[Headache in elderly patients].

Epidemiological studies reveal that the prevalence of primary forms of headache, in particular migraine and headache of tension, decreases with age. At the same time, there is the increase in the percentage of secondary forms of headache associated with brain tumors, temporal arteritis, subdural hematoma. Thus, elderly patients with newly developed or modified headache should be fully examined including neuroimaging. The choice of treatment should take into account concomitant diseases, in particular liver and kidney insufficiency, and possible interactions with other drugs.

[Mechanisms of lability of neurological symptoms in multiple sclerosis]. / Mekhanizmy labil'nosti nevrologicheskikh simptomov pri rasseiannom skleroze.

Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body temperature may cause changes in impulse conduction in demyelinated fibres, which was proved by studies of evoked potentials and stabilometric studies. These disturbances may be associated with disorder of ions channels function. The role of other factors (metabolic and immunological disturbances, levels of cytokines and neurotransmitters) in temporary block of nerve conduction in MS is discussed. Further studies of the mechanisms of the lability of neurological sings in MS may lead to elaboration of new approaches to MS treatment.