utilizing a novel DL reconstruction tailored to the acquisition. A qualitative image analysis was performed by 4 readers. Acquisition time, image sharpness, overall image quality, image noise and artifacts, diagnostic confidence, as well as pancreatic lesion conspicuity and size were compared. Furthermore, a quantitative analysis of SNR and CNR was performed. RESULTS: Thirty-two participants were evaluated (mean age ± SD, 62 ± 19 years; 20 men). The VIBE-DixonDL method enabled up to 52% reduction in average breath-hold time (7 seconds for VIBE-DixonDL vs 15 seconds for VIBE-Dixon, P < 0.001). A significant improvement of image sharpness, overall image quality, diagnostic confidence, and pancreatic lesion conspicuity was observed in the images recorded using VIBE-DixonDL (P < 0.001). Furthermore, a significant reduction of image noise and motion artifacts was noted in the images recorded using the VIBE-DixonDL technique (P < 0.001). In addition, for all readers, there was no evidence of a difference in lesion size measurement between VIBE-Dixon and VIBE-DixonDL. Interreader agreement between VIBE-Dixon and VIBE-DixonDL regarding lesion size was excellent (intraclass correlation coefficient, >90). Finally, a statistically significant increase of pancreatic SNR in VIBE-DIXONDL was observed in both the precontrast (P = 0.025) and postcontrast images (P < 0.001). Also, an increase of splenic SNR in VIBE-DIXONDL was observed in both the precontrast and postcontrast images, but only reaching statistical significance in the postcontrast images (P = 0.34 and P = 0.003, respectively). Similarly, an increase of pancreas CNR in VIBE-DIXONDL was observed in both the precontrast and postcontrast images, but only reaching statistical significance in the postcontrast images (P = 0.557 and P = 0.026, respectively). CONCLUSIONS: The prospectively accelerated, DL-enhanced VIBE with Dixon fat suppression was clinically feasible. It enabled a 52% reduction in breath-hold time and provided superior image quality, diagnostic confidence, and pancreatic lesion conspicuity. This technique might be especially useful for patients with limited breath-hold capacity.

Prospective Deployment of Deep Learning Reconstruction Facilitates Highly Accelerated Upper Abdominal MRI.

RATIONALE AND OBJECTIVES: To compare a conventional T1 volumetric interpolated breath-hold examination (VIBE) with SPectral Attenuated Inversion Recovery (SPAIR) fat saturation and a deep learning (DL)-reconstructed accelerated VIBE sequence with SPAIR fat saturation achieving a 50 % reduction in breath-hold duration (hereafter, VIBE-SPAIRDL) in terms of image quality and diagnostic confidence. MATERIALS AND METHODS: This prospective study enrolled consecutive patients referred for upper abdominal MRI from November 2023 to December 2023 at a single tertiary center. Patients underwent upper abdominal MRI with acquisition of non-contrast and gadobutrol-enhanced conventional VIBE-SPAIR (fourfold acceleration, acquisition time 16 s) and VIBE-SPAIRDL (sixfold acceleration, acquisition time 8 s) on a 1.5 T scanner. Image analysis was performed by four readers, evaluating homogeneity of fat suppression, perceived signal-to-noise ratio (SNR), edge sharpness, artifact level, lesion detectability and diagnostic confidence. A statistical power analysis for patient sample size estimation was performed. Image quality parameters were compared by a repeated measures analysis of variance, and interreader agreement was assessed using Fleiss' κ. RESULTS: Among 450 consecutive patients, 45 patients were evaluated (mean age, 60 years ± 15 [SD]; 27 men, 18 women). VIBE-SPAIRDL acquisition demonstrated superior SNR (P < 0.001), edge sharpness (P < 0.001), and reduced artifacts (P < 0.001) with substantial to almost perfect interreader agreement for non-contrast (κ: 0.70-0.91) and gadobutrol-enhanced MRI (κ: 0.68-0.87). No evidence of a difference was found between conventional VIBE-SPAIR and VIBE-SPAIRDL regarding homogeneity of fat suppression, lesion detectability, or diagnostic confidence (all P > 0.05). CONCLUSION: Deep learning reconstruction of VIBE-SPAIR facilitated a reduction of breath-hold duration by half, while reducing artifacts and improving image quality. SUMMARY: Deep learning reconstruction of prospectively accelerated T1 volumetric interpolated breath-hold examination for upper abdominal MRI enabled a 50 % reduction in breath-hold time with superior image quality. KEY RESULTS: 1) In a prospective analysis of 45 patients referred for upper abdominal MRI, accelerated deep learning (DL)-reconstructed VIBE images with spectral fat saturation (SPAIR) showed better overall image quality, with better perceived signal-to-noise ratio and less artifacts (all P < 0.001), despite a 50 % reduction in acquisition time compared to conventional VIBE. 2) No evidence of a difference was found between conventional VIBE-SPAIR and accelerated VIBE-SPAIRDL regarding lesion detectability or diagnostic confidence.

Deep-learning denoising minimizes radiation exposure in neck CT beyond the limits of conventional reconstruction.

BACKGROUND: Neck computed tomography (NCT) is essential for diagnosing suspected neck tumors and abscesses, but radiation exposure can be an issue. In conventional reconstruction techniques, limiting radiation dose comes at the cost of diminished diagnostic accuracy. Therefore, this study aimed to evaluate the effects of an AI-based denoising post-processing software solution in low-dose neck computer tomography. MATERIALS AND METHODS: From 01 September 2023 to 01 December 2023, we retrospectively included patients with clinically suspected neck tumors from the same single-source scanner. The scans were reconstructed using Advanced Modeled Iterative Reconstruction (Original) at 100% and simulated 50% and 25% radiation doses. Each dataset was post-processed using a novel denoising software solution (Denoising). Three radiologists with varying experience levels subjectively rated image quality, diagnostic confidence, sharpness, and contrast for all pairwise combinations of radiation dose and reconstruction mode in a randomized, blinded forced-choice setup. Objective image quality was assessed using ROI measurements of mean CT numbers, noise, and a contrast-to-noise ratio (CNR). An adequately corrected mixed-effects analysis was used to compare objective and subjective image quality. RESULTS: At each radiation dose level, pairwise comparisons showed significantly lower image noise and higher CNR for Denoising than for Original (p < 0.001). In subjective analysis, image quality, diagnostic confidence, sharpness, and contrast were significantly higher for Denoising than for Original at 100 and 50 % (p < 0.001). However, there were no significant differences in the subjective ratings between Original 100 % and Denoising 25 % (p = 0.906). CONCLUSIONS: The investigated denoising algorithm enables diagnostic-quality neck CT images with radiation doses reduced to 25% of conventional levels, significantly minimizing patient exposure.

Evaluating ChatGPT-4V in chest CT diagnostics: a critical image interpretation assessment.

PURPOSE: To assess the diagnostic accuracy of ChatGPT-4V in interpreting a set of four chest CT slices for each case of COVID-19, non-small cell lung cancer (NSCLC), and control cases, thereby evaluating its potential as an AI tool in radiological diagnostics. MATERIALS AND METHODS: In this retrospective study, 60 CT scans from The Cancer Imaging Archive, covering COVID-19, NSCLC, and control cases were analyzed using ChatGPT-4V. A radiologist selected four CT slices from each scan for evaluation. ChatGPT-4V's interpretations were compared against the gold standard diagnoses and assessed by two radiologists. Statistical analyses focused on accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), along with an examination of the impact of pathology location and lobe involvement. RESULTS: ChatGPT-4V showed an overall diagnostic accuracy of 56.76%. For NSCLC, sensitivity was 27.27% and specificity was 60.47%. In COVID-19 detection, sensitivity was 13.64% and specificity of 64.29%. For control cases, the sensitivity was 31.82%, with a specificity of 95.24%. The highest sensitivity (83.33%) was observed in cases involving all lung lobes. The chi-squared statistical analysis indicated significant differences in Sensitivity across categories and in relation to the location and lobar involvement of pathologies. CONCLUSION: ChatGPT-4V demonstrated variable diagnostic performance in chest CT interpretation, with notable proficiency in specific scenarios. This underscores the challenges of cross-modal AI models like ChatGPT-4V in radiology, pointing toward significant areas for improvement to ensure dependability. The study emphasizes the importance of enhancing these models for broader, more reliable medical use.

Influence of helical pitch and gantry rotation time on image quality and file size in ultrahigh-resolution photon-counting detector CT.

The goal of this experimental study was to quantify the influence of helical pitch and gantry rotation time on image quality and file size in ultrahigh-resolution photon-counting CT (UHR-PCCT). Cervical and lumbar spine, pelvis, and upper legs of two fresh-frozen cadaveric specimens were subjected to nine dose-matched UHR-PCCT scan protocols employing a collimation of 120 × 0.2 mm with varying pitch (0.3/1.0/1.2) and rotation time (0.25/0.5/1.0 s). Image quality was analyzed independently by five radiologists and further substantiated by placing normed regions of interest to record mean signal attenuation and noise. Effective mAs, CT dose index (CTDIvol), size-specific dose estimate (SSDE), scan duration, and raw data file size were compared. Regardless of anatomical region, no significant difference was ascertained for CTDIvol (p ≥ 0.204) and SSDE (p ≥ 0.240) among protocols. While exam duration differed substantially (all p ≤ 0.016), the lowest scan time was recorded for high-pitch protocols (4.3 ± 1.0 s) and the highest for low-pitch protocols (43.6 ± 15.4 s). The combination of high helical pitch and short gantry rotation times produced the lowest perceived image quality (intraclass correlation coefficient 0.866; 95% confidence interval 0.807-0.910; p < 0.001) and highest noise. Raw data size increased with acquisition time (15.4 ± 5.0 to 235.0 ± 83.5 GByte; p ≤ 0.013). Rotation time and pitch factor have considerable influence on image quality in UHR-PCCT and must therefore be chosen deliberately for different musculoskeletal imaging tasks. In examinations with long acquisition times, raw data size increases considerably, consequently limiting clinical applicability for larger scan volumes.

Fast 5-minute shoulder MRI protocol with accelerated TSE-sequences and deep learning image reconstruction for the assessment of shoulder pain at 1.5 and 3 Tesla.

Purpose: The objective of this study was to implement a 5-minute MRI protocol for the shoulder in routine clinical practice consisting of accelerated 2D turbo spin echo (TSE) sequences with deep learning (DL) reconstruction at 1.5 and 3 Tesla, and to compare the image quality and diagnostic performance to that of a standard 2D TSE protocol. Methods: Patients undergoing shoulder MRI between October 2020 and June 2021 were prospectively enrolled. Each patient underwent two MRI examinations: first a standard, fully sampled TSE (TSES) protocol reconstructed with a standard reconstruction followed by a second fast, prospectively undersampled TSE protocol with a conventional parallel imaging undersampling pattern reconstructed with a DL reconstruction (TSEDL). Image quality and visualization of anatomic structures as well as diagnostic performance with respect to shoulder lesions were assessed using a 5-point Likert-scale (5 = best). Interchangeability analysis, Wilcoxon signed-rank test and kappa statistics were performed to compare the two protocols. Results: A total of 30 participants was included (mean age 50±15 years; 15 men). Overall image quality was evaluated to be superior in TSEDL versus TSES (p<0.001). Noise and edge sharpness were evaluated to be significantly superior in TSEDL versus TSES (noise: p<0.001, edge sharpness: p<0.05). No difference was found concerning qualitative diagnostic confidence, assessability of anatomical structures (p>0.05), and quantitative diagnostic performance for shoulder lesions when comparing the two sequences. Conclusions: A fast 5-minute TSEDL MRI protocol of the shoulder is feasible in routine clinical practice at 1.5 and 3 T, with interchangeable results concerning the diagnostic performance, allowing a reduction in scan time of more than 50% compared to the standard TSES protocol.

How young radiologists use contrast media and manage adverse reactions: an international survey.

OBJECTIVES: To collect real-world data about the knowledge and self-perception of young radiologists concerning the use of contrast media (CM) and the management of adverse drug reactions (ADR). METHODS: A survey (29 questions) was distributed to residents and board-certified radiologists younger than 40 years to investigate the current international situation in young radiology community regarding CM and ADRs. Descriptive statistics analysis was performed. RESULTS: Out of 454 respondents from 48 countries (mean age: 31.7 ± 4 years, range 25-39), 271 (59.7%) were radiology residents and 183 (40.3%) were board-certified radiologists. The majority (349, 76.5%) felt they were adequately informed regarding the use of CM. However, only 141 (31.1%) received specific training on the use of CM and 82 (18.1%) about management ADR during their residency. Although 266 (58.6%) knew safety protocols for handling ADR, 69.6% (316) lacked confidence in their ability to manage CM-induced ADRs and 95.8% (435) expressed a desire to enhance their understanding of CM use and handling of CM-induced ADRs. Nearly 300 respondents (297; 65.4%) were aware of the benefits of contrast-enhanced ultrasound, but 249 (54.8%) of participants did not perform it. The preferred CM injection strategy in CT parenchymal examination and CT angiography examination was based on patient's lean body weight in 318 (70.0%) and 160 (35.2%), a predeterminate fixed amount in 79 (17.4%) and 116 (25.6%), iodine delivery rate in 26 (5.7%) and 122 (26.9%), and scan time in 31 (6.8%) and 56 (12.3%), respectively. CONCLUSION: Training in CM use and management ADR should be implemented in the training of radiology residents. CRITICAL RELEVANCE STATEMENT: We highlight the need for improvement in the education of young radiologists regarding contrast media; more attention from residency programs and scientific societies should be focused on training about contrast media use and the management of adverse drug reactions. KEY POINTS: • This survey investigated training of young radiologists about use of contrast media and management adverse reactions. • Most young radiologists claimed they did not receive dedicated training. • An extreme heterogeneity of responses was observed about contrast media indications/contraindications and injection strategy.

Standardization of a CT Protocol for Imaging Patients with Suspected COVID-19-A RACOON Project.

CT protocols that diagnose COVID-19 vary in regard to the associated radiation exposure and the desired image quality (IQ). This study aims to evaluate CT protocols of hospitals participating in the RACOON (Radiological Cooperative Network) project, consolidating CT protocols to provide recommendations and strategies for future pandemics. In this retrospective study, CT acquisitions of COVID-19 patients scanned between March 2020 and October 2020 (RACOON phase 1) were included, and all non-contrast protocols were evaluated. For this purpose, CT protocol parameters, IQ ratings, radiation exposure (CTDIvol), and central patient diameters were sampled. Eventually, the data from 14 sites and 534 CT acquisitions were analyzed. IQ was rated good for 81% of the evaluated examinations. Motion, beam-hardening artefacts, or image noise were reasons for a suboptimal IQ. The tube potential ranged between 80 and 140 kVp, with the majority between 100 and 120 kVp. CTDIvol was 3.7 ± 3.4 mGy. Most healthcare facilities included did not have a specific non-contrast CT protocol. Furthermore, CT protocols for chest imaging varied in their settings and radiation exposure. In future, it will be necessary to make recommendations regarding the required IQ and protocol parameters for the majority of CT scanners to enable comparable IQ as well as radiation exposure for different sites but identical diagnostic questions.

Image Quality and Diagnostic Performance of Low-Dose Liver CT with Deep Learning Reconstruction versus Standard-Dose CT.

Purpose To compare the image quality and diagnostic capability in detecting malignant liver tumors of low-dose CT (LDCT, 33% dose) with deep learning-based denoising (DLD) and standard-dose CT (SDCT, 100% dose) with model-based iterative reconstruction (MBIR). Materials and Methods In this prospective, multicenter, noninferiority study, individuals referred for liver CT scans were enrolled from three tertiary referral hospitals between February 2021 and August 2022. All liver CT scans were conducted using a dual-source scanner with the dose split into tubes A (67% dose) and B (33% dose). Blended images from tubes A and B were created using MBIR to produce SDCT images, whereas LDCT images used data from tube B and were reconstructed with DLD. The noise in liver images was measured and compared between imaging techniques. The diagnostic performance of each technique in detecting malignant liver tumors was evaluated by three independent radiologists using jackknife alternative free-response receiver operating characteristic analysis. Noninferiority of LDCT compared with SDCT was declared when the lower limit of the 95% CI for the difference in figure of merit (FOM) was greater than -0.10. Results A total of 296 participants (196 men, 100 women; mean age, 60.5 years ± 13.3 [SD]) were included. The mean noise level in the liver was significantly lower for LDCT (10.1) compared with SDCT (10.7) (P < .001). Diagnostic performance was assessed in 246 participants (108 malignant tumors in 90 participants). The reader-averaged FOM was 0.880 for SDCT and 0.875 for LDCT (P = .35). The difference fell within the noninferiority margin (difference, -0.005 [95% CI: -0.024, 0.012]). Conclusion Compared with SDCT with MBIR, LDCT using 33% of the standard radiation dose had reduced image noise and comparable diagnostic performance in detecting malignant liver tumors. Keywords: CT, Abdomen/GI, Liver, Comparative Studies, Diagnosis, Reconstruction Algorithms Clinical trial registration no. NCT05804799 © RSNA, 2024 Supplemental material is available for this article.

Towards safer imaging: A comparative study of deep learning-based denoising and iterative reconstruction in intraindividual low-dose CT scans using an in-vivo large animal model.

PURPOSE: Computed tomography (CT) scans are a significant source of medically induced radiation exposure. Novel deep learning-based denoising (DLD) algorithms have been shown to enable diagnostic image quality at lower radiation doses than iterative reconstruction (IR) methods. However, most comparative studies employ low-dose simulations due to ethical constraints. We used real intraindividual animal scans to investigate the dose-reduction capabilities of a DLD algorithm in comparison to IR. MATERIALS AND METHODS: Fourteen veterinarian-sedated alive pigs underwent 2 CT scans on the same 3rd generation dual-source scanner with two months between each scan. Four additional scans ensued each time, with mAs reduced to 50 %, 25 %, 10 %, and 5 %. All scans were reconstructed ADMIRE levels 2 (IR2) and a novel DLD algorithm, resulting in 280 datasets. Objective image quality (CT numbers stability, noise, and contrast-to-noise ratio) was measured via consistent regions of interest. Three radiologists independently rated all possible dataset combinations per time point for subjective image quality (-1 = inferior, 0 = equal, 1 = superior). The points were averaged for a semiquantitative score, and inter-rater agreement was measured using Spearman's correlation coefficient and adequately corrected mixed-effects modeling analyzed objective and subjective image quality. RESULTS: Neither dose-reduction nor reconstruction method negatively impacted CT number stability (p > 0.999). In objective image quality assessment, the lowest radiation dose achievable by DLD when comparing noise (p = 0.544) and CNR (p = 0.115) to 100 % IR2 was 25 %. Overall, inter-rater agreement of the subjective image quality ratings was strong (r ≥ 0.69, mean 0.93 ± 0.05, 95 % CI 0.92-0.94; each p < 0.001), and subjective assessments corroborated that DLD at 25 % radiation dose was comparable to 100 % IR2 in image quality, sharpness, and contrast (p ≥ 0.281). CONCLUSIONS: The DLD algorithm can achieve image quality comparable to the standard IR method but with a significant dose reduction of up to 75%. This suggests a promising avenue for lowering patient radiation exposure without sacrificing diagnostic quality.

Cost-effectiveness of endovascular treatment versus best medical management in basilar artery occlusion stroke: A U.S. healthcare perspective.

INTRODUCTION: Two recent studies showed clinical benefit for endovascular treatment (EVT) in basilar artery occlusion (BAO) stroke up to 12 h (ATTENTION) and between 6 and 24 h from onset (BAOCHE). Our aim was to investigate the cost-effectiveness of EVT from a U.S. healthcare perspective. MATERIALS AND METHODS: Clinical input data were available for both trials, which were analyzed separately. A decision model was built consisting of a short-run model to analyze costs and functional outcomes within 90 days after the index stroke and a long-run Markov state transition model (cycle length of 12 months) to estimate expected lifetime costs and outcomes from a healthcare and a societal perspective. Incremental cost-effectiveness ratios (ICER) were calculated, deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed. RESULTS: EVT in addition to best medical management (BMM) resulted in additional lifetime costs of $32,063 in the ATTENTION trial and lifetime cost savings of $7690 in the BAOCHE trial (societal perspective). From a healthcare perspective, EVT led to incremental costs and effectiveness of $37,389 and 2.0 QALYs (ATTENTION) as well as $3516 and 1.9 QALYs (BAOCHE), compared to BMM alone. The ICER values were $-4052/QALY (BAOCHE) and $15,867/QALY (ATTENTION) from a societal perspective. In each trial, PSA showed EVT to be cost-effective in most calculations (99.9%) for a willingness-to-pay threshold of $100,000/QALY. Cost of EVT and age at stroke represented the greatest impact on the ICER. DISCUSSION: From an economic standpoint with a lifetime horizon, EVT in addition to BMM is estimated to be highly effective and cost-effective in BAO stroke.

Investigating the Small Pixel Effect in Ultra-High Resolution Photon-Counting CT of the Lung.

OBJECTIVES: The aim of this study was to investigate potential benefits of ultra-high resolution (UHR) over standard resolution scan mode in ultra-low dose photon-counting detector CT (PCD-CT) of the lung. MATERIALS AND METHODS: Six cadaveric specimens were examined with 5 dose settings using tin prefiltration, each in UHR (120 × 0.2 mm) and standard mode (144 × 0.4 mm), on a first-generation PCD-CT scanner. Image quality was evaluated quantitatively by noise comparisons in the trachea and both main bronchi. In addition, 16 readers (14 radiologists and 2 internal medicine physicians) independently completed a browser-based pairwise forced-choice comparison task for assessment of subjective image quality. The Kendall rank coefficient ( W ) was calculated to assess interrater agreement, and Pearson's correlation coefficient ( r ) was used to analyze the relationship between noise measurements and image quality rankings. RESULTS: Across all dose levels, image noise in UHR mode was lower than in standard mode for scan protocols matched by CTDI vol ( P < 0.001). UHR examinations exhibited noise levels comparable to the next higher dose setting in standard mode ( P ≥ 0.275). Subjective ranking of protocols based on 5760 pairwise tests showed high interrater agreement ( W = 0.99; P ≤ 0.001) with UHR images being preferred by readers in the majority of comparisons. Irrespective of scan mode, a substantial indirect correlation was observed between image noise and subjective image quality ranking ( r = -0.97; P ≤ 0.001). CONCLUSIONS: In PCD-CT of the lung, UHR scan mode reduces image noise considerably over standard resolution acquisition. Originating from the smaller detector element size in fan direction, the small pixel effect allows for superior image quality in ultra-low dose examinations with considerable potential for radiation dose reduction.

Ultra-high resolution photon-counting CT with tin prefiltration for bone-metal interface visualization.

PURPOSE: To investigate the metal artifact suppression potential of combining tin prefiltration and virtual monoenergetic imaging (VMI) for osseous microarchitecture depiction in ultra-high-resolution (UHR) photon-counting CT (PCCT) of the lower extremity. METHOD: Derived from tin-filtered UHR scans at 140 kVp, polychromatic datasets (T3D) and VMI reconstructions at 70, 110, 150, and 190 keV were compared in 117 patients with lower extremity metal implants (53 female; 62.1 ± 18.0 years). Three implant groups were investigated (total arthroplasty [n = 48], osteosynthetic material [n = 43], and external fixation [n = 26]). Image quality was assessed with regions of interest placed in the most pronounced artifacts and adjacent soft tissue, measuring the respective attenuation. Additionally, artifact extent, bone-metal interface interpretability and overall image quality were independently evaluated by three radiologists. RESULTS: Artifact reduction was superior with increasing keV level of VMI. While T3D was superior to VMI70keV (p ≥ 0.117), artifacts were more severe in T3D than in VMI ≥ 110 keV (all p ≤ 0.036). Image noise was highest for VMI70keV (all p < 0.001) and lowest for VMI110keV with comparable results for VMI110keV - VMI190keV. Subjective image quality regarding artifacts was superior for VMI ≥ 110 keV (all p ≤ 0.042) and comparable for VMI110keV - VMI190keV. Bone-metal interface interpretability was superior for VMI110keV (all p ≤ 0.001), while T3D, VMI150keV and VMI190keV were comparable. Overall image quality was deemed best for VMI110keV and VMI150keV. Interreader reliability was good in all cases (ICC ≥ 0.833). CONCLUSIONS: Tin-filtered UHR-PCCT scans of the lower extremity combined with VMI reconstructions allow for efficient artifact reduction in the vicinity of bone-metal interfaces.

COVID-19-related posterior reversible encephalopathy syndrome: insights from a clinical case.

In the present case report, a 50-year-old female presented with hemiparesis and blurred vision and was subsequently diagnosed with posterior reversible encephalopathy syndrome (PRES) associated with coronavirus disease 2019 (COVID-19). Magnetic resonance imaging revealed cortico-subcortical edema with hyperintensities bilaterally in the frontoparietal and bi-occipital regions. Although PRES is a neurotoxic disorder that typically affects white matter of the brain and often is associated with hypertension, renal failure, and autoimmune disorders, recent studies have suggested that COVID-19 increases the risk of PRES. This case report presents a unique instance of COVID-19-related PRES. Unlike most previously reported cases occurring during the acute phase of severe COVID-19, our patient experienced PRES during the recovery phase with mild initial symptoms, such as fatigue and mild fever. The article discusses the pathophysiology of PRES, the potential mechanisms by which COVID-19 leads to PRES, and the treatment and outcome of the patient.

Shortening Acquisition Time and Improving Image Quality for Pelvic MRI Using Deep Learning Reconstruction for Diffusion-Weighted Imaging at 1.5 T.

RATIONALE AND OBJECTIVES: To determine the impact on acquisition time reduction and image quality of a deep learning (DL) reconstruction for accelerated diffusion-weighted imaging (DWI) of the pelvis at 1.5 T compared to standard DWI. MATERIALS AND METHODS: A total of 55 patients (mean age, 61 ± 13 years; range, 27-89; 20 men, 35 women) were consecutively included in this retrospective, monocentric study between February and November 2022. Inclusion criteria were (1) standard DWI (DWIS) in clinically indicated magnetic resonance imaging (MRI) at 1.5 T and (2) DL-reconstructed DWI (DWIDL). All patients were examined using the institution's standard MRI protocol according to their diagnosis including DWI with two different b-values (0 and 800 s/mm2) and calculation of apparent diffusion coefficient (ADC) maps. Image quality was qualitatively assessed by four radiologists using a visual 5-point Likert scale (5 = best) for the following criteria: overall image quality, noise level, extent of artifacts, sharpness, and diagnostic confidence. The qualitative scores for DWIS and DWIDL were compared with the Wilcoxon signed-rank test. RESULTS: The overall image quality was evaluated to be significantly superior in DWIDL compared to DWIS for b = 0 s/mm2, b = 800 s/mm2, and ADC maps by all readers (P < .05). The extent of noise was evaluated to be significantly less in DWIDL compared to DWIS for b = 0 s/mm2, b = 800 s/mm2, and ADC maps by all readers (P < .001). No significant differences were found regarding artifacts, lesion detectability, sharpness of organs, and diagnostic confidence (P > .05). Acquisition time for DWIS was 2:06 minutes, and simulated acquisition time for DWIDL was 1:12 minutes. CONCLUSION: DL image reconstruction improves image quality, and simulation results suggest that a reduction in acquisition time for diffusion-weighted MRI of the pelvis at 1.5 T is possible.

Novel Deep Learning Denoising Enhances Image Quality and Lowers Radiation Exposure in Interventional Bronchial Artery Embolization Cone Beam CT.

OBJECTIVES: In interventional bronchial artery embolization (BAE), periprocedural cone beam CT (CBCT) improves guiding and localization. However, a trade-off exists between 6-second runs (high radiation dose and motion artifacts, but low noise) and 3-second runs (vice versa). This study aimed to determine the efficacy of an advanced deep learning denoising (DLD) technique in mitigating the trade-offs related to radiation dose and image quality during interventional BAE CBCT. MATERIALS AND METHODS: This study included BMI-matched patients undergoing 6-second and 3-second BAE CBCT scans. The dose-area product values (DAP) were obtained. All datasets were reconstructed using standard weighted filtered back projection (OR) and a novel DLD software. Objective image metrics were derived from place-consistent regions of interest, including CT numbers of the Aorta and lung, noise, and contrast-to-noise ratio. Three blinded radiologists performed subjective assessments regarding image quality, sharpness, contrast, and motion artifacts on all dataset combinations in a forced-choice setup (-1 = inferior, 0 = equal; 1 = superior). The points were averaged per item for a total score. Statistical analysis ensued using a properly corrected mixed-effects model with post hoc pairwise comparisons. RESULTS: Sixty patients were assessed in 30 matched pairs (age 64 ± 15 years; 10 female). The mean DAP for the 6 s and 3 s runs was 2199 ± 185 µGym² and 1227 ± 90 µGym², respectively. Neither low-dose imaging nor the reconstruction method introduced a significant HU shift (p ≥ 0.127). The 3 s-DLD presented the least noise and superior contrast-to-noise ratio (CNR) (p < 0.001). While subjective evaluation revealed no noticeable distinction between 6 s-DLD and 3 s-DLD in terms of quality (p ≥ 0.996), both outperformed the OR variants (p < 0.001). The 3 s datasets exhibited fewer motion artifacts than the 6 s datasets (p < 0.001). CONCLUSIONS: DLD effectively mitigates the trade-off between radiation dose, image noise, and motion artifact burden in regular reconstructed BAE CBCT by enabling diagnostic scans with low radiation exposure and inherently low motion artifact burden at short examination times.

Image Quality and Diagnostic Performance of Accelerated 2D Hip MRI with Deep Learning Reconstruction Based on a Deep Iterative Hierarchical Network.

OBJECTIVES: Hip MRI using standard multiplanar sequences requires long scan times. Accelerating MRI is accompanied by reduced image quality. This study aimed to compare standard two-dimensional (2D) turbo spin echo (TSE) sequences with accelerated 2D TSE sequences with deep learning (DL) reconstruction (TSEDL) for routine clinical hip MRI at 1.5 and 3 T in terms of feasibility, image quality, and diagnostic performance. MATERIAL AND METHODS: In this prospective, monocentric study, TSEDL was implemented clinically and evaluated in 14 prospectively enrolled patients undergoing a clinically indicated hip MRI at 1.5 and 3T between October 2020 and May 2021. Each patient underwent two examinations: For the first exam, we used standard sequences with generalized autocalibrating partial parallel acquisition reconstruction (TSES). For the second exam, we implemented prospectively undersampled TSE sequences with DL reconstruction (TSEDL). Two radiologists assessed the TSEDL and TSES regarding image quality, artifacts, noise, edge sharpness, diagnostic confidence, and delineation of anatomical structures using an ordinal five-point Likert scale (1 = non-diagnostic; 2 = poor; 3 = moderate; 4 = good; 5 = excellent). Both sequences were compared regarding the detection of common pathologies of the hip. Comparative analyses were conducted to assess the differences between TSEDL and TSES. RESULTS: Compared with TSES, TSEDL was rated to be significantly superior in terms of image quality (p ≤ 0.020) with significantly reduced noise (p ≤ 0.001) and significantly improved edge sharpness (p = 0.003). No difference was found between TSES and TSEDL concerning the extent of artifacts, diagnostic confidence, or the delineation of anatomical structures (p > 0.05). Example acquisition time reductions for the TSE sequences of 52% at 3 Tesla and 70% at 1.5 Tesla were achieved. CONCLUSION: TSEDL of the hip is clinically feasible, showing excellent image quality and equivalent diagnostic performance compared with TSES, reducing the acquisition time significantly.

Faster Elbow MRI with Deep Learning Reconstruction-Assessment of Image Quality, Diagnostic Confidence, and Anatomy Visualization Compared to Standard Imaging.

OBJECTIVE: The objective of this study was to evaluate a deep learning (DL) reconstruction for turbo spin echo (TSE) sequences of the elbow regarding image quality and visualization of anatomy. MATERIALS AND METHODS: Between October 2020 and June 2021, seventeen participants (eight patients, nine healthy subjects; mean age: 43 ± 16 (20-70) years, eight men) were prospectively included in this study. Each patient underwent two examinations: standard MRI, including TSE sequences reconstructed with a generalized autocalibrating partial parallel acquisition reconstruction (TSESTD), and prospectively undersampled TSE sequences reconstructed with a DL reconstruction (TSEDL). Two radiologists evaluated the images concerning image quality, noise, edge sharpness, artifacts, diagnostic confidence, and delineation of anatomical structures using a 5-point Likert scale, and rated the images concerning the detection of common pathologies. RESULTS: Image quality was significantly improved in TSEDL (mean 4.35, IQR 4-5) compared to TSESTD (mean 3.76, IQR 3-4, p = 0.008). Moreover, TSEDL showed decreased noise (mean 4.29, IQR 3.5-5) compared to TSESTD (mean 3.35, IQR 3-4, p = 0.004). Ratings for delineation of anatomical structures, artifacts, edge sharpness, and diagnostic confidence did not differ significantly between TSEDL and TSESTD (p > 0.05). Inter-reader agreement was substantial to almost perfect (κ = 0.628-0.904). No difference was found concerning the detection of pathologies between the readers and between TSEDL and TSESTD. Using DL, the acquisition time could be reduced by more than 35% compared to TSESTD. CONCLUSION: TSEDL provided improved image quality and decreased noise while receiving equal ratings for edge sharpness, artifacts, delineation of anatomical structures, diagnostic confidence, and detection of pathologies compared to TSESTD. Providing more than a 35% reduction of acquisition time, TSEDL may be clinically relevant for elbow imaging due to increased patient comfort and higher patient throughput.